Difference between revisions of "CNS cytopathology"
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{{familytree | C01 | | | | C02 | | C03 | | | | C04 | |C01=Glial|C02=Non-glial|C03=Infectious|C04=Non-infectious }} | {{familytree | C01 | | | | C02 | | C03 | | | | C04 | |C01=Glial|C02=Non-glial|C03=Infectious|C04=Non-infectious }} | ||
{{familytree/end}} | {{familytree/end}} | ||
{| class="wikitable" | |||
| | |||
| Glial | |||
| Non-glial | |||
|- | |||
| Stranding <br>(cytoplasmic) | |||
| thin - cannot be seen at low <br>power (2.5x obj.), true cytoplasmic <br>processes | |||
| thick - can be seen at low <br>power (2.5x obj.), artifact of smearing | |||
|- | |||
| Edge of cluster | |||
| smooth/non-distinct | |||
| sharp | |||
|} | |||
Glial vs non-glial: | Glial vs non-glial: | ||
*Glial has | *Glial has ctyoplasmic processes/cytoplasmic strands (stringy processes) ~ 1 micrometer thick. | ||
**They cannot be seen well at low power. | |||
**Cotton candy-like appearance. | |||
**Images: | **Images: | ||
*** [http://www.msdlatinamerica.com/ebooks/DiagnosticNeuropathologySmears/files/cf76aad0d9dab70c99b93186ca8b3ad4.gif Stringy processes - glial tumour (msdlatinamerica.com)].<ref name=latinam>URL: [http://www.msdlatinamerica.com/ebooks/DiagnosticNeuropathologySmears/sid117213.html http://www.msdlatinamerica.com/ebooks/DiagnosticNeuropathologySmears/sid117213.html]. Accessed on: 2 November 2010.</ref> | *** [http://www.msdlatinamerica.com/ebooks/DiagnosticNeuropathologySmears/files/cf76aad0d9dab70c99b93186ca8b3ad4.gif Stringy processes - glial tumour (msdlatinamerica.com)].<ref name=latinam>URL: [http://www.msdlatinamerica.com/ebooks/DiagnosticNeuropathologySmears/sid117213.html http://www.msdlatinamerica.com/ebooks/DiagnosticNeuropathologySmears/sid117213.html]. Accessed on: 2 November 2010.</ref> | ||
Revision as of 13:28, 5 November 2010
CNS cytopathology is a subset of neuropathology and cytopathology.
An introduction to cytopathology is in the cytopathology article. Cerebrospinal (CSF) specimens are dealt with in a separate article called CSF cytopathology.
Basic approach
| CNS cytology | |||||||||||||||||||||||||||||||||||||||||
| Tumour | Non-tumour | ||||||||||||||||||||||||||||||||||||||||
| Glial | Non-glial | Infectious | Non-infectious | ||||||||||||||||||||||||||||||||||||||
| Glial | Non-glial | |
| Stranding (cytoplasmic) |
thin - cannot be seen at low power (2.5x obj.), true cytoplasmic processes |
thick - can be seen at low power (2.5x obj.), artifact of smearing |
| Edge of cluster | smooth/non-distinct | sharp |
Glial vs non-glial:
- Glial has ctyoplasmic processes/cytoplasmic strands (stringy processes) ~ 1 micrometer thick.
- They cannot be seen well at low power.
- Cotton candy-like appearance.
- Images:
Notes:
- Crush artifact (in smear preparation) can mimic glial processes.
- Crush artifact vs. real glial processes:
- No glial processes run perpendicular to the direction of smear.
- Glial processes may branch.
- Crushed/elongated nuclei are present in artifactual processes.
- Crush artifact vs. real glial processes:
Metastatic carcinoma
- Squamous cell carcinoma (ouhsc.edu).[2]
- Adenocarcioma (ouhsc.edu).
- Small cell carcinoma (ouhsc.edu).
Things that don't smear well
Cohesive tumours:
Things that smear well
Dyscohesive tumours:[4]
- Lymphoma.
- Pituitary adenoma.
- Oligodendroglioma.
See also
References
- ↑ 1.0 1.1 URL: http://www.msdlatinamerica.com/ebooks/DiagnosticNeuropathologySmears/sid117213.html. Accessed on: 2 November 2010.
- ↑ URL: http://moon.ouhsc.edu/kfung/JTY1/NeuroTest/Q92-Ans.htm. Accessed on: 3 November 2010.
- ↑ 3.0 3.1 Ironside JW (August 1994). "Update on central nervous system cytopathology. II. Brain smear technique". J. Clin. Pathol. 47 (8): 683–8. PMC 502135. PMID 7962615. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC502135/.
- ↑ 4.0 4.1 4.2 4.3 Weedman Molavi, Diana (2008). The Practice of Surgical Pathology: A Beginner's Guide to the Diagnostic Process (1st ed.). Springer. pp. 252. ISBN 978-0387744858.