Difference between revisions of "Non-specific interstitial pneumonia"
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'''Non-specific interstitial pneumonia''', abbreviated '''NSIP''', is an uncommon type of [[diffuse lung disease]]. | |||
==General== | |||
*Better prognosis than [[UIP]]. | |||
*Some radiologists and pathologists don't believe in this entity. | |||
Associations:<ref name=Ref_WMSP92>{{Ref WMSP|92}}</ref> | |||
*Connective tissue disease. | |||
*[[Rheumatoid arthritis]]. | |||
==Gross/Radiology== | |||
*No honeycombing. | |||
*Fibrosis usually lower lung zone. | |||
*Patchy ground glass. | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP92>{{Ref WMSP|92}}</ref> | |||
*Diffuse fibrosis: | |||
**Uniform fibrosis (unlike [[UIP]]). | |||
**"Linear fibrosis" has a good prognosis - should be mentioned in the report. | |||
***''Linear fibrosis'' = fibrosis that follows alveolar walls + no architectural distortion. | |||
*+/-Lymphoid nodules - association with collagen vascular disease. (???) | |||
*+/-Focal [[organizing pneumonia]]. | |||
Notes: | |||
*Inflammation in NSIP usually more prominent than in UIP. | |||
*No honeycombing - key difference between UIP and NSIP. | |||
DDx: | |||
*Collagen vascular disease. | |||
*Drug reaction. | |||
*[[Hypersensitivity pneumonitis]] (extrinic allergic alveolitis). | |||
*[[Lymphocytic interstitial pneumonia]] (LIP) - much more inflammation. | |||
==See also== | |||
*[[Diffuse lung diseases]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Diffuse lung diseases]] | |||
Revision as of 03:52, 31 May 2014
Non-specific interstitial pneumonia, abbreviated NSIP, is an uncommon type of diffuse lung disease.
General
- Better prognosis than UIP.
- Some radiologists and pathologists don't believe in this entity.
Associations:[1]
- Connective tissue disease.
- Rheumatoid arthritis.
Gross/Radiology
- No honeycombing.
- Fibrosis usually lower lung zone.
- Patchy ground glass.
Microscopic
Features:[1]
- Diffuse fibrosis:
- Uniform fibrosis (unlike UIP).
- "Linear fibrosis" has a good prognosis - should be mentioned in the report.
- Linear fibrosis = fibrosis that follows alveolar walls + no architectural distortion.
- +/-Lymphoid nodules - association with collagen vascular disease. (???)
- +/-Focal organizing pneumonia.
Notes:
- Inflammation in NSIP usually more prominent than in UIP.
- No honeycombing - key difference between UIP and NSIP.
DDx:
- Collagen vascular disease.
- Drug reaction.
- Hypersensitivity pneumonitis (extrinic allergic alveolitis).
- Lymphocytic interstitial pneumonia (LIP) - much more inflammation.
See also
References
- ↑ 1.0 1.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 92. ISBN 978-0781765275.