Difference between revisions of "Vascular malformations"
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**"Large" = ~ 0.5 mm (0.25-1.0 mm). | **"Large" = ~ 0.5 mm (0.25-1.0 mm). | ||
***0.25 mm = ~ 31 RBC diameters across. | ***0.25 mm = ~ 31 RBC diameters across. | ||
Notes: | Notes: | ||
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*Arteries have a well-defined internal elastic lamina and an external elastic lamina (best seen on elastic trichrome). | *Arteries have a well-defined internal elastic lamina and an external elastic lamina (best seen on elastic trichrome). | ||
**[[Vein]]s do not have an external elastic lamina and have a poorly developed/thin internal elastic lamina. | **[[Vein]]s do not have an external elastic lamina and have a poorly developed/thin internal elastic lamina. | ||
====Images==== | |||
<gallery> | |||
Image:Arteriovenous_malformation_-_brain_-_low_mag.jpg | Cerebral AVM. (WC) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case123.html AVM - several images (upmc.edu)]. | |||
===Sign out=== | ===Sign out=== | ||
Revision as of 08:07, 4 September 2013
Vascular malformations come in different flavours.
Types:[1]
- Arteriovenous malformation.
- Most important clinically - highest risk of bleeding.
- Varix.
- One large (dilated) vein.
- Venous angioma.
- Many small veins.
- Caverous malformation.
- Vessels are back-to-back (no intervening parenchyma).
Also see: Sturge-Weber syndrome.
Arteriovenous malformation
- Abbreviated AVM.
General
- High risk for bleeding vis-a-vis other vascular malformations.
- May be seen in the context of hereditary hemorrhagic telangiectasia.[2]
Gross
Features:[1]
- Classically wedge-shaped - with base toward superficial aspect and apex toward deep aspect (like pulmonary infarcts).
- Usually middle cerebral artery distribution.
Image:
Microscopic
Features:
- Large vessels with eccentric wall thickening.
- "Large" = ~ 0.5 mm (0.25-1.0 mm).
- 0.25 mm = ~ 31 RBC diameters across.
- "Large" = ~ 0.5 mm (0.25-1.0 mm).
Notes:
- There is usually one feeding artery.
- The artery is often not seen.
- Arteries have a well-defined internal elastic lamina and an external elastic lamina (best seen on elastic trichrome).
- Veins do not have an external elastic lamina and have a poorly developed/thin internal elastic lamina.
Images
Cerebral AVM. (WC)
www:
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ANUS, BIOPSY: - ARTERIOVENOUS MALFORMATION (PROMINENT SUPERFICIAL DERMAL ARTERIES AND VEINS). - SKIN WITH PARAKERATOSIS. - NEGATIVE FOR MELANOCYTIC LESION. - NEGATIVE FOR MALIGNANCY.
ANUS, BIOPSY: - SKIN WITH PARAKERATOSIS. - PROMINENT SUPERFICIAL DERMAL ARTERIES AND VEINS -- COMPATIBLE WITH ARTERIOVENOUS MALFORMATION. - NEGATIVE FOR MELANOCYTIC LESION. - NEGATIVE FOR MALIGNANCY.
Cavernous angioma
General
- Usually diagnosed by radiology.
Microscopic
Features:
- Vessels back-to-back/little intervening parenchyma.
- Muscle is absent in the vessel walls - key feature.[3]
Cherry angioma
General
- Benign.
- Common in the elderly.
Clincal:
- Red spot.
- Polypoid.
Gross
- Red spot - well demarcated.
Image:
Microscopic
Features:[5]
- Superficial polypoid lesion that is well-circumscribed.
- Abundant capillaries - key feature.
DDx:
- Venous lake - single vessel.[6]
- Hemangioma.
Images:
See also
References
- ↑ 1.0 1.1 Prayson RA, Kleinschmidt-DeMasters BK (November 2006). "An algorithmic approach to the brain biopsy--part II". Arch. Pathol. Lab. Med. 130 (11): 1639–48. PMID 17076525.
- ↑ Marchuk, DA.; Srinivasan, S.; Squire, TL.; Zawistowski, JS. (Apr 2003). "Vascular morphogenesis: tales of two syndromes.". Hum Mol Genet 12 Spec No 1: R97-112. PMID 12668602.
- ↑ MUN. 23 November 2010.
- ↑ 4.0 4.1 URL:: http://missinglink.ucsf.edu/lm/DermatologyGlossary/cherry_angioma.html. Accessed on: 13 August 2012.
- ↑ Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 546. ISBN 978-0443066542.
- ↑ Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 551. ISBN 978-0443066542.