Difference between revisions of "Tissue loss"
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In pathology, '''tissue loss''' is when less tissue | In pathology, '''tissue loss''' is when a section at microscopy appears to represent less tissue then one could reasonably expect from the [[gross pathology|gross]]. It is relatively common in small biopsies. | ||
It is estimated that approximately 27% of cases have a mismatch between the number of pieces seen at [[gross pathology|gross]] and microscopy.<ref name=pmid22129184>{{Cite journal | last1 = Owens | first1 = SR. | last2 = Wiehagen | first2 = L. | last3 = Simmons | first3 = C. | last4 = Sikorova | first4 = A. | last5 = Stewart | first5 = W. | last6 = Kelly | first6 = S. | last7 = Nestler | first7 = R. | last8 = Yousem | first8 = SA. | title = Numerical fidelity of endoscopic biopsy fragments in the processing sequence of a university surgical pathology laboratory. | journal = Arch Pathol Lab Med | volume = 135 | issue = 12 | pages = 1561-4 | month = Dec | year = 2011 | doi = 10.5858/arpa.2011-0020-OA | PMID = 22129184 }}</ref> A tissue gain is seen in approximately 25% of cases and a tissue loss is seen in approximately 7% of cases.<ref name=pmid22129184/> | It is estimated that approximately 27% of cases have a mismatch between the number of pieces seen at [[gross pathology|gross]] and microscopy.<ref name=pmid22129184>{{Cite journal | last1 = Owens | first1 = SR. | last2 = Wiehagen | first2 = L. | last3 = Simmons | first3 = C. | last4 = Sikorova | first4 = A. | last5 = Stewart | first5 = W. | last6 = Kelly | first6 = S. | last7 = Nestler | first7 = R. | last8 = Yousem | first8 = SA. | title = Numerical fidelity of endoscopic biopsy fragments in the processing sequence of a university surgical pathology laboratory. | journal = Arch Pathol Lab Med | volume = 135 | issue = 12 | pages = 1561-4 | month = Dec | year = 2011 | doi = 10.5858/arpa.2011-0020-OA | PMID = 22129184 }}</ref> A tissue gain is seen in approximately 25% of cases and a tissue loss is seen in approximately 7% of cases.<ref name=pmid22129184/> | ||
Revision as of 21:37, 10 April 2013
In pathology, tissue loss is when a section at microscopy appears to represent less tissue then one could reasonably expect from the gross. It is relatively common in small biopsies.
It is estimated that approximately 27% of cases have a mismatch between the number of pieces seen at gross and microscopy.[1] A tissue gain is seen in approximately 25% of cases and a tissue loss is seen in approximately 7% of cases.[1]
This article also discusses tissue gain.
Possible cause of tissue gain
- Tissue fragmentation.
- Pseudofragmentation - two piece of tissue appears to be two in the plane of section.
- Tissue floater.
Work-up
- See tissue floater.
Possible causes of tissue loss
- Tissue floated from the slide.
- Material submitted is soluble in the processing medium, e.g. mucous.
Work-up
- Melt the tissue block to looking for the lost tissue.
Sign out
Tissue loss
The block (A1) was melted to look for the missing core tissue; however, no tissue was found. The missing tissue appears to have been lost during processing or it consisted of material that is soluble in the processing fluids and dissolved.
See also
References
- ↑ 1.0 1.1 Owens, SR.; Wiehagen, L.; Simmons, C.; Sikorova, A.; Stewart, W.; Kelly, S.; Nestler, R.; Yousem, SA. (Dec 2011). "Numerical fidelity of endoscopic biopsy fragments in the processing sequence of a university surgical pathology laboratory.". Arch Pathol Lab Med 135 (12): 1561-4. doi:10.5858/arpa.2011-0020-OA. PMID 22129184.