Difference between revisions of "Gaucher disease"

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'''Gaucher disease''' a [[lysosomal storage diseases|lysosomal storage disease]].  It is a rare thingy that may be seen in people that marry their cousins.  
'''Gaucher disease''' is the most common [[lysosomal storage diseases|lysosomal storage disease]].<ref name=pmid18466035>{{Cite journal | last1 = Chen | first1 = M. | last2 = Wang | first2 = J. | title = Gaucher disease: review of the literature. | journal = Arch Pathol Lab Med | volume = 132 | issue = 5 | pages = 851-3 | month = May | year = 2008 | doi = 10.1043/1543-2165(2008)132[851:GDROTL]2.0.CO;2 | PMID = 18466035 }}</ref> 
 
Despite being the most common in its grouping, it is still quite rare. Like most [[storage disorders]], it is inherited autosomal recessive; thus, it is seen more commonly in families where people are marry their cousins.  


==General==
==General==

Revision as of 02:21, 29 November 2013

Gaucher disease
Diagnosis in short

Gaucher disease. H&E stain.
LM crumpled tissue paper macrophages
Subtypes type I, type II, type III
Site bone, other
Associated Dx fracture of bone
Blood work pancytopenia
Prognosis dependent on subtype

Gaucher disease is the most common lysosomal storage disease.[1]

Despite being the most common in its grouping, it is still quite rare. Like most storage disorders, it is inherited autosomal recessive; thus, it is seen more commonly in families where people are marry their cousins.

General

Pathology:

  • Accumulation of glucocerebroside in monocytes/macrophages due to deficiency of glucocerebrosidase.[2]
  • Defect in acid beta-glucosidase gene (GBA gene).[3][4][5]

Subtypes

  • There are several types - all are autosomal recessive.[2]

Types:[6]

  • Type I: 99% of cases; no CNS involvement - survive to adulthood.
  • Type II: infantile onset - CNS degeneration + death at young age.
  • Type III: mixed of type I & type II.

Clinical

  • Pancytopenia - due to marrow replacement.
  • Hepatosplenomegaly (type I).

Microscopic

Features:[7][6]

  • Mononuclear phagocytes with abundant eosinophilic cytoplasm with subtle irregular lines (~0.5 micrometers in width).
    • Known as "crumpled tissue paper cells" / "crumpled tissue paper cytoplasm."[8]

Notes:

  • Crumpled tissue paper: crumpled tissue paper - image (123rf.com).
  • The textbook case may look crumpled... along with some mind altering drugs.
    • The typical case is:
      • Abundant macrophages with cytoplasm filled by very small (clear) vacuoles (~0.2-0.4 micrometres).

Images

  • Gaucher disease - intermed. mag. (WC)

  • Gaucher disease - high mag. (WC)

  • Gaucher disease - with fine vesicular cytoplasm - very high mag. (WC)

www:

Stains

  • Material in "crumpled tissue paper cells": PAS +ve.[6]

See also

References

  1. ↑ Chen, M.; Wang, J. (May 2008). "Gaucher disease: review of the literature.". Arch Pathol Lab Med 132 (5): 851-3. doi:10.1043/1543-2165(2008)132[851:GDROTL]2.0.CO;2. PMID 18466035.
  2. ↑ 2.0 2.1 URL: http://emedicine.medscape.com/article/944157-overview. Accessed on: 3 December 2010.
  3. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 230800
  4. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 230900
  5. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 231000
  6. ↑ 6.0 6.1 6.2 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 95. ISBN 978-1416054542.
  7. ↑ 7.0 7.1 URL: http://www.webpathology.com/image.asp?case=377&n=3. Accessed on: 30 November 2010.
  8. ↑ URL: http://pathcuric1.swmed.edu/pathdemo/gen1/gen130.htm. Accessed on: 28 May 2011.
  9. ↑ URL: http://www.neuropathologyweb.org/chapter10/chapter10bLSDs.html. Accessed on: 30 November 2010.
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