Difference between revisions of "Post-infectious glomerulonephritis"

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#redirect [[Medical_kidney_diseases#Post-infectious_glomerulonephritis]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Post-infectious_glomerulonephritis_-_very_high_mag.jpg
| Width      =
| Caption    = Post-infectious glomerulonephritis. [[H&E stain]].
| Synonyms  =
| Micro      = +/-neutrophils in glomerulus, [[glomerular crescents]]
| Subtypes  =
| LMDDx      =
| Stains    =
| IHC        =
| EM        = subepithelial deposits, hump-like
| Molecular  =
| IF        = granular immune deposits
| Gross      =
| Grossing  =
| Site      = [[kidney]] - see ''[[medical kidney diseases]]''
| Assdx      = post-infection, e.g. [[pneumonia]]
| Syndromes  =
| Clinicalhx =
| Signs      = [[nephritic syndrome]] (proteinuria, [[hypertension]], azotemia, [[RBC]] casts, oliguria, hematuria)
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = usually good
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Post-infectious glomerulonephritis''', abbreviated '''PIGN''', is a rarely biopsied glomerulonephritis classically associated with a streptococcal infection.
 
==General==
*Classically post-streptococcal infection.<ref name=pmid12746805>{{Cite journal  | last1 = Barbiano Di Belgiojoso | first1 = G. | last2 = Genderini | first2 = A. | last3 = Ferrario | first3 = F. | title = [Post-infectious glomerulonephritis]. | journal = G Ital Nefrol | volume = 20 | issue = 2 | pages = 184-99 | month =  | year =  | doi =  | PMID = 12746805 }}</ref><ref name=pmid24777751/>
**Lab test: Antistreptolysin O titer (ASOT) +ve.
 
Clinical:
*[[Nephritic syndrome]].<ref name=pmid24777751>{{Cite journal  | last1 = Stratta | first1 = P. | last2 = Musetti | first2 = C. | last3 = Barreca | first3 = A. | last4 = Mazzucco | first4 = G. | title = New trends of an old disease: the acute post infectious glomerulonephritis at the beginning of the new millenium. | journal = J Nephrol | volume = 27 | issue = 3 | pages = 229-39 | month = Jun | year = 2014 | doi = 10.1007/s40620-013-0018-z | PMID = 24777751 }}</ref>
 
==Microscopic==
Features:
*+/-Neutrophils - in glomerulus.
*[[Glomerular crescents]].
 
===Images===
<gallery>
Image:Post-infectious_glomerulonephritis_-_high_mag.jpg | Post-infectious GN - high mag. (WC/Nephron)
Image:Post-infectious_glomerulonephritis_-_very_high_mag.jpg | Post-infectious GN - very high mag. (WC/Nephron)
Image:Acute_Glomerulonephritis_Pathology_Diagram.svg | Post-infectious GN - schematic (WC/Nephron)
</gallery>
www:
*[http://path.upmc.edu/cases/case671.html Post-infectious glomerulonephritis - several images (upmc.edu)].
 
==IF==
*Granular immune deposits.
 
==EM==
*Subepithelial deposits - hump-like.<ref name=pmid18162726>{{Cite journal  | last1 = Sung | first1 = HY. | last2 = Lim | first2 = CH. | last3 = Shin | first3 = MJ. | last4 = Kim | first4 = BS. | last5 = Kim | first5 = YO. | last6 = Song | first6 = HC. | last7 = Kim | first7 = SY. | last8 = Choi | first8 = EJ. | last9 = Chang | first9 = YS. | title = A case of post-streptococcal glomerulonephritis with diffuse alveolar hemorrhage. | journal = J Korean Med Sci | volume = 22 | issue = 6 | pages = 1074-8 | month = Dec | year = 2007 | doi =  | PMID = 18162726 }}</ref>
**Larger when measured perpendicular to the basement membrane, if compared to [[membranous nephropathy]].
**Typically focal.
 
==See also==
*[[Medical kidney diseases]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Medical kidney pathology]]

Latest revision as of 06:24, 11 April 2015

Post-infectious glomerulonephritis
Diagnosis in short

Post-infectious glomerulonephritis. H&E stain.
LM +/-neutrophils in glomerulus, glomerular crescents
EM subepithelial deposits, hump-like
IF granular immune deposits
Site kidney - see medical kidney diseases
Associated Dx post-infection, e.g. pneumonia
Signs nephritic syndrome (proteinuria, hypertension, azotemia, RBC casts, oliguria, hematuria)
Prevalence uncommon
Prognosis usually good

Post-infectious glomerulonephritis, abbreviated PIGN, is a rarely biopsied glomerulonephritis classically associated with a streptococcal infection.

General

  • Classically post-streptococcal infection.[1][2]
    • Lab test: Antistreptolysin O titer (ASOT) +ve.

Clinical:

Microscopic

Features:

Images

  • Post-infectious GN - high mag. (WC/Nephron)

  • Post-infectious GN - very high mag. (WC/Nephron)

  • Post-infectious GN - schematic (WC/Nephron)

www:

IF

  • Granular immune deposits.

EM

  • Subepithelial deposits - hump-like.[3]
    • Larger when measured perpendicular to the basement membrane, if compared to membranous nephropathy.
    • Typically focal.

See also

References

  1. ↑ Barbiano Di Belgiojoso, G.; Genderini, A.; Ferrario, F.. "[Post-infectious glomerulonephritis].". G Ital Nefrol 20 (2): 184-99. PMID 12746805.
  2. ↑ 2.0 2.1 Stratta, P.; Musetti, C.; Barreca, A.; Mazzucco, G. (Jun 2014). "New trends of an old disease: the acute post infectious glomerulonephritis at the beginning of the new millenium.". J Nephrol 27 (3): 229-39. doi:10.1007/s40620-013-0018-z. PMID 24777751.
  3. ↑ Sung, HY.; Lim, CH.; Shin, MJ.; Kim, BS.; Kim, YO.; Song, HC.; Kim, SY.; Choi, EJ. et al. (Dec 2007). "A case of post-streptococcal glomerulonephritis with diffuse alveolar hemorrhage.". J Korean Med Sci 22 (6): 1074-8. PMID 18162726.
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