Difference between revisions of "Granuloma annulare"

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#redirect [[Non-malignant_skin_disease#Granuloma_annulare]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Granuloma_annulare_-_add_-_high_mag.jpg
| Width      =
| Caption    = Granuloma annulare. [[H&E stain]].
| Micro      = Palisading granulomas around necrobiotic collagen and mucin
| Subtypes  = superficial (common), deep (not common)
| LMDDx      = [[rheumatoid nodule]], [[necrobiosis lipoidica]], [[epithelioid sarcoma]]
| Stains    = [[alcian blue stain]] (pH 2.5)
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      = usu. arms and hands, papules
| Grossing  =
| Site      = [[skin]] - esp. antecubital fossae
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence =
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    =
}}
'''Granuloma annulare''' is relatively uncommon problem in [[dermatopathology]].
 
==General==
*Benign and self-limited condition.
*Etiology unknown - may be assoc. with trauma.<ref name=Ref_Derm51>{{Ref Derm|51}}</ref>
**Associations: trauma, infections, diabetes mellitus, dyslipidemia, thyroid disease, malignancy, medications.<ref name=pmid32941717>{{cite journal |authors=Fox JD, Aramin H, Ghiam N, Freedman JB, Romanelli P |title=Secukinumab-associated localized granuloma annulare (SAGA): a case report and review of the literature |journal=Dermatol Online J |volume=26 |issue=8 |pages= |date=August 2020 |pmid=32941717 |doi= |url=}}</ref>
*A deep GA can mimic a [[rheumatoid nodule]]; may be called a ''pseudorheumatoid nodule''.<ref>{{Cite journal  | last1 = Barzilai | first1 = A. | last2 = Huszar | first2 = M. | last3 = Shpiro | first3 = D. | last4 = Nass | first4 = D. | last5 = Trau | first5 = H. | title = Pseudorheumatoid nodules in adults: a juxta-articular form of nodular granuloma annulare. | journal = Am J Dermatopathol | volume = 27 | issue = 1 | pages = 1-5 | month = Feb | year = 2005 | doi =  | PMID = 15677968 }}</ref>
 
==Gross==
*Typically extremities - usu. arms and hands.<ref name=Ref_Derm51>{{Ref Derm|51}}</ref>
 
===Image===
<gallery>
Image:Granuloma_annulare.jpg | Granuloma annulare. (WC)
</gallery>
 
==Gross==
*Antecubital fossae.<ref name=pmid32941717/>
 
==Microscopic==
Features:<ref name=Ref_WMSP478>{{Ref WMSP|478}}</ref>
*Dermal palisading [[granuloma]] - typically superficial-to-mid dermis - surrounds:
**Necrotic collagen - '''key feature'''.
***Nuclei "missing" - have undergone karyolysis.
**Mucin - important.
***Loose/pale, paucicellular, eosinophilic.
*Chronic inflammatory cells.
 
Notes:
#There may be multiple small foci with intervening normal dermis.<ref name=Ref_Derm51>{{Ref Derm|51}}</ref>
#Granuloma annulare can be subclassified into ''subcutaneous'' and ''interstitial''.
#Histomorphologically similar to ''[[Rheumatoid nodule]].
#[[Neutrophil]]s may be seen.<ref name=pmid17544961>{{Cite journal  | last1 = Requena | first1 = L. | last2 = Fernández-Figueras | first2 = MT. | title = Subcutaneous granuloma annulare. | journal = Semin Cutan Med Surg | volume = 26 | issue = 2 | pages = 96-9 | month = Jun | year = 2007 | doi = 10.1016/j.sder.2007.02.006 | PMID = 17544961 }}</ref>
 
DDx:
*[[Necrobiosis lipoidica]] - little mucin, no normal dermis between foci,<ref name=Ref_Derm51>{{Ref Derm|51}}</ref> plasma cells - common,<ref name=dermnetnz_nl>URL: [http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html]. Accessed on: 24 January 2012.</ref> may involve the fat - tend to be deeper.
*[[Rheumatoid nodule]] - has fibrin in the core of the granuloma (instead of mucin), multinucleated macrophages more common.<ref name=Ref_Derm52-3>{{Ref Derm|52-3}}</ref>
*[[Epithelioid sarcoma]] - esp. if the lesion appears to be mid-to-deep dermis.
*Tattoo reaction (granuloma annulare-like) - case report.<ref>{{Cite journal  | last1 = Bagwan | first1 = IN. | last2 = Walker | first2 = M. | last3 = Theaker | first3 = JM. | title = Granuloma annulare-like tattoo reaction. | journal = J Cutan Pathol | volume = 34 | issue = 10 | pages = 804-5 | month = Oct | year = 2007 | doi = 10.1111/j.1600-0560.2006.00666.x | PMID = 17880589 }}</ref>
 
===Images===
<gallery>
Image:Granuloma_annulare_-_add_-_intermed_mag.jpg | Granuloma annulare - intermed. mag. (WC/Nephron)
Image:Granuloma_annulare_-_high_mag.jpg | Granuloma annulare - high mag. (WC/Nephron)
Image:Granuloma_annulare_-_add_-_high_mag.jpg | Granuloma annular - palisaded granuloma - high mag. (WC/Nephron)
</gallery>
www:
*[http://www.dermaamin.com/site/histopathology-of-the-skin/61-i/1813-interstitial-granuloma-annulare-.html Granuloma annulare (dermaamin.com)].
 
==Stains==
*[[Alcian blue stain|Alcian blue]] (pH 2.5) +ve (for mucin).<ref name=pmid20523767/><ref name=Ref_Derm51>{{Ref Derm|51}}</ref>
 
Image:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861218/figure/F7/ Granuloma annulare (nih.gov)].<ref name=pmid20523767>{{Cite journal  | last1 = Yun | first1 = JH. | last2 = Lee | first2 = JY. | last3 = Kim | first3 = MK. | last4 = Seo | first4 = YJ. | last5 = Kim | first5 = MH. | last6 = Cho | first6 = KH. | last7 = Kim | first7 = MB. | last8 = Lee | first8 = WS. | last9 = Lee | first9 = KH. | title = Clinical and pathological features of generalized granuloma annulare with their correlation: a retrospective multicenter study in Korea. | journal = Ann Dermatol | volume = 21 | issue = 2 | pages = 113-9 | month = May | year = 2009 | doi = 10.5021/ad.2009.21.2.113 | PMID = 20523767 | PMC = 2861218 }}</ref>
 
==IHC==
*CD68 +ve.
*Factor XIIIa +ve<ref name=pmid16132226>{{Cite journal  | last1 = Töröcsik | first1 = D. | last2 = Bárdos | first2 = H. | last3 = Nagy | first3 = L. | last4 = Adány | first4 = R. | title = Identification of factor XIII-A as a marker of alternative macrophage activation. | journal = Cell Mol Life Sci | volume = 62 | issue = 18 | pages = 2132-9 | month = Sep | year = 2005 | doi = 10.1007/s00018-005-5242-9 | PMID = 16132226 }}</ref> -- nuclear.<ref name=pmid11372678>{{Cite journal  | last1 = Adány | first1 = R. | last2 = Bárdos | first2 = H. | last3 = Antal | first3 = M. | last4 = Módis | first4 = L. | last5 = Sárváry | first5 = A. | last6 = Szücs | first6 = S. | last7 = Balogh | first7 = I. | title = Factor XIII of blood coagulation as a nuclear crosslinking enzyme. | journal = Thromb Haemost | volume = 85 | issue = 5 | pages = 845-51 | month = May | year = 2001 | doi =  | PMID = 11372678 }}</ref>
 
Note:
*Not routinely used.
 
==Sign out==
<pre>
SKIN LESION, UPPER BACK, PUNCH BIOPSY:
- SUPERFICIAL PALISADING GRANULOMAS WITH CORES OF NECROBIOTIC COLLAGEN, AND SCANT
  MUCIN; CONSISTENT WITH GRANULOMA ANNULARE.
</pre>
 
<pre>
Skin lesion, left elbow, excision:
- Palisading granulomas with cores of necrobiotic collagen, and scant mucin
  consistent with granuloma annulare.
 
COMMENT:
An alcian-blue stain (pH 2.5) shows scant mucin.  The granulomas are relatively deep;
however, plasma cells are not apparent. The differential diagnosis is rheumatoid nodule.
</pre>
 
===Micro===
The sections show hair bearing skin with superficial palisading granuloma with cores of necrobiotic collagen and mucin. Plasma cells are not apparent in association with the lesion.
 
The overlying epidermis matures normally to the surface and has no basal atypia.
 
==See also==
*[[Dermatopathology]].
*[[Non-malignant skin disease]].
 
==References==
{{Reflist|1}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Dermatopathology]]

Latest revision as of 12:26, 6 October 2022

Granuloma annulare
Diagnosis in short

Granuloma annulare. H&E stain.
LM Palisading granulomas around necrobiotic collagen and mucin
Subtypes superficial (common), deep (not common)
LM DDx rheumatoid nodule, necrobiosis lipoidica, epithelioid sarcoma
Stains alcian blue stain (pH 2.5)
Gross usu. arms and hands, papules
Site skin - esp. antecubital fossae
Prognosis benign

Granuloma annulare is relatively uncommon problem in dermatopathology.

General

  • Benign and self-limited condition.
  • Etiology unknown - may be assoc. with trauma.[1]
    • Associations: trauma, infections, diabetes mellitus, dyslipidemia, thyroid disease, malignancy, medications.[2]
  • A deep GA can mimic a rheumatoid nodule; may be called a pseudorheumatoid nodule.[3]

Gross

  • Typically extremities - usu. arms and hands.[1]

Image

  • Granuloma annulare. (WC)

Gross

  • Antecubital fossae.[2]

Microscopic

Features:[4]

  • Dermal palisading granuloma - typically superficial-to-mid dermis - surrounds:
    • Necrotic collagen - key feature.
      • Nuclei "missing" - have undergone karyolysis.
    • Mucin - important.
      • Loose/pale, paucicellular, eosinophilic.
  • Chronic inflammatory cells.

Notes:

  1. There may be multiple small foci with intervening normal dermis.[1]
  2. Granuloma annulare can be subclassified into subcutaneous and interstitial.
  3. Histomorphologically similar to Rheumatoid nodule.
  4. Neutrophils may be seen.[5]

DDx:

  • Necrobiosis lipoidica - little mucin, no normal dermis between foci,[1] plasma cells - common,[6] may involve the fat - tend to be deeper.
  • Rheumatoid nodule - has fibrin in the core of the granuloma (instead of mucin), multinucleated macrophages more common.[7]
  • Epithelioid sarcoma - esp. if the lesion appears to be mid-to-deep dermis.
  • Tattoo reaction (granuloma annulare-like) - case report.[8]

Images

  • Granuloma annulare - intermed. mag. (WC/Nephron)

  • Granuloma annulare - high mag. (WC/Nephron)

  • Granuloma annular - palisaded granuloma - high mag. (WC/Nephron)

www:

Stains

Image:

IHC

  • CD68 +ve.
  • Factor XIIIa +ve[10] -- nuclear.[11]

Note:

  • Not routinely used.

Sign out

SKIN LESION, UPPER BACK, PUNCH BIOPSY:
- SUPERFICIAL PALISADING GRANULOMAS WITH CORES OF NECROBIOTIC COLLAGEN, AND SCANT
  MUCIN; CONSISTENT WITH GRANULOMA ANNULARE.

Skin lesion, left elbow, excision:
- Palisading granulomas with cores of necrobiotic collagen, and scant mucin
  consistent with granuloma annulare.

COMMENT:
An alcian-blue stain (pH 2.5) shows scant mucin.  The granulomas are relatively deep;
however, plasma cells are not apparent. The differential diagnosis is rheumatoid nodule.

Micro

The sections show hair bearing skin with superficial palisading granuloma with cores of necrobiotic collagen and mucin. Plasma cells are not apparent in association with the lesion.

The overlying epidermis matures normally to the surface and has no basal atypia.

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 51. ISBN 978-0443066542.
  2. ↑ 2.0 2.1 Fox JD, Aramin H, Ghiam N, Freedman JB, Romanelli P (August 2020). "Secukinumab-associated localized granuloma annulare (SAGA): a case report and review of the literature". Dermatol Online J 26 (8). PMID 32941717.
  3. ↑ Barzilai, A.; Huszar, M.; Shpiro, D.; Nass, D.; Trau, H. (Feb 2005). "Pseudorheumatoid nodules in adults: a juxta-articular form of nodular granuloma annulare.". Am J Dermatopathol 27 (1): 1-5. PMID 15677968.
  4. ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 478. ISBN 978-0781765275.
  5. ↑ Requena, L.; Fernández-Figueras, MT. (Jun 2007). "Subcutaneous granuloma annulare.". Semin Cutan Med Surg 26 (2): 96-9. doi:10.1016/j.sder.2007.02.006. PMID 17544961.
  6. ↑ URL: http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html. Accessed on: 24 January 2012.
  7. ↑ Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 52-3. ISBN 978-0443066542.
  8. ↑ Bagwan, IN.; Walker, M.; Theaker, JM. (Oct 2007). "Granuloma annulare-like tattoo reaction.". J Cutan Pathol 34 (10): 804-5. doi:10.1111/j.1600-0560.2006.00666.x. PMID 17880589.
  9. ↑ 9.0 9.1 Yun, JH.; Lee, JY.; Kim, MK.; Seo, YJ.; Kim, MH.; Cho, KH.; Kim, MB.; Lee, WS. et al. (May 2009). "Clinical and pathological features of generalized granuloma annulare with their correlation: a retrospective multicenter study in Korea.". Ann Dermatol 21 (2): 113-9. doi:10.5021/ad.2009.21.2.113. PMC 2861218. PMID 20523767. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861218/.
  10. ↑ Töröcsik, D.; Bárdos, H.; Nagy, L.; Adány, R. (Sep 2005). "Identification of factor XIII-A as a marker of alternative macrophage activation.". Cell Mol Life Sci 62 (18): 2132-9. doi:10.1007/s00018-005-5242-9. PMID 16132226.
  11. ↑ Adány, R.; Bárdos, H.; Antal, M.; Módis, L.; Sárváry, A.; Szücs, S.; Balogh, I. (May 2001). "Factor XIII of blood coagulation as a nuclear crosslinking enzyme.". Thromb Haemost 85 (5): 845-51. PMID 11372678.
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