Difference between revisions of "Tissue loss"
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''' | In pathology, '''tissue loss''' is when less tissue is identified at microscopy than at the time of gross. It is relatively common in small biopsies. | ||
It is estimated that approximately 27% of cases have a mismatch between the number of pieces seen at [[gross pathology|gross]] and microscopy.<ref name=pmid22129184>{{Cite journal | last1 = Owens | first1 = SR. | last2 = Wiehagen | first2 = L. | last3 = Simmons | first3 = C. | last4 = Sikorova | first4 = A. | last5 = Stewart | first5 = W. | last6 = Kelly | first6 = S. | last7 = Nestler | first7 = R. | last8 = Yousem | first8 = SA. | title = Numerical fidelity of endoscopic biopsy fragments in the processing sequence of a university surgical pathology laboratory. | journal = Arch Pathol Lab Med | volume = 135 | issue = 12 | pages = 1561-4 | month = Dec | year = 2011 | doi = 10.5858/arpa.2011-0020-OA | PMID = 22129184 }}</ref> A tissue gain is seen in approximately 25% of cases and a tissue loss is seen in approximately 7% of cases.<ref name=pmid22129184/> | It is estimated that approximately 27% of cases have a mismatch between the number of pieces seen at [[gross pathology|gross]] and microscopy.<ref name=pmid22129184>{{Cite journal | last1 = Owens | first1 = SR. | last2 = Wiehagen | first2 = L. | last3 = Simmons | first3 = C. | last4 = Sikorova | first4 = A. | last5 = Stewart | first5 = W. | last6 = Kelly | first6 = S. | last7 = Nestler | first7 = R. | last8 = Yousem | first8 = SA. | title = Numerical fidelity of endoscopic biopsy fragments in the processing sequence of a university surgical pathology laboratory. | journal = Arch Pathol Lab Med | volume = 135 | issue = 12 | pages = 1561-4 | month = Dec | year = 2011 | doi = 10.5858/arpa.2011-0020-OA | PMID = 22129184 }}</ref> A tissue gain is seen in approximately 25% of cases and a tissue loss is seen in approximately 7% of cases.<ref name=pmid22129184/> | ||
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*Pseudofragmentation - two piece of tissue appears to be two in the plane of section. | *Pseudofragmentation - two piece of tissue appears to be two in the plane of section. | ||
*[[Tissue floater]]. | *[[Tissue floater]]. | ||
===Work-up=== | |||
:See ''[[tissue floater]]''. | |||
==Possible causes of tissue loss== | ==Possible causes of tissue loss== | ||
*Tissue floated from the slide. | *Tissue floated from the slide. | ||
*Material submitted soluble in the processing medium, e.g. mucous. | *Material submitted is soluble in the processing medium, e.g. mucous. | ||
===Work-up=== | ===Work-up=== | ||
Revision as of 19:45, 10 April 2013
In pathology, tissue loss is when less tissue is identified at microscopy than at the time of gross. It is relatively common in small biopsies.
It is estimated that approximately 27% of cases have a mismatch between the number of pieces seen at gross and microscopy.[1] A tissue gain is seen in approximately 25% of cases and a tissue loss is seen in approximately 7% of cases.[1]
This article also discusses tissue gain.
Possible cause of tissue gain
- Tissue fragmentation.
- Pseudofragmentation - two piece of tissue appears to be two in the plane of section.
- Tissue floater.
Work-up
- See tissue floater.
Possible causes of tissue loss
- Tissue floated from the slide.
- Material submitted is soluble in the processing medium, e.g. mucous.
Work-up
- Melt the tissue block to looking for the lost tissue.
Sign out
Tissue loss
The block (A1) was melted to look for the missing core tissue; however, no tissue was found. The missing tissue appears to have been lost during processing or it consisted of material that is soluble in the processing fluids and dissolved.
See also
References
- ↑ 1.0 1.1 Owens, SR.; Wiehagen, L.; Simmons, C.; Sikorova, A.; Stewart, W.; Kelly, S.; Nestler, R.; Yousem, SA. (Dec 2011). "Numerical fidelity of endoscopic biopsy fragments in the processing sequence of a university surgical pathology laboratory.". Arch Pathol Lab Med 135 (12): 1561-4. doi:10.5858/arpa.2011-0020-OA. PMID 22129184.