Difference between revisions of "Angiomyofibroblastoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
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| Micro = hypercellular zones and hypocellular edematous zones, small blood vessels (~20 micrometers) - no large blood vessels, [[myxoid stroma]], small stellate cell/spindle cells without significant nuclear atypia | |||
| Subtypes = | |||
| LMDDx = [[aggressive angiomyxoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = well-circumscribed | |||
| Grossing = | |||
| Site = female pelvis ([[vulva]]), case reports of similar lesion in males | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = slow growing, usu. not painful | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = [[Bartholin cyst]], [[aggressive angiomyxoma]] | |||
| Tx = | |||
}} | |||
'''Angiomyofibroblastoma''' is rare uncommon [[soft tissue lesion]] of the [[vulva]]. | '''Angiomyofibroblastoma''' is rare uncommon [[soft tissue lesion]] of the [[vulva]]. | ||
Revision as of 00:09, 17 February 2014
| Angiomyofibroblastoma | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | hypercellular zones and hypocellular edematous zones, small blood vessels (~20 micrometers) - no large blood vessels, myxoid stroma, small stellate cell/spindle cells without significant nuclear atypia |
| LM DDx | aggressive angiomyxoma |
| Gross | well-circumscribed |
| Site | female pelvis (vulva), case reports of similar lesion in males |
|
| |
| Clinical history | slow growing, usu. not painful |
| Prevalence | very rare |
| Clin. DDx | Bartholin cyst, aggressive angiomyxoma |
Angiomyofibroblastoma is rare uncommon soft tissue lesion of the vulva.
General
Clinical:[3]
- Slow growing.
- Uncommonly recur.
- Usually painless.
Clinical DDx:
Gross
- Vulvar lesion.
- Well-circumscribed.[3]
Microscopic
Features:[4]
- Hypercellular zones and hypocellular edematous zones.
- Small blood vessels (~20 micrometers) - no large blood vessels - key feature.
- Myxoid stroma - key feature.
- Small stellate cell/spindle cells without significant nuclear atypia.
DDx:
- Aggressive angiomyxoma - less cellular, large blood vessels.
Images
www:
- Angiomyofibroblastoma (webpathology.com)
- Angiomyofibroblastoma - high mag. (webpathology.com).
- Angiomyofibroblastoma-like tumour of scrotum (nih.gov).[1]
IHC
- SMA +ve.
- S-100 -ve.
- Actin -ve.
- CD34 -ve.
See also
References
- ↑ 1.0 1.1 Ding, G.; Yu, Y.; Jin, M.; Xu, J.; Zhang, Z. (Feb 2014). "Angiomyofibroblastoma-like tumor of the scrotum: A case report and literature review.". Oncol Lett 7 (2): 435-438. doi:10.3892/ol.2013.1741. PMID 24396463.
- ↑ Butt, Z.; Slatnik, J.; Estey, EP. (Dec 2013). "Robotic assisted laparoscopic excision of a pelvic angiomyofibroblastoma-like tumor.". Can J Urol 20 (6): 7067-9. PMID 24331351.
- ↑ 3.0 3.1 Seo, JW.; Lee, KA.; Yoon, NR.; Lee, JW.; Kim, BG.; Bae, DS. (Sep 2013). "Angiomyofibroblastoma of the vulva.". Obstet Gynecol Sci 56 (5): 349-51. doi:10.5468/ogs.2013.56.5.349. PMID 24328028.
- ↑ Fletcher, CD.; Tsang, WY.; Fisher, C.; Lee, KC.; Chan, JK. (Apr 1992). "Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma.". Am J Surg Pathol 16 (4): 373-82. PMID 1314521.