Difference between revisions of "Post-transplant lymphoproliferative disorder"

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'''Post-transplant lymphoproliferative disorder''', vbbreviated ''PTLD'', is something afflicts people that had transplants (solid organ and bone marrow).  It is essentially a type of B-cell [[lymphoma]].
'''Post-transplant lymphoproliferative disorder''', abbreviated ''PTLD'', is something afflicts people that had transplants (solid organ and bone marrow).  It is essentially a type of B-cell [[lymphoma]].


==General==
==General==
*Rare.
*Rare.
*B cell neoplasm associated with EBV.<ref>URL: [http://emedicine.medscape.com/article/431364-overview http://emedicine.medscape.com/article/431364-overview]. Accessed on: 10 February 2011.</ref><ref name=pmid15660500>{{cite journal |author=Gottschalk S, Rooney CM, Heslop HE |title=Post-transplant lymphoproliferative disorders |journal=Annu. Rev. Med. |volume=56 |issue= |pages=29–44 |year=2005 |pmid=15660500 |doi=10.1146/annurev.med.56.082103.104727 |url=}}</ref>
*B cell neoplasm associated with [[EBV]].<ref>URL: [http://emedicine.medscape.com/article/431364-overview http://emedicine.medscape.com/article/431364-overview]. Accessed on: 10 February 2011.</ref><ref name=pmid15660500>{{cite journal |author=Gottschalk S, Rooney CM, Heslop HE |title=Post-transplant lymphoproliferative disorders |journal=Annu. Rev. Med. |volume=56 |issue= |pages=29–44 |year=2005 |pmid=15660500 |doi=10.1146/annurev.med.56.082103.104727 |url=}}</ref>
**Develop from a latent EBV infection - which may be detectable by the presence of "passenger cells" = scattered EBER positive lymphocytes.<ref>URL: [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1422031/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1422031/]. Accessed on: 3 March 2011.</ref>
**May develop from a clinically latent EBV infection that is detectable by the presence of "passenger cells" = scattered EBER positive lymphocytes.<ref>URL: [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1422031/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1422031/]. Accessed on: 3 March 2011.</ref>
*Commonly in the GI tract as it gets the most immunosuppression; immunosuppressives are taken orally -- not cleaned by the [[liver]] prior to reaching the GI tract.
*Commonly in the GI tract as it gets the most immunosuppression; immunosuppressives are taken orally -- not cleaned by the [[liver]] prior to reaching the GI tract.


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**Large lymphoid cells with a diameter ~2x a resting lymphocyte.
**Large lymphoid cells with a diameter ~2x a resting lymphocyte.
**Nucleoli.
**Nucleoli.
DDx:
*[[Diffuse large B cell lymphoma]].


==IHC==
==IHC==
*B cell markers +ve
*B cell markers +ve.
*EBER +ve -- diffuse.
*[[EBER]] diffusely +ve.


==See also==
==See also==
*[[Diffuse large B cell lymphoma]] (DLBCL).
*[[Heart transplant pathology]].
*[[Heart transplant pathology]].
*[[Lung transplant pathology]].
*[[Lung transplant pathology]].
*[[Lymphoproliferative disorder]].


==References==
==References==
{{Reflist|1}}
{{Reflist|2}}


[[Category:Haematopathology]]
[[Category:Haematopathology]]
[[Category:Diagnosis]]

Latest revision as of 19:56, 26 December 2019

Post-transplant lymphoproliferative disorder, abbreviated PTLD, is something afflicts people that had transplants (solid organ and bone marrow). It is essentially a type of B-cell lymphoma.

General

  • Rare.
  • B cell neoplasm associated with EBV.[1][2]
    • May develop from a clinically latent EBV infection that is detectable by the presence of "passenger cells" = scattered EBER positive lymphocytes.[3]
  • Commonly in the GI tract as it gets the most immunosuppression; immunosuppressives are taken orally -- not cleaned by the liver prior to reaching the GI tract.

Microscopic

Features:

  • Similar to large cell lymphomas:
    • Large lymphoid cells with a diameter ~2x a resting lymphocyte.
    • Nucleoli.

DDx:

IHC

  • B cell markers +ve.
  • EBER diffusely +ve.

See also

References

  1. ↑ URL: http://emedicine.medscape.com/article/431364-overview. Accessed on: 10 February 2011.
  2. ↑ Gottschalk S, Rooney CM, Heslop HE (2005). "Post-transplant lymphoproliferative disorders". Annu. Rev. Med. 56: 29–44. doi:10.1146/annurev.med.56.082103.104727. PMID 15660500.
  3. ↑ URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1422031/. Accessed on: 3 March 2011.
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