Difference between revisions of "Medial calcific sclerosis"
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| Micro = calcifications of the tunica media | | Micro = calcifications of the tunica media | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[atherosclerosis]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
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| Grossing = | | Grossing = | ||
| Staging = | | Staging = | ||
| Site = | | Site = [[blood vessels]] - arteries | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
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==General== | ==General== | ||
*Usually of no clinical consequence. | *Usually of no clinical consequence. | ||
*May impact vascular assessments using ultrasound.<ref>{{cite journal |authors=Suludere MA, Danesh SK, Killeen AL, Crisologo PA, Malone M, Siah MC, Lavery LA |title=Mönckeberg's Medial Calcific Sclerosis Makes Traditional Arterial Doppler's Unreliable in High-Risk Patients with Diabetes |journal=Int J Low Extrem Wounds |volume= |issue= |pages=15347346231191588 |date=July 2023 |pmid=37525549 |doi=10.1177/15347346231191588 |url=}}</ref> | |||
==Microscopic== | ==Microscopic== | ||
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Note: | Note: | ||
*Lumen unaffected. | *Lumen unaffected. | ||
*It has been suggested that it usually involves the ''internal elastic lamina''.<ref>{{cite journal |authors=Micheletti RG, Fishbein GA, Currier JS, Fishbein MC |title=Mönckeberg sclerosis revisited: a clarification of the histologic definition of Mönckeberg sclerosis |journal=Arch Pathol Lab Med |volume=132 |issue=1 |pages=43–7 |date=January 2008 |pmid=18181672 |doi=10.5858/2008-132-43-MSRACO |url=}}</ref> | |||
DDx:<ref>{{cite journal |authors=Dos Santos VP, Pozzan G, Castelli V, Caffaro RA |title=Arteriosclerosis, atherosclerosis, arteriolosclerosis, and Monckeberg medial calcific sclerosis: what is the difference? |journal=J Vasc Bras |volume=20 |issue= |pages=e20200211 |date=2021 |pmid=34290756 |pmc=8276643 |doi=10.1590/1677-5449.200211 |url=}}</ref> | |||
*[[Atherosclerosis]] (severe) - intimal hyperplasia with stenosis, calcifications typically in tunica intima. | |||
===Images=== | ===Images=== | ||
<gallery> | |||
Image: Medial calcific sclerosis -- low mag.jpg | MCS - low mag. (WC) | |||
Image: Medial calcific sclerosis -- intermed mag.jpg | MCS - intermed. mag. (WC) | |||
Image: Medial calcific sclerosis -- high mag.jpg | MCS - high mag. (WC) | |||
Image: Medial calcific sclerosis - alt -- intermed mag.jpg | MCS - intermed. mag. (WC) | |||
Image: Medial calcific sclerosis - alt -- high mag.jpg | MCS - high mag. (WC) | |||
</gallery> | |||
<gallery> | <gallery> | ||
Image:Calcificatio_atherosclerotica.jpg | MCS. (WC) | Image:Calcificatio_atherosclerotica.jpg | MCS. (WC) | ||
</gallery> | </gallery> | ||
==Sign out== | ==Sign out== | ||
| Line 62: | Line 73: | ||
The sections may not be representative of disease in the distal vascular bed. | The sections may not be representative of disease in the distal vascular bed. | ||
</pre> | </pre> | ||
==See also== | ==See also== | ||
Latest revision as of 20:49, 30 April 2025
| Medial calcific sclerosis | |
|---|---|
| Diagnosis in short | |
 Medial calcific sclerosis. H&E stain. | |
|
| |
| Synonyms | Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, Mönckeberg's arteriosclerosis (also written Monckeberg's arteriosclerosis) |
|
| |
| LM | calcifications of the tunica media |
| LM DDx | atherosclerosis |
| Site | blood vessels - arteries |
|
| |
| Prognosis | good |
| Treatment | (nothing) |
Medial calcific sclerosis is a type of arteriosclerosis that has no significant clinical impact.
It is also known as Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, and Mönckeberg's arteriosclerosis (also written Monckeberg's arteriosclerosis).
General
- Usually of no clinical consequence.
- May impact vascular assessments using ultrasound.[1]
Microscopic
Features:[2]
- Medial calcification (purple irregular stuff on H&E -- calcium phosphate).
Note:
- Lumen unaffected.
- It has been suggested that it usually involves the internal elastic lamina.[3]
DDx:[4]
- Atherosclerosis (severe) - intimal hyperplasia with stenosis, calcifications typically in tunica intima.
Images
MCS - low mag. (WC)
MCS - intermed. mag. (WC)
MCS - high mag. (WC)
MCS - intermed. mag. (WC)
MCS - high mag. (WC)
MCS. (WC)
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RIGHT LEG, BELOW KNEE AMPUTATION: - MINIMAL-TO-MILD LARGE VESSEL ATHEROSCLEROSIS, SEE COMMENT. - MEDIAL CALCIFIC SCLEROSIS. - SKIN WITH DERMAL FIBROSIS. COMMENT: The sections may not be representative of disease in the distal vascular bed.
See also
References
- ↑ Suludere MA, Danesh SK, Killeen AL, Crisologo PA, Malone M, Siah MC, Lavery LA (July 2023). "Mönckeberg's Medial Calcific Sclerosis Makes Traditional Arterial Doppler's Unreliable in High-Risk Patients with Diabetes". Int J Low Extrem Wounds: 15347346231191588. doi:10.1177/15347346231191588. PMID 37525549.
- ↑ Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 7. ISBN 978-1416002741.
- ↑ Micheletti RG, Fishbein GA, Currier JS, Fishbein MC (January 2008). "Mönckeberg sclerosis revisited: a clarification of the histologic definition of Mönckeberg sclerosis". Arch Pathol Lab Med 132 (1): 43–7. doi:10.5858/2008-132-43-MSRACO. PMID 18181672.
- ↑ Dos Santos VP, Pozzan G, Castelli V, Caffaro RA (2021). "Arteriosclerosis, atherosclerosis, arteriolosclerosis, and Monckeberg medial calcific sclerosis: what is the difference?". J Vasc Bras 20: e20200211. doi:10.1590/1677-5449.200211. PMC 8276643. PMID 34290756. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276643/.