Difference between revisions of "Chronic granulomatous disease"
Jump to navigation
Jump to search
(fix ref) |
|||
| Line 6: | Line 6: | ||
*Five different genetic defects have been identified that cause the disease. | *Five different genetic defects have been identified that cause the disease. | ||
*Individual with the condition have an increased susceptibility to infections. | *Individual with the condition have an increased susceptibility to infections. | ||
*Usually presents in infancy or childhood.<ref name=pmid21624140>{{Cite journal | last1 = Song | first1 = E. | last2 = Jaishankar | first2 = GB. | last3 = Saleh | first3 = H. | last4 = Jithpratuck | first4 = W. | last5 = Sahni | first5 = R. | last6 = Krishnaswamy | first6 = G. | title = Chronic granulomatous disease: a review of the infectious and inflammatory complications. | journal = Clin Mol Allergy | volume = 9 | issue = 1 | pages = 10 | month = | year = 2011 | doi = 10.1186/1476-7961-9-10 | PMID = 21624140 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 22:27, 24 March 2016
Chronic granulomatous disease, abbreviated CGD, is a specific diagnosis; it should not be understood as a granulomatous disease that is of a long duration.
CGD is disorder of neutrophils,[1] and typically leads to widespread granulomas.[2]
General
- Five different genetic defects have been identified that cause the disease.
- Individual with the condition have an increased susceptibility to infections.
- Usually presents in infancy or childhood.[3]
Microscopic
Features:
- Granulomas - see Basics.
DDx:
- Crohn's disease - essentially indistinguishable histomorphologically in the GI tract.[1]
References
- ↑ 1.0 1.1 Marks, DJ.; Miyagi, K.; Rahman, FZ.; Novelli, M.; Bloom, SL.; Segal, AW. (Jan 2009). "Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn's disease.". Am J Gastroenterol 104 (1): 117-24. doi:10.1038/ajg.2008.72. PMID 19098859.
- ↑ Seger RA (November 2010). "Chronic granulomatous disease: recent advances in pathophysiology and treatment". Neth J Med 68 (11): 334–40. PMID 21116026.
- ↑ Song, E.; Jaishankar, GB.; Saleh, H.; Jithpratuck, W.; Sahni, R.; Krishnaswamy, G. (2011). "Chronic granulomatous disease: a review of the infectious and inflammatory complications.". Clin Mol Allergy 9 (1): 10. doi:10.1186/1476-7961-9-10. PMID 21624140.