Difference between revisions of "Fibromatoses"
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*[http://pathinfo.wikia.com/wiki/File:Beta-catenin.fibromatosis.1.jpg Fibromatosis (wikia.com)]. | *[http://pathinfo.wikia.com/wiki/File:Beta-catenin.fibromatosis.1.jpg Fibromatosis (wikia.com)]. | ||
==Sign out== | |||
<pre> | |||
SOFT TISSUE LESION, LEFT SHOULDER, CORE BIOPSY: | |||
- FIBROMATOSIS, SEE COMMENT. | |||
COMMENT: | |||
The lesion was evaluated with immunostains: | |||
Positive: vimentin, SMA (rare), beta-catenin. | |||
Negative: pankeratin, S-100, desmin, CD34 (stains vessels). | |||
</pre> | |||
===Micro=== | |||
The sections show a lesion with bland spindle cells. There is no apparent nuclear atypia. Mitotic figures are not identified. No myxoid areas are apparent. No necrosis is identified. | |||
==See also== | ==See also== | ||
Revision as of 20:37, 6 February 2013
Fibromatoses are a group of benign stromal lesions that may be seen in pediatric pathology and may or may not be associated with syndromes.
Syndromes associated with fibromatoses
- Familial adenomatous polyposis.[1]
- Hereditary desmoid syndrome.
Types
Superficial
- Palmar (Dupuytren's contracture).
- Plantar.
- Penile (Peyronie's disease).
Deep
- Desmoid-type fibromatosis.
- Others.
Gross
- Firm.
- Infiltrative borders.
Image:
Microscopic
Features:
- Bland spindle cells - typically in fascicles.
- Small thin blood vessels that are parallel to one another.
- Nuclei of blood vessels are typically darker staining than those of the lesion.
DDx:
- Metaplastic carcinoma, e.g. metaplastic breast carcinoma.
- Nodular fasciitis.
- Dermatofibroma.
- GIST.
- Desmoplastic fibroblastoma - esp. shoulder region.
Images:
- Plantar fibromatosis (sarcomaimages.com).
- Mesenteric fibromatosis (flickr.com).
- Plantar fibromatosis (rsna.org).[3]
- Plantar fibromatosis (rsna.org).[3]
IHC
- Beta-catenin +ve -- nuclear stain.
- CD117 -ve.
Image:
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SOFT TISSUE LESION, LEFT SHOULDER, CORE BIOPSY: - FIBROMATOSIS, SEE COMMENT. COMMENT: The lesion was evaluated with immunostains: Positive: vimentin, SMA (rare), beta-catenin. Negative: pankeratin, S-100, desmin, CD34 (stains vessels).
Micro
The sections show a lesion with bland spindle cells. There is no apparent nuclear atypia. Mitotic figures are not identified. No myxoid areas are apparent. No necrosis is identified.
See also
References
- ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1092. ISBN 978-1416031215.
- ↑ URL: http://www.histopathology-india.net/Fibromatosis.htm. Accessed on: 18 September 2012.
- ↑ 3.0 3.1 3.2 Murphey, MD.; Ruble, CM.; Tyszko, SM.; Zbojniewicz, AM.; Potter, BK.; Miettinen, M. (Nov 2009). "From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation.". Radiographics 29 (7): 2143-73. doi:10.1148/rg.297095138. PMID 19926768.