Difference between revisions of "Retinoblastoma"
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'''Retinoblastoma''' is malignant tumour the of the [[eye]]. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Rtbl400.GIF | |||
| Width = | |||
| Caption = Retinoblastoma. (WC) | |||
| Synonyms = | |||
| Micro = [[small round cell tumour]], Flexner-Wintersteiner [[rosette]]s, +/-Homer-Wright rosettes, mitoses (common), +/-necrosis, +/-calcifications | |||
| Subtypes = | |||
| LMDDx = retinocytoma, other [[small round cell tumours]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = white, solid, friable | |||
| Grossing = | |||
| Staging = | |||
| Site = [[eye]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Retinoblastoma''' is a malignant tumour the of the [[eye]]. | |||
==General== | ==General== | ||
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===Images=== | ===Images=== | ||
<gallery> | |||
Image:Rtbl400.GIF | Retinoblastoma. (WC) | |||
</gallery> | |||
====www==== | ====www==== | ||
*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/O0A001-PQ01-M.htm Retinoblastoma (ouhsc.edu)]. | *[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/O0A001-PQ01-M.htm Retinoblastoma (ouhsc.edu)]. | ||
Latest revision as of 03:55, 9 February 2016
| Retinoblastoma | |
|---|---|
| Diagnosis in short | |
 Retinoblastoma. (WC) | |
|
| |
| LM | small round cell tumour, Flexner-Wintersteiner rosettes, +/-Homer-Wright rosettes, mitoses (common), +/-necrosis, +/-calcifications |
| LM DDx | retinocytoma, other small round cell tumours |
| Gross | white, solid, friable |
| Site | eye |
|
| |
| Prevalence | rare |
Retinoblastoma is a malignant tumour the of the eye.
General
Gross
- White, solid.
- Patterns:
- Endophytic - grow into the vitreous cavity.
- Exophytic - grow toward choroid.
- Mixed - components of endophytic and exophytic.
Note:
- Tumour is extremely friable.
Image
Microscopic
Features:
- Small round cell tumour:
- Scant cytoplasm.
- Flexner-Wintersteiner rosette - key feature.
- Rosette with empty centre (donut hole).[2]
- +/-Homer-Wright rosette.[3]
- Circular rosette with neuropil at the centre.[2]
- Mitoses - common.
- +/-Necrosis.
- +/-Calcification.
DDx:
- Retinocytoma (retinoma) - benign counterpart of retinoblastoma.
Notes:
- DDx of Flexner-Wintersteiner rosette includes:
- Pineoblastoma.
- Medulloepithelioma.
Images
Retinoblastoma. (WC)