Difference between revisions of "Intestinal metaplasia of the gallbladder"
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DDx: | DDx: | ||
*[[Gallbladder adenocarcinoma]]. | *[[Gallbladder adenocarcinoma]]. | ||
*[[Gallbladder adenoma]] (gallbladder dysplasia). | |||
===Images=== | ===Images=== | ||
Revision as of 02:50, 17 December 2013
| Intestinal metaplasia of the gallbladder | |
|---|---|
| Diagnosis in short | |
 Gallbladder with intestinal metaplasia. H&E stain. | |
|
| |
| LM | gallbladder mucosa with goblet cells +/-Paneth cells |
| LM DDx | gallbladder dysplasia, gallbladder carcinoma |
| Stains | Alcian blue stain +ve |
| Site | gallbladder |
|
| |
| Associated Dx | chronic cholecystitis |
| Prognosis | benign, increased risk of carcinoma |
Intestinal metaplasia of the gallbladder is a pathology of the gallbladder associated with an increased risk of gallbladder carcinoma.
It is also known as gallbladder intestinal metaplasia.
General
- Associated with chronic cholecystitis.[1]
- Not associated with acute cholecystitis.
Significance:
- Increased risk of carcinoma.[2]
Gross
- No specific changes.
Note:
- Usually seen in the context of chronic cholecystitis if isolated.
Microscopic
Features:[3]
- Goblet cells - key feature.
- +/-Paneth cells.[4]
Note:
- Often accompanied by antral type metplasia.
- Gastric antral-type epithelium - may form glands.
DDx:
- Gallbladder adenocarcinoma.
- Gallbladder adenoma (gallbladder dysplasia).
Images
GB with IM - low mag.
GB with IM - intermed. mag.
GB with IM - high mag.
www:
Stains
- Alcian blue/PAS +ve.
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GALLBLADDER, CHOLECYSTECTOMY: - INTESTINAL METAPLASIA OF THE GALLBLADDER, FOCAL. - CHRONIC CHOLECYSTITIS. - CHOLELITHIASIS. - NEGATIVE FOR DYSPLASIA.
See also
References
- ↑ Sai, K.; Kajiwara, H. (2001). "An immunohistochemical study of metaplastic endocrine cells in human gallbladder cancer.". J Hepatobiliary Pancreat Surg 8 (5): 453-60. PMID 11702256.
- ↑ Duarte, I.; Llanos, O.; Domke, H.; Harz, C.; Valdivieso, V. (Sep 1993). "Metaplasia and precursor lesions of gallbladder carcinoma. Frequency, distribution, and probability of detection in routine histologic samples.". Cancer 72 (6): 1878-84. PMID 8364865.
- ↑ Albores-Saavedra, J.; Nadji, M.; Henson, DE.; Ziegels-Weissman, J.; Mones, JM. (Jun 1986). "Intestinal metaplasia of the gallbladder: a morphologic and immunocytochemical study.". Hum Pathol 17 (6): 614-20. PMID 2872152.
- ↑ Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Oberman, Harold A; Reuter, Victor E (2004). Sternberg's Diagnostic Surgical Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 1789. ISBN 978-0781740517.
- ↑ Mukhopadhyay, S.; Landas, SK. (Mar 2005). "Putative precursors of gallbladder dysplasia: a review of 400 routinely resected specimens.". Arch Pathol Lab Med 129 (3): 386-90. doi:10.1043/1543-2165(2005)129386:PPOGDA2.0.CO;2. PMID 15737036.