Difference between revisions of "Mucinous adenocarcinoma of the prostate"
Jump to navigation
Jump to search
(split out) |
|||
| (6 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Mucinous adenocarcinoma of prostate - 2b -- high mag.jpg | |||
| Width = | |||
| Caption = Mucinous adenocarcinoma of the prostate (left of image) with acinar adenocarcinoma of the prostate (right of image). [[H&E stain]]. (WC/Nephron) | |||
| Synonyms = | |||
| Micro = cytologically malignant (prostatic) cells floating in mucin; >25% of tumour mucinous | |||
| Subtypes = | |||
| LMDDx = acinar adenocarcinoma of the prostate with a minor mucinous component (<25%), metastatic [[mucinous carcinoma]], mucinous adenocarcinoma of the prostatic urethra | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = [[prostatectomy grossing]], [[TURP specimens]] | |||
| Staging = | |||
| Site = [[prostate gland]] - see ''[[prostate cancer]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = PSA elevated | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = dependent on grade | |||
| Other = | |||
| ClinDDx = | |||
| Tx = prostatectomy, radiation or observation | |||
}} | |||
'''Mucinous adenocarcinoma of the prostate''' is an uncommon type of [[prostate cancer]]. | '''Mucinous adenocarcinoma of the prostate''' is an uncommon type of [[prostate cancer]]. | ||
==General== | ==General== | ||
*Rare. | *Rare.<ref name=pmid18300802/> | ||
*Most often Gleason 3+4 ~ 80% in one series of 47 cases.<ref name=pmid18300802>{{Cite journal | last1 = Osunkoya | first1 = AO. | last2 = Nielsen | first2 = ME. | last3 = Epstein | first3 = JI. | title = Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: a study of 47 cases. | journal = Am J Surg Pathol | volume = 32 | issue = 3 | pages = 468-72 | month = Mar | year = 2008 | doi = 10.1097/PAS.0b013e3181589f72 | PMID = 18300802 }}</ref> | *Most often Gleason 3+4 ~ 80% in one series of 47 cases.<ref name=pmid18300802>{{Cite journal | last1 = Osunkoya | first1 = AO. | last2 = Nielsen | first2 = ME. | last3 = Epstein | first3 = JI. | title = Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: a study of 47 cases. | journal = Am J Surg Pathol | volume = 32 | issue = 3 | pages = 468-72 | month = Mar | year = 2008 | doi = 10.1097/PAS.0b013e3181589f72 | PMID = 18300802 }}</ref> | ||
| Line 21: | Line 53: | ||
*Metastatic [[mucinous carcinoma]]. | *Metastatic [[mucinous carcinoma]]. | ||
*Mucinous adenocarcinoma of the prostatic urethra - analogous to the mucinous adenocarcinoma of the [[urinary bladder]].<ref name=pmid23060063/> | *Mucinous adenocarcinoma of the prostatic urethra - analogous to the mucinous adenocarcinoma of the [[urinary bladder]].<ref name=pmid23060063/> | ||
===Images=== | |||
<gallery> | |||
Image: Mucinous adenocarcinoma of prostate -- low mag.jpg | MAP - low mag. (WC/Nephron) | |||
Image: Mucinous adenocarcinoma of prostate -- intermed mag.jpg | MAP - intermed. mag. (WC/Nephron) | |||
Image: Mucinous adenocarcinoma of prostate -- high mag.jpg | MAP - high mag. (WC/Nephron) | |||
Image: Mucinous adenocarcinoma of prostate -- very high mag.jpg | MAP - very high mag. (WC/Nephron) | |||
Image: Mucinous adenocarcinoma of prostate - alt -- low mag.jpg | MAP - low mag. (WC/Nephron) | |||
Image: Mucinous adenocarcinoma of prostate - 2 -- intermed mag.jpg | MAP - intermed. mag. (WC/Nephron) | |||
Image: Mucinous adenocarcinoma of prostate - 2a -- high mag.jpg | MAP - high mag. (WC/Nephron) | |||
Image: Mucinous adenocarcinoma of prostate - 2b -- high mag.jpg | MAP - high mag. (WC/Nephron) | |||
</gallery> | |||
==See also== | ==See also== | ||
Latest revision as of 03:18, 13 June 2016
| Mucinous adenocarcinoma of the prostate | |
|---|---|
| Diagnosis in short | |
 Mucinous adenocarcinoma of the prostate (left of image) with acinar adenocarcinoma of the prostate (right of image). H&E stain. (WC/Nephron) | |
|
| |
| LM | cytologically malignant (prostatic) cells floating in mucin; >25% of tumour mucinous |
| LM DDx | acinar adenocarcinoma of the prostate with a minor mucinous component (<25%), metastatic mucinous carcinoma, mucinous adenocarcinoma of the prostatic urethra |
| Grossing notes | prostatectomy grossing, TURP specimens |
| Site | prostate gland - see prostate cancer |
|
| |
| Prevalence | rare |
| Blood work | PSA elevated |
| Prognosis | dependent on grade |
| Treatment | prostatectomy, radiation or observation |
Mucinous adenocarcinoma of the prostate is an uncommon type of prostate cancer.
General
Gleason pattern:
- In the past, it has been suggested that the mucinous component be assigned Gleason pattern 4.[2]
- The prognosis is similar or may be better than the conventional type of prostate cancer in a large series;[1] thus, it seems reasonable to grade based on the pattern (as advocated by some experts[3]).
Microscopic
Features:
- Cytologically malignant cells floating in mucin.
- > 25% of tumour mucinous.[2]
Notes:
- Mucinous carcinoma - percentage required to call varies by site.
DDx:
- Metastatic mucinous carcinoma.
- Mucinous adenocarcinoma of the prostatic urethra - analogous to the mucinous adenocarcinoma of the urinary bladder.[5]
Images
MAP - low mag. (WC/Nephron)
MAP - intermed. mag. (WC/Nephron)
MAP - high mag. (WC/Nephron)
MAP - very high mag. (WC/Nephron)
MAP - low mag. (WC/Nephron)
MAP - intermed. mag. (WC/Nephron)
MAP - high mag. (WC/Nephron)
MAP - high mag. (WC/Nephron)
See also
References
- ↑ 1.0 1.1 1.2 Osunkoya, AO.; Nielsen, ME.; Epstein, JI. (Mar 2008). "Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: a study of 47 cases.". Am J Surg Pathol 32 (3): 468-72. doi:10.1097/PAS.0b013e3181589f72. PMID 18300802.
- ↑ 2.0 2.1 Grignon DJ (March 2004). "Unusual subtypes of prostate cancer". Mod. Pathol. 17 (3): 316–27. doi:10.1038/modpathol.3800052. PMID 14976541.
- ↑ Osunkoya, AO.; Adsay, NV.; Cohen, C.; Epstein, JI.; Smith, SL. (Jul 2008). "MUC2 expression in primary mucinous and nonmucinous adenocarcinoma of the prostate: an analysis of 50 cases on radical prostatectomy.". Mod Pathol 21 (7): 789-94. doi:10.1038/modpathol.2008.47. PMID 18487999.
- ↑ Osunkoya AO, Nielsen ME, Epstein JI (March 2008). "Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: a study of 47 cases". Am. J. Surg. Pathol. 32 (3): 468–72. doi:10.1097/PAS.0b013e3181589f72. PMID 18300802.
- ↑ 5.0 5.1 Bohman, KD.; Osunkoya, AO. (Nov 2012). "Mucin-producing tumors and tumor-like lesions involving the prostate: a comprehensive review.". Adv Anat Pathol 19 (6): 374-87. doi:10.1097/PAP.0b013e318271a361. PMID 23060063.