Difference between revisions of "Multifocal fibrosing thyroiditis"
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'''Multifocal fibrosing thyroiditis''' is a benign pathology of the [[thyroid]] that can mimic [[papillary thyroid carcinoma]]. | '''Multifocal fibrosing thyroiditis''', abbreviated '''MFT''', is a benign pathology of the [[thyroid]] that can mimic [[papillary thyroid carcinoma]]. | ||
It is also known as '''multifocal sclerosing thyroiditis'''.<ref name=pmid25353282>{{Cite journal | last1 = Fellegara | first1 = G. | last2 = Rosai | first2 = J. | title = Multifocal fibrosing thyroiditis: report of 55 cases of a poorly recognized entity. | journal = Am J Surg Pathol | volume = 39 | issue = 3 | pages = 416-24 | month = Mar | year = 2015 | doi = 10.1097/PAS.0000000000000337 | PMID = 25353282 }}</ref> | It is also known as '''multifocal sclerosing thyroiditis'''.<ref name=pmid25353282>{{Cite journal | last1 = Fellegara | first1 = G. | last2 = Rosai | first2 = J. | title = Multifocal fibrosing thyroiditis: report of 55 cases of a poorly recognized entity. | journal = Am J Surg Pathol | volume = 39 | issue = 3 | pages = 416-24 | month = Mar | year = 2015 | doi = 10.1097/PAS.0000000000000337 | PMID = 25353282 }}</ref> | ||
==General== | |||
*Uncommon - though may be under-recognized. | |||
*Female predominant in largest series (93% of cases versus 7% of cases).<ref name=pmid25353282/> | |||
==Microscopic== | |||
Features:<ref name=pmid25353282/> | |||
*Fibrotic foci - two foci required - '''key feature'''. | |||
**May be: (1) sharply demarcated from the surround parenchyma (stellate or triangular) or (2) band-like. | |||
Note: | |||
*MFT on average has 16 foci of fibrosis. These foci range in size from approximately 0.35 to 15 mm.<ref name=pmid25353282/> | |||
*Should '''not''' have have [[nuclear pseudoinclusion]]s or [[psammoma bodies]].<ref name=pmid25353282/> | |||
DDx:<ref name=pmid25353282/> | |||
*[[Hashimoto thyroiditis]]. | |||
*[[Adenomatoid hyperplasia of thyroid]]. | |||
*[[Papillary thyroid carcinoma]]. | |||
*[[Riedel thyroiditis]]. | |||
*Changes due to fine needle aspiration - should have hemosiderin, not multifocal. | |||
==See also== | ==See also== | ||
*[[Riedel thyroiditis]]. | *[[Riedel thyroiditis]]. | ||
*[[IgG4-related systemic diseases]]. | |||
==References== | ==References== | ||
Latest revision as of 15:41, 17 October 2017
Multifocal fibrosing thyroiditis, abbreviated MFT, is a benign pathology of the thyroid that can mimic papillary thyroid carcinoma.
It is also known as multifocal sclerosing thyroiditis.[1]
General
- Uncommon - though may be under-recognized.
- Female predominant in largest series (93% of cases versus 7% of cases).[1]
Microscopic
Features:[1]
- Fibrotic foci - two foci required - key feature.
- May be: (1) sharply demarcated from the surround parenchyma (stellate or triangular) or (2) band-like.
Note:
- MFT on average has 16 foci of fibrosis. These foci range in size from approximately 0.35 to 15 mm.[1]
- Should not have have nuclear pseudoinclusions or psammoma bodies.[1]
DDx:[1]
- Hashimoto thyroiditis.
- Adenomatoid hyperplasia of thyroid.
- Papillary thyroid carcinoma.
- Riedel thyroiditis.
- Changes due to fine needle aspiration - should have hemosiderin, not multifocal.