Difference between revisions of "Oncocytoma of the salivary gland"
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| Prevalence = very rare | | Prevalence = very rare | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = blends with normal salivary gland on T1 postcontrast and fat-saturated T2 MR images | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = benign | | Prognosis = benign | ||
| Line 40: | Line 40: | ||
*Associated with radiation exposure. | *Associated with radiation exposure. | ||
*Major salivary glands - usually parotid gland.<ref name=pmid19796983>{{Cite journal | last1 = Zhou | first1 = CX. | last2 = Gao | first2 = Y. | title = Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. | journal = Oral Oncol | volume = 45 | issue = 12 | pages = e232-8 | month = Dec | year = 2009 | doi = 10.1016/j.oraloncology.2009.08.004 | PMID = 19796983 }}</ref> | *Major salivary glands - usually parotid gland.<ref name=pmid19796983>{{Cite journal | last1 = Zhou | first1 = CX. | last2 = Gao | first2 = Y. | title = Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. | journal = Oral Oncol | volume = 45 | issue = 12 | pages = e232-8 | month = Dec | year = 2009 | doi = 10.1016/j.oraloncology.2009.08.004 | PMID = 19796983 }}</ref> | ||
*Case report of oncocytoma of parotid as manifestation of [[Birt-Hogg-Dubé syndrome]].<ref name=pmid29971177>{{cite journal |authors=Yoshida K, Miyagawa M, Kido T, Ide K, Sano Y, Sugawara Y, Takahata H, Monden N, Furuya M, Mochizuki T |title=Parotid Oncocytoma as a Manifestation of Birt-Hogg-Dubé Syndrome |journal=Case Rep Radiol |volume=2018 |issue= |pages=6265175 |date=2018 |pmid=29971177 |pmc=6008813 |doi=10.1155/2018/6265175 |url=}}</ref> | |||
==Gross== | ==Gross== | ||
*Golden brown appearance. | *Golden brown appearance. | ||
Note: | |||
*"Disappear" into background salivary gland on MRI: isointense to normal on fat-saturated T2 and T1 postcontrast images.<ref name=pmid21757520>{{Cite journal | last1 = Patel | first1 = ND. | last2 = van Zante | first2 = A. | last3 = Eisele | first3 = DW. | last4 = Harnsberger | first4 = HR. | last5 = Glastonbury | first5 = CM. | title = Oncocytoma: the vanishing parotid mass. | journal = AJNR Am J Neuroradiol | volume = 32 | issue = 9 | pages = 1703-6 | month = Oct | year = 2011 | doi = 10.3174/ajnr.A2569 | PMID = 21757520 }}</ref> | |||
===Image=== | ===Image=== | ||
<gallery> | <gallery> | ||
| Line 61: | Line 64: | ||
DDx: | DDx: | ||
*[[Warthin tumour]] - have lymphocytes, classical bilayer. | |||
*[[Acinic cell carcinoma]]. | *[[Acinic cell carcinoma]]. | ||
*Metastatic [[renal cell carcinoma]] - esp. [[chromophobe renal cell carcinoma]]. | *Metastatic [[renal cell carcinoma]] - esp. [[chromophobe renal cell carcinoma]]. | ||
| Line 78: | Line 82: | ||
*p63 +ve<ref name=pmid20614263>{{Cite journal | last1 = McHugh | first1 = JB. | last2 = Hoschar | first2 = AP. | last3 = Dvorakova | first3 = M. | last4 = Parwani | first4 = AV. | last5 = Barnes | first5 = EL. | last6 = Seethala | first6 = RR. | title = p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. | journal = Head Neck Pathol | volume = 1 | issue = 2 | pages = 123-31 | month = Dec | year = 2007 | doi = 10.1007/s12105-007-0031-4 | PMID = 20614263 | PMC = 2807526}}</ref> focally in nucleus. | *p63 +ve<ref name=pmid20614263>{{Cite journal | last1 = McHugh | first1 = JB. | last2 = Hoschar | first2 = AP. | last3 = Dvorakova | first3 = M. | last4 = Parwani | first4 = AV. | last5 = Barnes | first5 = EL. | last6 = Seethala | first6 = RR. | title = p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. | journal = Head Neck Pathol | volume = 1 | issue = 2 | pages = 123-31 | month = Dec | year = 2007 | doi = 10.1007/s12105-007-0031-4 | PMID = 20614263 | PMC = 2807526}}</ref> focally in nucleus. | ||
*DOG1 -ve.<ref name=pmid26425134>{{Cite journal | last1 = Canberk | first1 = S. | last2 = Onenerk | first2 = M. | last3 = Sayman | first3 = E. | last4 = Goret | first4 = CC. | last5 = Erkan | first5 = M. | last6 = Atasoy | first6 = T. | last7 = Kilicoglu | first7 = GZ. | title = Is DOG1 really useful in the diagnosis of salivary gland acinic cell carcinoma? - A DOG1 (clone K9) analysis in fine needle aspiration cell blocks and the review of the literature. | journal = Cytojournal | volume = 12 | issue = | pages = 18 | month = | year = 2015 | doi = 10.4103/1742-6413.162774 | PMID = 26425134 }}</ref> | *DOG1 -ve.<ref name=pmid26425134>{{Cite journal | last1 = Canberk | first1 = S. | last2 = Onenerk | first2 = M. | last3 = Sayman | first3 = E. | last4 = Goret | first4 = CC. | last5 = Erkan | first5 = M. | last6 = Atasoy | first6 = T. | last7 = Kilicoglu | first7 = GZ. | title = Is DOG1 really useful in the diagnosis of salivary gland acinic cell carcinoma? - A DOG1 (clone K9) analysis in fine needle aspiration cell blocks and the review of the literature. | journal = Cytojournal | volume = 12 | issue = | pages = 18 | month = | year = 2015 | doi = 10.4103/1742-6413.162774 | PMID = 26425134 }}</ref> | ||
*PAX8 -ve.<ref name=pmid24771139>{{cite journal |authors=Butler RT, Alderman MA, Thompson LD, McHugh JB |title=Evaluation of PAX2 and PAX8 expression in salivary gland neoplasms |journal=Head Neck Pathol |volume=9 |issue=1 |pages=47–50 |date=March 2015 |pmid=24771139 |pmc=4382472 |doi=10.1007/s12105-014-0546-4 |url=}}</ref> | |||
==EM== | ==EM== | ||
*Increased numbers of mitochondria. | *Increased numbers of mitochondria. | ||
==Sign out== | |||
<pre> | |||
Nodule, Right Parotid Gland, Core Biopsy: | |||
- ONCOCYTOMA. | |||
Comment: | |||
The tumour stains as follows: | |||
POSITIVE: p63 (focal, nuclear). | |||
NEGATIVE: CD10, RCC, S-100, CD68, vimentin. | |||
</pre> | |||
===Micro=== | |||
The sections show cells with abundant eosinophilic cytoplasm and bland round nuclei in a tubular architecture. Mitotic activity is not readily apparent. Significant nuclear atypia is absent. | |||
==See also== | ==See also== | ||
Latest revision as of 17:23, 25 March 2021
| Oncocytoma of the salivary gland | |
|---|---|
| Diagnosis in short | |
 Salivary gland oncocytoma. H&E stain. (WC/Nephron) | |
|
| |
| Synonyms | salivary gland oncocytoma |
|
| |
| LM | abundant eosinophilic cytoplasm; architecture: solid, trabecular or duct-like |
| LM DDx | acinic cell carcinoma, metastatic renal cell carcinoma, oncocytic carcinoma, granular cell tumour |
| IHC | p63 +ve |
| EM | increased numbers of mitochondria |
| Site | salivary gland |
|
| |
| Prevalence | very rare |
| Radiology | blends with normal salivary gland on T1 postcontrast and fat-saturated T2 MR images |
| Prognosis | benign |
| Clin. DDx | other salivary gland tumours |
Oncocytoma of the salivary gland (also salivary gland oncocytoma) is a rare benign tumour of the salivary glands.
General
- No risk of malignant transformation.
- Rare ~20 reported in literature.[1]
- Thought to be ~1% of all salivary gland tumours.
- Typical age: 60s-80s.
- Associated with radiation exposure.
- Major salivary glands - usually parotid gland.[2]
- Case report of oncocytoma of parotid as manifestation of Birt-Hogg-Dubé syndrome.[3]
Gross
- Golden brown appearance.
Note:
- "Disappear" into background salivary gland on MRI: isointense to normal on fat-saturated T2 and T1 postcontrast images.[4]
Image
Salivary gland oncocytoma (WC/euthman)
Microscopic
Features:
- Like oncocytomas elsewhere.
- Abundant eosinophilic cytoplasm (on H&E stain).
- Due to increased number of mitochrondria.
- Fine capillaries.
- Abundant eosinophilic cytoplasm (on H&E stain).
- Architecture: solid sheets, trabeculae or duct-like structure.[2]
Notes:
- May have clear cell change.
- Multiple small incidental lesions = oncocytosis - not oncocytoma.
DDx:
- Warthin tumour - have lymphocytes, classical bilayer.
- Acinic cell carcinoma.
- Metastatic renal cell carcinoma - esp. chromophobe renal cell carcinoma.
- Oncocytic carcinoma.
- Granular cell tumour.
Images
www:
Parotid gland oncocytoma - intermed. mag. (WC/Nephron)
Parotid gland oncocytoma - high mag. (WC/Nephron)
Parotid gland oncocytoma - very high mag. (WC/Nephron)
IHC
EM
- Increased numbers of mitochondria.
Sign out
Nodule, Right Parotid Gland, Core Biopsy: - ONCOCYTOMA. Comment: The tumour stains as follows: POSITIVE: p63 (focal, nuclear). NEGATIVE: CD10, RCC, S-100, CD68, vimentin.
Micro
The sections show cells with abundant eosinophilic cytoplasm and bland round nuclei in a tubular architecture. Mitotic activity is not readily apparent. Significant nuclear atypia is absent.
See also
References
- ↑ Uzunkulaoğlu H, Yazici H, Can IH, Doğan S, Uzunkulaoğlu T (May 2012). "Bilateral oncocytoma in the parotid gland". J Craniofac Surg 23 (3): e246–7. doi:10.1097/SCS.0b013e31824dfccd. PMID 22627459.
- ↑ 2.0 2.1 Zhou, CX.; Gao, Y. (Dec 2009). "Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study.". Oral Oncol 45 (12): e232-8. doi:10.1016/j.oraloncology.2009.08.004. PMID 19796983.
- ↑ Yoshida K, Miyagawa M, Kido T, Ide K, Sano Y, Sugawara Y, Takahata H, Monden N, Furuya M, Mochizuki T (2018). "Parotid Oncocytoma as a Manifestation of Birt-Hogg-Dubé Syndrome". Case Rep Radiol 2018: 6265175. doi:10.1155/2018/6265175. PMC 6008813. PMID 29971177. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008813/.
- ↑ Patel, ND.; van Zante, A.; Eisele, DW.; Harnsberger, HR.; Glastonbury, CM. (Oct 2011). "Oncocytoma: the vanishing parotid mass.". AJNR Am J Neuroradiol 32 (9): 1703-6. doi:10.3174/ajnr.A2569. PMID 21757520.
- ↑ 5.0 5.1 McHugh, JB.; Hoschar, AP.; Dvorakova, M.; Parwani, AV.; Barnes, EL.; Seethala, RR. (Dec 2007). "p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma.". Head Neck Pathol 1 (2): 123-31. doi:10.1007/s12105-007-0031-4. PMC 2807526. PMID 20614263. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807526/.
- ↑ Canberk, S.; Onenerk, M.; Sayman, E.; Goret, CC.; Erkan, M.; Atasoy, T.; Kilicoglu, GZ. (2015). "Is DOG1 really useful in the diagnosis of salivary gland acinic cell carcinoma? - A DOG1 (clone K9) analysis in fine needle aspiration cell blocks and the review of the literature.". Cytojournal 12: 18. doi:10.4103/1742-6413.162774. PMID 26425134.
- ↑ Butler RT, Alderman MA, Thompson LD, McHugh JB (March 2015). "Evaluation of PAX2 and PAX8 expression in salivary gland neoplasms". Head Neck Pathol 9 (1): 47–50. doi:10.1007/s12105-014-0546-4. PMC 4382472. PMID 24771139. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382472/.