Difference between revisions of "Bile duct adenoma"

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Line 28: Line 28:
*CK7 +ve.
*CK7 +ve.
*HepPar-1 -ve.
*HepPar-1 -ve.
*HMGA1 -ve/+ve.
*Ki-67 low.
*HMGA2 -ve/+ve.
 
Note:
*HMGA1 & HMGA2 together may be useful for differentiating from adenocarcioma.<ref name=pmid23530587>{{Cite journal  | last1 = Zakharov | first1 = V. | last2 = Ren | first2 = B. | last3 = Ryan | first3 = C. | last4 = Cao | first4 = W. | title = Diagnostic value of HMGAs, p53 and β-catenin in discriminating adenocarcinoma from adenoma or reactive atypia in ampulla and common bile duct biopsies. | journal = Histopathology | volume = 62 | issue = 5 | pages = 778-87 | month = Apr | year = 2013 | doi = 10.1111/his.12084 | PMID = 23530587 }}
</ref>


==See also==
==See also==

Revision as of 01:22, 7 March 2014

Bile duct adenoma is a benign liver lesion characterized composed of bile duct epithelium.

It is also known as a benign bile duct proliferation.[1]

General

  • Benign.
  • Important as it can be misdiagnosed as cancer.

Microscopic

Features:

  • Disordered bile ducts within in a fibrotic stroma.
    • No (yellow) bile within, as these lesions do not have a connection to the biliary tree.
    • +/-Lymphocytic cuff.

Negatives:

  • No mitotic activity.
  • No necrosis.

DDx:

Images

IHC

  • CK7 +ve.
  • HepPar-1 -ve.
  • Ki-67 low.

See also

References

  1. ↑ Johannesen, EJ.; Wu, Z.; Holly, JS. (2014). "Bile duct adenoma with oncocytic features.". Case Rep Pathol 2014: 282010. doi:10.1155/2014/282010. PMID 24592348.
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