Difference between revisions of "Glioblastoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Glioblastoma_-_high_mag.jpg | |||
| Width = | |||
| Caption = Glioblastoma. [[H&E stain]]. | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = [[anaplastic astrocytoma]] | |||
| Stains = | |||
| IHC = GFAP +ve, IDH-1 -ve/+ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = brain, spinal cord | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = intraaxial | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Glioblastoma''' a very common malignant [[brain tumour]] in adults. | '''Glioblastoma''' a very common malignant [[brain tumour]] in adults. | ||
Revision as of 23:26, 23 July 2013
| Glioblastoma | |
|---|---|
| Diagnosis in short | |
 Glioblastoma. H&E stain. | |
| LM DDx | anaplastic astrocytoma |
| IHC | GFAP +ve, IDH-1 -ve/+ve |
| Site | brain, spinal cord |
|
| |
| Radiology | intraaxial |
Glioblastoma a very common malignant brain tumour in adults.
It was previously known as glioblastoma multiforme, abbreviated GBM.
General
- Median survival is measured in months.[1]
- Only about 5% can expect to survive more than three years.[2]
Microscopic
Features:
- Astrocytic tumour with:
- Nuclear atypia.
- Necrosis.
- Endothelial proliferation (AKA microvascular proliferation).
- +/-"Pseudopalisading necrosis" - tumour cells lined-up like a picket fence around necrotic areas.
Images
- www:
Extreme nuclear enlargement in a GBM - very high mag. (WC)
GBM juxtaposed with near normal white matter - high mag. (WC)
IHC
- GFAP +ve (cytoplasm).
- IDH-1 -ve.
- +ve if developed from lower grade astrocytoma. (???)
See also
References
- ↑ Jubelirer, SJ.. "A review of the treatment and survival rates of 138 patients with glioblastoma multiforme.". W V Med J 92 (4): 186-90. PMID 8772403.
- ↑ Krex, D.; Klink, B.; Hartmann, C.; von Deimling, A.; Pietsch, T.; Simon, M.; Sabel, M.; Steinbach, JP. et al. (Oct 2007). "Long-term survival with glioblastoma multiforme.". Brain 130 (Pt 10): 2596-606. doi:10.1093/brain/awm204. PMID 17785346.