Difference between revisions of "Lung carcinoma with ALK rearrangement"
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===Images=== | ===Images=== | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400179/figure/f1-cln_67p845/ Lung carcinoma with ALK rearrangement (nih.gov)].<ref name=pmid22892933>{{Cite journal | last1 = Lopes | first1 = LF. | last2 = Bacchi | first2 = CE. | title = Anaplastic lymphoma kinase gene rearrangement in non-small-cell lung cancer in a Brazilian population. | journal = Clinics (Sao Paulo) | volume = 67 | issue = 7 | pages = 845-7 | month = Jul | year = 2012 | doi = | PMID = 22892933 }}</ref> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400179/figure/f1-cln_67p845/ Lung carcinoma with ALK rearrangement (nih.gov)].<ref name=pmid22892933>{{Cite journal | last1 = Lopes | first1 = LF. | last2 = Bacchi | first2 = CE. | title = Anaplastic lymphoma kinase gene rearrangement in non-small-cell lung cancer in a Brazilian population. | journal = Clinics (Sao Paulo) | volume = 67 | issue = 7 | pages = 845-7 | month = Jul | year = 2012 | doi = | PMID = 22892933 }}</ref> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731315/figure/pone-0069794-g002/ Lung carcinoma with ALK rearrangment (nih.gov)] | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731315/figure/pone-0069794-g002/ Lung carcinoma with ALK rearrangment (nih.gov)]<ref>{{Cite journal | last1 = Takamochi | first1 = K. | last2 = Takeuchi | first2 = K. | last3 = Hayashi | first3 = T. | last4 = Oh | first4 = S. | last5 = Suzuki | first5 = K. | title = A rational diagnostic algorithm for the identification of ALK rearrangement in lung cancer: a comprehensive study of surgically treated Japanese patients. | journal = PLoS One | volume = 8 | issue = 8 | pages = e69794 | month = | year = 2013 | doi = 10.1371/journal.pone.0069794 | PMID = 23936355 }}</ref> - [http://www.plosone.org/article/info:doi/10.1371/journal.pone.0069794.g002/largerimage high resolution (plosone.org)]. | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid21753699/> | Features:<ref name=pmid21753699/> | ||
Revision as of 11:47, 26 December 2013
Lung carcinoma with ALK rearrangement is subset of lung adenocarcinoma.
General
Microscopic
Features:[1]
- Adenocarcinoma - at least focally.
- Solid signet-ring cell pattern - common.
- Mucinous cribriform pattern - common.
DDx:
Images
- Lung carcinoma with ALK rearrangement (nih.gov).[3]
- Lung carcinoma with ALK rearrangment (nih.gov)[4] - high resolution (plosone.org).
IHC
Features:[1]
- p63 +ve.
- TTF-1 +ve.
Molecular
- EML4-ALK fusion -- inv(2)(p21p23).[5]
See also
References
- ↑ 1.0 1.1 1.2 Yoshida, A.; Tsuta, K.; Nakamura, H.; Kohno, T.; Takahashi, F.; Asamura, H.; Sekine, I.; Fukayama, M. et al. (Aug 2011). "Comprehensive histologic analysis of ALK-rearranged lung carcinomas.". Am J Surg Pathol 35 (8): 1226-34. doi:10.1097/PAS.0b013e3182233e06. PMID 21753699.
- ↑ Crystal, AS.; Shaw, AT. (Mar 2011). "New targets in advanced NSCLC: EML4-ALK.". Clin Adv Hematol Oncol 9 (3): 207-14. PMID 21475126.
- ↑ Lopes, LF.; Bacchi, CE. (Jul 2012). "Anaplastic lymphoma kinase gene rearrangement in non-small-cell lung cancer in a Brazilian population.". Clinics (Sao Paulo) 67 (7): 845-7. PMID 22892933.
- ↑ Takamochi, K.; Takeuchi, K.; Hayashi, T.; Oh, S.; Suzuki, K. (2013). "A rational diagnostic algorithm for the identification of ALK rearrangement in lung cancer: a comprehensive study of surgically treated Japanese patients.". PLoS One 8 (8): e69794. doi:10.1371/journal.pone.0069794. PMID 23936355.
- ↑ Li, Y.; Ye, X.; Liu, J.; Zha, J.; Pei, L. (Jan 2011). "Evaluation of EML4-ALK fusion proteins in non-small cell lung cancer using small molecule inhibitors.". Neoplasia 13 (1): 1-11. PMID 21245935.