Difference between revisions of "Mucinous carcinoma"
Jump to navigation
Jump to search
(re-wrok) |
(prognosis -- PMID REF) |
||
| Line 4: | Line 4: | ||
==General== | ==General== | ||
* | Prognostic significance dependent on the primary site: | ||
*[[Mucinous breast carcinoma|Breast mucinous carcinoma]] has a better prognosis. | |||
*Colorectal mucinous carcinoma has a worse prognosis.<ref name=pmid22476818>PMID 22476818.</ref> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 19:14, 13 August 2012
Mucinous carcinoma is an epithelial neoplasm that produces mucin.
Mucinous carcinoma can arise in a number of sites.
General
Prognostic significance dependent on the primary site:
- Breast mucinous carcinoma has a better prognosis.
- Colorectal mucinous carcinoma has a worse prognosis.[1]
Microscopic
Features:
- Mucin - amphormous whispy or cream material.
- Cytologically atypical cells within the mucin.
- +/-Tumour without mucin.
- Maximum amount acceptable depends on the primary site (see proportion of mucin section below).
Note:
- Mucin alone -- should prompt a search for atypical cells, i.e. levels should be done.
DDx:
- Benign mucocele.
- Adenocarcinoma with mucinous features.
Proportion of mucin
The criteria for diagnosing "mucinous carcinoma" varies by the anatomical site:
- Mucinous prostate carcinoma: > 25% of the tumour.[2]
- Mucinous colorectal carcinoma: > 50% of the tumour.[3]
- Mucinous gastric carcinoma: > 50% of the tumour.
- Mucinous breast carcinoma: > 90% of the tumour.[4]
- One source suggests: > 50% of the tumour.[5]
See also
References
- ↑ PMID 22476818.
- ↑ Grignon DJ (March 2004). "Unusual subtypes of prostate cancer". Mod. Pathol. 17 (3): 316–27. doi:10.1038/modpathol.3800052. PMID 14976541.
- ↑ Tozawa E, Ajioka Y, Watanabe H, et al. (2007). "Mucin expression, p53 overexpression, and peritumoral lymphocytic infiltration of advanced colorectal carcinoma with mucus component: is mucinous carcinoma a distinct histological entity?". Pathol. Res. Pract. 203 (8): 567–74. doi:10.1016/j.prp.2007.04.013. PMID 17679024.
- ↑ Dogan, E.; Aksoy, S.; Dizdar, O.; Arslan, C.; Dede, DS.; Ozisik, Y.; Altundag, K.. "Pure mucinous carcinoma of the breast: a single center experience.". J BUON 16 (3): 565-7. PMID 22006768.
- ↑ Park S, Koo J, Kim JH, Yang WI, Park BW, Lee KS (March 2010). "Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: comparison with invasive ductal carcinoma-not otherwise specified". J. Korean Med. Sci. 25 (3): 361–8. doi:10.3346/jkms.2010.25.3.361. PMC 2826751. PMID 20191033. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826751/.