Difference between revisions of "Fibromatoses"
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*Beta-catenin +ve.{{fact}} | *Beta-catenin +ve.{{fact}} | ||
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*[http://pathinfo.wikia.com/wiki/File:Beta-catenin.fibromatosis.1.jpg Fibromatosis (wikia.com)]. | |||
==See also== | ==See also== | ||
Revision as of 16:27, 5 November 2012
Fibromatoses are a group of benign stromal lesions that may be seen in pediatric pathology and may or may not be associated with syndromes.
Syndromes associated with fibromatoses
- Familial adenomatous polyposis.[1]
- Hereditary desmoid syndrome.
Types
Superficial
- Palmar (Dupuytren's contracture).
- Plantar.
- Penile (Peyronie's disease).
Deep
- Desmoid-type fibromatosis.
- Others.
Gross
- Firm.
- Infiltrative borders.
Image:
Microscopic
Features:
- Bland spindle cells - typically in fascicles.
- Pale eosinophilic cytoplasm.[2]
- Small thin blood vessels that are parallel to one another.
- Nuclei of blood vessels are typically darker staining than those of the lesion.
DDx:
- Metaplastic carcinoma, e.g. metaplastic breast carcinoma.
- Nodular fasciitis.
- Dermatofibroma.
- GIST.
Image:
IHC
- Beta-catenin +ve.[citation needed]
- CD117 -ve.
Image:
See also
References
- ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1092. ISBN 978-1416031215.
- ↑ URL: http://www.histopathology-india.net/Fibromatosis.htm. Accessed on: 18 September 2012.