Difference between revisions of "Radiation esophagitis"
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'''Radiation esophagitis''' is a relatively uncommon pathology of the [[esophagus]] seen in the context of radiation treatments for thoracic malignancies. | '''Radiation esophagitis''' is a relatively uncommon pathology of the [[esophagus]], typically seen in the context of radiation treatments for thoracic [[cancer|malignancies]]. | ||
==General== | ==General== | ||
*Uncommon ~1% of patients getting radiation.<ref name=pmid26030254>{{Cite journal | last1 = Murro | first1 = D. | last2 = Jakate | first2 = S. | title = Radiation esophagitis. | journal = Arch Pathol Lab Med | volume = 139 | issue = 6 | pages = 827-30 | month = Jun | year = 2015 | doi = 10.5858/arpa.2014-0111-RS | PMID = 26030254 }}</ref> | *Uncommon ~1% of patients getting (thoracic) radiation.<ref name=pmid26030254>{{Cite journal | last1 = Murro | first1 = D. | last2 = Jakate | first2 = S. | title = Radiation esophagitis. | journal = Arch Pathol Lab Med | volume = 139 | issue = 6 | pages = 827-30 | month = Jun | year = 2015 | doi = 10.5858/arpa.2014-0111-RS | PMID = 26030254 }}</ref> | ||
==Gross/endoscopic== | |||
Features: | |||
*Erythema - nonspecific.<ref name=pmid26030254/> | |||
==Microscopic== | |||
Features:<ref name=pmid26030254/> | |||
*Variable inflammation. | |||
*Radiation-related [[nuclear atypia]] - endothelial cells and stromal cells. | |||
DDx: | |||
*[[Cytomegalovirus]]. | |||
==IHC== | |||
*[[CMV]] -ve. | |||
==Sign out== | ==Sign out== | ||
<pre> | <pre> | ||
Esophagus, 25 cm, Biopsy: | Esophagus, 25 cm, Biopsy: | ||
| Line 16: | Line 30: | ||
Stains are pending to exclude micro-organisms not appreciated on H&E staining; the results will be reported in an addendum. | Stains are pending to exclude micro-organisms not appreciated on H&E staining; the results will be reported in an addendum. | ||
</pre> | </pre> | ||
==See also== | |||
*[[Radiation changes]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Gastrointestinal pathology]] | [[Category:Gastrointestinal pathology]] | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
Latest revision as of 12:38, 15 April 2016
Radiation esophagitis is a relatively uncommon pathology of the esophagus, typically seen in the context of radiation treatments for thoracic malignancies.
General
- Uncommon ~1% of patients getting (thoracic) radiation.[1]
Gross/endoscopic
Features:
- Erythema - nonspecific.[1]
Microscopic
Features:[1]
- Variable inflammation.
- Radiation-related nuclear atypia - endothelial cells and stromal cells.
DDx:
IHC
- CMV -ve.
Sign out
Esophagus, 25 cm, Biopsy: - Acute esophagitis with edema, see comment. - NEGATIVE for dysplasia and NEGATIVE for malignancy. Comment: The history of radiation is noted. Stains are pending to exclude micro-organisms not appreciated on H&E staining; the results will be reported in an addendum.