Difference between revisions of "Granulomatous appendicitis"

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#redirect [[Vermiform_appendix#Granulomatous_appendicitis]]
'''Granulomatous appendicitis''' is an inflammatory process involving the [[vermiform appendix]] characterized by [[granulomas]].
 
''Interval appendectomy'' redirects to this article, as granulomas are often seen in that context.
 
==General==
Most common cause:
*Yersinia appendicitis.<ref name=pmid11257626>{{cite journal |author=Lamps LW, Madhusudhan KT, Greenson JK, ''et al.'' |title=The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study |journal=Am. J. Surg. Pathol. |volume=25 |issue=4 |pages=508–15 |year=2001 |month=April |pmid=11257626 |doi= |url=}}</ref>
 
DDx:<ref>[http://granuloma.homestead.com/appendicitis.html http://granuloma.homestead.com/appendicitis.html]</ref>
*Yersinia appendicitis.<ref name=pmid11257626>{{cite journal |author=Lamps LW, Madhusudhan KT, Greenson JK, ''et al.'' |title=The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study |journal=Am. J. Surg. Pathol. |volume=25 |issue=4 |pages=508–15 |year=2001 |month=April |pmid=11257626 |doi= |url=}}</ref>
**Yersinia = gram negative rod (red on [[Gram stain]]).
**"Safety pin"-like appearance<ref>URL: [http://www.cdc.gov/ncidod/dvbid/plague/p1.htm http://www.cdc.gov/ncidod/dvbid/plague/p1.htm]. Accessed on: 30 June 2011.</ref> - approximately 0.5 micrometers diameter x 2 micrometers length.
*Other micro-organism ([[TB]], fungus).
*[[Crohn's disease]].
*[[Sarcoidosis]].
*Foreign body reaction.
*Interval (delayed) appendectomy.
**Approximately 60% of delayed appendectomies have granulomas.<ref name=pmid12883248>{{Cite journal  | last1 = Guo | first1 = G. | last2 = Greenson | first2 = JK. | title = Histopathology of interval (delayed) appendectomy specimens: strong association with granulomatous and xanthogranulomatous appendicitis. | journal = Am J Surg Pathol | volume = 27 | issue = 8 | pages = 1147-51 | month = Aug | year = 2003 | doi =  | PMID = 12883248 }}</ref>
 
==Microscopic==
Features:
*[[Granulomas]].
*+/-"Safety pin"-like organisms (Yersinia).
 
Image(s):
<gallery>
Image:Appendix Appendicitis Acute Granulomatous 2 PA.JPG|Granulomatous Appendicitis (SKB)
Image:Appendix Appendicitis Acute Granulomatous PA.JPG|Suppurating Granulomatous Appendicitis (SKB)
Image:Appendix Appendicitis GranulomatousSuppurating Yersinia-LP PA.JPG|Suppurating Granulomatous Yersinia Appendicitis (SKB)
Image:Appendix Appendicitis GranulomatousSuppurating Yersinia-HP PA.JPG|Suppurating Granulomatous Yersinia Appendicitis  Yersinia(SKB)
</gallery>
 
==See also==
*[[Vermiform appendix]].
*[[Granuloma]].
*[[Hypersensitivity]].
 
==References==
{{Reflist|1}}
 
[[Category:Diagnosis]]
[[Category:Vermiform appendix]]

Latest revision as of 21:16, 29 January 2016

Granulomatous appendicitis is an inflammatory process involving the vermiform appendix characterized by granulomas.

Interval appendectomy redirects to this article, as granulomas are often seen in that context.

General

Most common cause:

  • Yersinia appendicitis.[1]

DDx:[2]

  • Yersinia appendicitis.[1]
    • Yersinia = gram negative rod (red on Gram stain).
    • "Safety pin"-like appearance[3] - approximately 0.5 micrometers diameter x 2 micrometers length.
  • Other micro-organism (TB, fungus).
  • Crohn's disease.
  • Sarcoidosis.
  • Foreign body reaction.
  • Interval (delayed) appendectomy.
    • Approximately 60% of delayed appendectomies have granulomas.[4]

Microscopic

Features:

  • Granulomas.
  • +/-"Safety pin"-like organisms (Yersinia).

Image(s):

  • Granulomatous Appendicitis (SKB)

  • Suppurating Granulomatous Appendicitis (SKB)

  • Suppurating Granulomatous Yersinia Appendicitis (SKB)

  • Suppurating Granulomatous Yersinia Appendicitis Yersinia(SKB)

See also

References

  1. ↑ 1.0 1.1 Lamps LW, Madhusudhan KT, Greenson JK, et al. (April 2001). "The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study". Am. J. Surg. Pathol. 25 (4): 508–15. PMID 11257626.
  2. ↑ http://granuloma.homestead.com/appendicitis.html
  3. ↑ URL: http://www.cdc.gov/ncidod/dvbid/plague/p1.htm. Accessed on: 30 June 2011.
  4. ↑ Guo, G.; Greenson, JK. (Aug 2003). "Histopathology of interval (delayed) appendectomy specimens: strong association with granulomatous and xanthogranulomatous appendicitis.". Am J Surg Pathol 27 (8): 1147-51. PMID 12883248.
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