Difference between revisions of "Tumour regression"

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(more BCC, nevi)
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May occur in:
May occur in:
*[[Basal cell carcinoma]].<ref name=Ref_Derm476>{{Ref Derm|476}}</ref>
*[[Basal cell carcinoma]].<ref name=Ref_Derm476>{{Ref Derm|476}}</ref>
*[[Melanocytic nevi]].<ref name=Ref_Derm476>{{Ref Derm|476}}</ref>
 
Note:
*Melanocytic lesions in general, ''not'' only melanoma, may regress.<ref name=Ref_Derm476>{{Ref Derm|476}}</ref><ref name=pmid21029398>{{Cite journal  | last1 = Speeckaert | first1 = R. | last2 = van Geel | first2 = N. | last3 = Vermaelen | first3 = KV. | last4 = Lambert | first4 = J. | last5 = Van Gele | first5 = M. | last6 = Speeckaert | first6 = MM. | last7 = Brochez | first7 = L. | title = Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy. | journal = Pigment Cell Melanoma Res | volume = 24 | issue = 2 | pages = 334-44 | month = Apr | year = 2011 | doi = 10.1111/j.1755-148X.2010.00799.x | PMID = 21029398 }}</ref><ref name=Ref_Derm476>{{Ref Derm|476}}</ref>


==Microscopic==
==Microscopic==

Revision as of 01:51, 28 August 2012

Tumour regression can occur as a consequence of treatment or sporadically.

Sporadic tumour regression

Well-known:

May occur in:

Note:

  • Melanocytic lesions in general, not only melanoma, may regress.[2][3][2]

Microscopic

Features:

  • +/-Fibrosis.
  • +/-Mucin.
  • +/-Inflammation.

Grading of tumour regression

There is a three tiered regression grading system by Ryan et al.[4]

Note:

References

  1. Balzer, BL.; Ulbright, TM. (Jul 2006). "Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases.". Am J Surg Pathol 30 (7): 858-65. doi:10.1097/01.pas.0000209831.24230.56. PMID 16819328.
  2. 2.0 2.1 2.2 Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 476. ISBN 978-0443066542.
  3. Speeckaert, R.; van Geel, N.; Vermaelen, KV.; Lambert, J.; Van Gele, M.; Speeckaert, MM.; Brochez, L. (Apr 2011). "Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy.". Pigment Cell Melanoma Res 24 (2): 334-44. doi:10.1111/j.1755-148X.2010.00799.x. PMID 21029398.
  4. Ryan, R.; Gibbons, D.; Hyland, JM.; Treanor, D.; White, A.; Mulcahy, HE.; O'Donoghue, DP.; Moriarty, M. et al. (Aug 2005). "Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer.". Histopathology 47 (2): 141-6. doi:10.1111/j.1365-2559.2005.02176.x. PMID 16045774.