Difference between revisions of "Osteoblastoma"
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| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = | | Site = [[bone]] - vertebral column typically, other bones | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = usu. 15-20 years old, males > females | | Clinicalhx = usu. 15-20 years old, males > females | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = usu. pain | ||
| Prevalence = | | Prevalence = | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = > 1.5 cm (smaller lesions [[osteoid osteoma]]) | | Rads = > 1.5 cm (smaller lesions [[osteoid osteoma]]), often well-circumscribed, cortical expansion, +/-cortical destruction | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = benign, may be locally destructive | ||
| Other = | | Other = | ||
| ClinDDx = [[osteosarcoma]] | | ClinDDx = [[osteosarcoma]] | ||
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==General== | ==General== | ||
*Benign bone tumour. | *Benign bone tumour - that can be locally destructive and occasionally recurs.<ref name=pmid8119712/> | ||
*Uncommon.<ref name=pmid23362588>{{Cite journal | last1 = Khan | first1 = IS. | last2 = Thakur | first2 = JD. | last3 = Chittiboina | first3 = P. | last4 = Nanda | first4 = A. | title = Large sacral osteoblastoma: a case report and review of multi-disciplinary management strategies. | journal = J La State Med Soc | volume = 164 | issue = 5 | pages = 251-5 | month = | year = | doi = | PMID = 23362588 }}</ref> | *Uncommon.<ref name=pmid23362588>{{Cite journal | last1 = Khan | first1 = IS. | last2 = Thakur | first2 = JD. | last3 = Chittiboina | first3 = P. | last4 = Nanda | first4 = A. | title = Large sacral osteoblastoma: a case report and review of multi-disciplinary management strategies. | journal = J La State Med Soc | volume = 164 | issue = 5 | pages = 251-5 | month = | year = | doi = | PMID = 23362588 }}</ref> | ||
*Typically age 15-20 and male (male:female = ~2:1).<ref name=pmid20345366>{{Cite journal | last1 = Villalobos | first1 = CE. | last2 = Rybak | first2 = LD. | last3 = Steiner | first3 = GC. | last4 = Wittig | first4 = JC. | title = Osteoblastoma of the sternum--case report and review of the literature. | journal = Bull NYU Hosp Jt Dis | volume = 68 | issue = 1 | pages = 55-9 | month = | year = 2010 | doi = | PMID = 20345366 }}</ref> | *Typically age 15-20 and male (male:female = ~2:1).<ref name=pmid20345366>{{Cite journal | last1 = Villalobos | first1 = CE. | last2 = Rybak | first2 = LD. | last3 = Steiner | first3 = GC. | last4 = Wittig | first4 = JC. | title = Osteoblastoma of the sternum--case report and review of the literature. | journal = Bull NYU Hosp Jt Dis | volume = 68 | issue = 1 | pages = 55-9 | month = | year = 2010 | doi = | PMID = 20345366 }}</ref> | ||
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Notes: | Notes: | ||
*Histomorphologically near identical/indistinguishable from ''[[osteoid osteoma]]''.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref> | *Histomorphologically near identical/indistinguishable from ''[[osteoid osteoma]]''.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref> | ||
DDx: | |||
*[[Osteosarcoma]].<ref name=pmid8119712/> | |||
===Images=== | ===Images=== | ||
Revision as of 21:36, 26 August 2013
| Osteoblastoma | |
|---|---|
| Diagnosis in short | |
 Osteoblastoma. H&E stain. | |
|
| |
| LM | anastomosing bony trabeculae with variable mineralization, osteoblast rimming, no nuclear atypia of osteocytes |
| LM DDx | osteoid osteoma, osteosarcoma |
| Site | bone - vertebral column typically, other bones |
|
| |
| Clinical history | usu. 15-20 years old, males > females |
| Symptoms | usu. pain |
| Radiology | > 1.5 cm (smaller lesions osteoid osteoma), often well-circumscribed, cortical expansion, +/-cortical destruction |
| Prognosis | benign, may be locally destructive |
| Clin. DDx | osteosarcoma |
Osteoblastoma is benign primary bone tumour.
General
- Benign bone tumour - that can be locally destructive and occasionally recurs.[1]
- Uncommon.[2]
- Typically age 15-20 and male (male:female = ~2:1).[3]
- Treatment: resection.[3]
Gross
- Bone.
- Vertebral column and sacrum - most common in one large series.[1]
- Must be greater 1.5 cm by definition.[4]
Microscopic
Features:[5]
- Anastomosing bony trabeculae with:
- Osteoblasts rimming.
- Cells line-up at edge of bone.
- Osteoblasts rimming.
Notes:
- Histomorphologically near identical/indistinguishable from osteoid osteoma.[4]
DDx:
Images
Osteoblastoma - high mag. (WC)
Osteoblastoma - low mag. (WC)
Sign out
BONE, LEFT FEMUR, EXCISION: - OSTEOBLASTOMA.
See also
References
- ↑ 1.0 1.1 1.2 Lucas, DR.; Unni, KK.; McLeod, RA.; O'Connor, MI.; Sim, FH. (Feb 1994). "Osteoblastoma: clinicopathologic study of 306 cases.". Hum Pathol 25 (2): 117-34. PMID 8119712.
- ↑ Khan, IS.; Thakur, JD.; Chittiboina, P.; Nanda, A.. "Large sacral osteoblastoma: a case report and review of multi-disciplinary management strategies.". J La State Med Soc 164 (5): 251-5. PMID 23362588.
- ↑ 3.0 3.1 Villalobos, CE.; Rybak, LD.; Steiner, GC.; Wittig, JC. (2010). "Osteoblastoma of the sternum--case report and review of the literature.". Bull NYU Hosp Jt Dis 68 (1): 55-9. PMID 20345366.
- ↑ 4.0 4.1 Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Oberman, Harold A; Reuter, Victor E (2004). Sternberg's Diagnostic Surgical Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 286. ISBN 978-0781740517.
- ↑ Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Oberman, Harold A; Reuter, Victor E (2004). Sternberg's Diagnostic Surgical Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 285. ISBN 978-0781740517.