Difference between revisions of "P63"
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'''p63''' is a commonly used [[immunostain]]. | '''p63''' is a commonly used [[immunostain]]. p63, like most other "p" stains, is a nuclear stain. | ||
==Pattern== | |||
*Nuclear staining. | |||
Note: | |||
*Cytoplasmic staining suggestive of muscle differentiation - seen in [[rhabdomyosarcoma]].<ref name=pmid21623385>{{Cite journal | last1 = Martin | first1 = SE. | last2 = Temm | first2 = CJ. | last3 = Goheen | first3 = MP. | last4 = Ulbright | first4 = TM. | last5 = Hattab | first5 = EM. | title = Cytoplasmic p63 immunohistochemistry is a useful marker for muscle differentiation: an immunohistochemical and immunoelectron microscopic study. | journal = Mod Pathol | volume = 24 | issue = 10 | pages = 1320-6 | month = Oct | year = 2011 | doi = 10.1038/modpathol.2011.89 | PMID = 21623385 }}</ref> | |||
==Classic use== | ==Classic use== | ||
| Line 10: | Line 16: | ||
==Non-classic tumours== | ==Non-classic tumours== | ||
*Di Como ''et al''<ref name=pmid11839669>{{Cite journal | last1 = Di Como | first1 = CJ. | last2 = Urist | first2 = MJ. | last3 = Babayan | first3 = I. | last4 = Drobnjak | first4 = M. | last5 = Hedvat | first5 = CV. | last6 = Teruya-Feldstein | first6 = J. | last7 = Pohar | first7 = K. | last8 = Hoos | first8 = A. | last9 = Cordon-Cardo | first9 = C. | title = p63 expression profiles in human normal and tumor tissues. | journal = Clin Cancer Res | volume = 8 | issue = 2 | pages = 494-501 | month = Feb | year = 2002 | doi = | PMID = 11839669 }}</ref> looked at a large cross-section of | *Di Como ''et al''<ref name=pmid11839669>{{Cite journal | last1 = Di Como | first1 = CJ. | last2 = Urist | first2 = MJ. | last3 = Babayan | first3 = I. | last4 = Drobnjak | first4 = M. | last5 = Hedvat | first5 = CV. | last6 = Teruya-Feldstein | first6 = J. | last7 = Pohar | first7 = K. | last8 = Hoos | first8 = A. | last9 = Cordon-Cardo | first9 = C. | title = p63 expression profiles in human normal and tumor tissues. | journal = Clin Cancer Res | volume = 8 | issue = 2 | pages = 494-501 | month = Feb | year = 2002 | doi = | PMID = 11839669 }}</ref> looked at a large cross-section of tumours. | ||
*Jo and Fletcher<ref name=pmid22031315>{{Cite journal | last1 = Jo | first1 = VY. | last2 = Fletcher | first2 = CD. | title = p63 immunohistochemical staining is limited in soft tissue tumors. | journal = Am J Clin Pathol | volume = 136 | issue = 5 | pages = 762-6 | month = Nov | year = 2011 | doi = 10.1309/AJCPXNUC7JZSKWEU | PMID = 22031315 }}</ref> did a paper on [[soft tissue lesions]] and p63. | *Jo and Fletcher<ref name=pmid22031315>{{Cite journal | last1 = Jo | first1 = VY. | last2 = Fletcher | first2 = CD. | title = p63 immunohistochemical staining is limited in soft tissue tumors. | journal = Am J Clin Pathol | volume = 136 | issue = 5 | pages = 762-6 | month = Nov | year = 2011 | doi = 10.1309/AJCPXNUC7JZSKWEU | PMID = 22031315 }}</ref> did a paper on [[soft tissue lesions]] and p63. | ||
Revision as of 13:18, 29 August 2012
p63 is a commonly used immunostain. p63, like most other "p" stains, is a nuclear stain.
Pattern
- Nuclear staining.
Note:
- Cytoplasmic staining suggestive of muscle differentiation - seen in rhabdomyosarcoma.[1]
Classic use
Subtype marker:
- Marker of squamous cell carcinoma.
Thresholding (invasive vs. pre-invasive):
- Prostate basal cell marker.
- Breast myoepithelial cell marker.
Non-classic tumours
- Di Como et al[2] looked at a large cross-section of tumours.
- Jo and Fletcher[3] did a paper on soft tissue lesions and p63.
References
- ↑ Martin, SE.; Temm, CJ.; Goheen, MP.; Ulbright, TM.; Hattab, EM. (Oct 2011). "Cytoplasmic p63 immunohistochemistry is a useful marker for muscle differentiation: an immunohistochemical and immunoelectron microscopic study.". Mod Pathol 24 (10): 1320-6. doi:10.1038/modpathol.2011.89. PMID 21623385.
- ↑ Di Como, CJ.; Urist, MJ.; Babayan, I.; Drobnjak, M.; Hedvat, CV.; Teruya-Feldstein, J.; Pohar, K.; Hoos, A. et al. (Feb 2002). "p63 expression profiles in human normal and tumor tissues.". Clin Cancer Res 8 (2): 494-501. PMID 11839669.
- ↑ Jo, VY.; Fletcher, CD. (Nov 2011). "p63 immunohistochemical staining is limited in soft tissue tumors.". Am J Clin Pathol 136 (5): 762-6. doi:10.1309/AJCPXNUC7JZSKWEU. PMID 22031315.