Difference between revisions of "Canalicular adenoma"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Canalicular_adenoma_--_high_mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Canalicular adenoma. [[H&E stain]]. (WC) | ||
| Synonyms = | | Synonyms = | ||
| Micro = cords of tumour ("canals") with beading (characteristic), cystic spaces/tubules, | | Micro = cords of tumour ("canals") with beading (characteristic), cystic spaces/tubules, | ||
| Line 17: | Line 17: | ||
| Grossing = | | Grossing = | ||
| Staging = | | Staging = | ||
| Site = [[salivary gland]] - usually upper lip | | Site = [[salivary gland]] - usually upper lip or buccal mucosa | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Line 54: | Line 54: | ||
*Cystic spaces/tubules. | *Cystic spaces/tubules. | ||
*Intraluminal squamous balls - common (~60% of cases). | *Intraluminal squamous balls - common (~60% of cases). | ||
*Myxoid/bluish stroma. | |||
DDx: | DDx: | ||
| Line 59: | Line 60: | ||
===Images=== | ===Images=== | ||
*[http://www. | <gallery> | ||
*[http://www. | Image: Canalicular adenoma -- intermed mag.jpg | CA - intermed. mag. (WC) | ||
Image: Canalicular adenoma - alt -- intermed mag.jpg | CA - intermed. mag. (WC) | |||
Image: Canalicular adenoma -- high mag.jpg | CA - high mag. (WC) | |||
Image: Canalicular adenoma -- very high mag.jpg | CA - very high mag. (WC) | |||
Image: Canalicular adenoma - alt -- very high mag.jpg | CA - very high mag. (WC) | |||
</gallery> | |||
====www==== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424207/figure/Fig2/ CA (nih.gov)].<ref name=pmid25141970/> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424207/figure/Fig3/ CA with myxoid stroma (nih.gov)]. | |||
==IHC== | ==IHC== | ||
*[[ | Features:<ref name=pmid25141970/> | ||
** | *[[S-100]] +ve - diffuse and strong. | ||
*[[Pankeratin]] +ve - diffuse and strong. | |||
*GFAP +ve - luminal. | |||
*SOX10 +ve - nuclear. | |||
*p16 +ve - luminal squamous balls. | |||
*CK5/6 +ve - luminal squamous balls. | |||
*p63 -ve. | |||
**Nuclei negative, cytoplasm positive. | |||
**Positive in basal cell adenoma. | |||
==See also== | ==See also== | ||
Latest revision as of 21:43, 1 August 2016
| Canalicular adenoma | |
|---|---|
| Diagnosis in short | |
 Canalicular adenoma. H&E stain. (WC) | |
|
| |
| LM |
cords of tumour ("canals") with beading (characteristic), cystic spaces/tubules, intraluminal squamous balls (common) |
| Site | salivary gland - usually upper lip or buccal mucosa |
|
| |
| Signs | mass lesion |
| Prevalence | very rare |
Canalicular adenoma is a rare salivary gland tumour.
General
- Exclusively oral cavity.
Clinical:
- Mass lesion.[1]
Gross
- Classically upper lip - may be buccal mucosa or palate.
Note:
- In one large series of 67 cases:[1]
- Upper lip 69% (47/67).
- Buccal mucosa 25% (17/67).
- Palate 6% (4/67).
Microscopic
Features:[1]
- Cords of tumour ("canals") with beading - characteristic.
- Cystic spaces/tubules.
- Intraluminal squamous balls - common (~60% of cases).
- Myxoid/bluish stroma.
DDx:
Images
CA - intermed. mag. (WC)
CA - intermed. mag. (WC)
CA - high mag. (WC)
CA - very high mag. (WC)
CA - very high mag. (WC)
www
IHC
Features:[1]
- S-100 +ve - diffuse and strong.
- Pankeratin +ve - diffuse and strong.
- GFAP +ve - luminal.
- SOX10 +ve - nuclear.
- p16 +ve - luminal squamous balls.
- CK5/6 +ve - luminal squamous balls.
- p63 -ve.
- Nuclei negative, cytoplasm positive.
- Positive in basal cell adenoma.
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Thompson, LD.; Bauer, JL.; Chiosea, S.; McHugh, JB.; Seethala, RR.; Miettinen, M.; Müller, S. (Jun 2015). "Canalicular adenoma: a clinicopathologic and immunohistochemical analysis of 67 cases with a review of the literature.". Head Neck Pathol 9 (2): 181-95. doi:10.1007/s12105-014-0560-6. PMID 25141970.