Difference between revisions of "Small cell carcinoma of the prostate gland"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Prostate carcinoma with NEC -- high mag.jpg | |||
| Width = | |||
| Caption = Small cell carcinoma of the prostate. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = small cells with nuclear moulding, stippled chromatin and high [[NC ratio]], +/-high-grade acinar adenocarcinoma (common) | |||
| Subtypes = | |||
| LMDDx = [[small cell carcinoma of the urinary bladder]], metastatic [[small cell carcinoma]], poorly differentiated [[prostate carcinoma]] | |||
| Stains = | |||
| IHC = chromogranin A +ve, PSA -ve/+ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = [[prostate biopsy]], [[prostate chips]], [[radical prostatectomy]] | |||
| Staging = [[prostate cancer staging]] | |||
| Site = [[prostate gland]] - see ''[[prostate cancer]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = [[PSA]] low (in relation to conventional cancer) | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = other types of [[prostate cancer]], metastatic cancer | |||
| Tx = chemotherapy | |||
}} | |||
'''Small cell carcinoma of the prostate gland''' is a rare type of [[prostate cancer]] with an aggressive course. | '''Small cell carcinoma of the prostate gland''' is a rare type of [[prostate cancer]] with an aggressive course. | ||
The more general topic of ''[[prostate cancer with neuroendocrine differentiation]]'' is dealt with in a separate article. | |||
==General== | ==General== | ||
| Line 5: | Line 39: | ||
*Most common small cell carcinoma outside of the lung.<ref name=pmid22110988/> | *Most common small cell carcinoma outside of the lung.<ref name=pmid22110988/> | ||
*Poor prognosis. | *Poor prognosis. | ||
*Not graded (ISUP 2005 consensus on [[Gleason | *Not [[prostate cancer grading|graded]] ([[ISUP]] 2005 consensus on [[Gleason grading system]]<ref name=pmid16096414>{{Cite journal | last1 = Epstein | first1 = JI. | last2 = Allsbrook | first2 = WC. | last3 = Amin | first3 = MB. | last4 = Egevad | first4 = LL. | title = The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. | journal = Am J Surg Pathol | volume = 29 | issue = 9 | pages = 1228-42 | month = Sep | year = 2005 | doi = | PMID = 16096414 }}</ref>). | ||
Clinical: | |||
*PSA often low in comparison to conventional prostate cancer.<ref name=pmid22110988/> | |||
==Microscopic== | ==Microscopic== | ||
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*[[Small cell carcinoma of the urinary bladder]]. | *[[Small cell carcinoma of the urinary bladder]]. | ||
*[[Lymphoma]], large cell. | *[[Lymphoma]], large cell. | ||
*[[Prostate carcinoma with amphicrine features]] - also have [[AR]] staining.<ref name=pmid28756619>{{Cite journal | last1 = Prendeville | first1 = S. | last2 = Al-Bozom | first2 = I. | last3 = Compérat | first3 = E. | last4 = Sweet | first4 = J. | last5 = Evans | first5 = AJ. | last6 = Ben-Gashir | first6 = M. | last7 = Mete | first7 = O. | last8 = van der Kwast | first8 = TH. | last9 = Downes | first9 = MR. | title = Prostate carcinoma with amphicrine features: further refining the spectrum of neuroendocrine differentiation in tumours of primary prostatic origin? | journal = Histopathology | volume = 71 | issue = 6 | pages = 926-933 | month = Dec | year = 2017 | doi = 10.1111/his.13330 | PMID = 28756619 }}</ref> | |||
*Other [[small round cell tumours]]. | *Other [[small round cell tumours]]. | ||
===Images=== | ===Images=== | ||
====Case==== | |||
<gallery> | |||
Image: Prostate carcinoma with NEC -- very low mag.jpg | PCNEC - very low mag. (WC) | |||
Image: Prostate carcinoma with NEC -- low mag.jpg | PCNEC - low mag. (WC) | |||
Image: Prostate carcinoma with NEC -- intermed mag.jpg | PCNEC - intermed. mag. (WC) | |||
Image: Prostate carcinoma with NEC -- high mag.jpg | PCNEC - high mag. (WC) | |||
Image: Prostate carcinoma with NEC - conv only -- low mag.jpg | PCNEC - low mag. (WC) | |||
Image: Prostate carcinoma with NEC - conv only -- intermed mag.jpg | PCNEC - intermed. mag. (WC) | |||
Image: Prostate carcinoma with NEC - conv only -- high mag.jpg | PCNEC - high mag. (WC) | |||
</gallery> | |||
====www==== | ====www==== | ||
*[http://www.webpathology.com/image.asp?case=23&n=25 SmCC of the prostate - low mag. (webpathology.com)]. | *[http://www.webpathology.com/image.asp?case=23&n=25 SmCC of the prostate - low mag. (webpathology.com)]. | ||
| Line 39: | Line 88: | ||
==See also== | ==See also== | ||
*[[Prostate cancer]]. | *[[Prostate cancer]]. | ||
*[[Small cell carcinoma]]. | |||
*[[Paneth cell-like change of the prostate gland]]. | |||
==References== | ==References== | ||
Latest revision as of 16:33, 19 March 2018
| Small cell carcinoma of the prostate gland | |
|---|---|
| Diagnosis in short | |
 Small cell carcinoma of the prostate. H&E stain. | |
|
| |
| LM | small cells with nuclear moulding, stippled chromatin and high NC ratio, +/-high-grade acinar adenocarcinoma (common) |
| LM DDx | small cell carcinoma of the urinary bladder, metastatic small cell carcinoma, poorly differentiated prostate carcinoma |
| IHC | chromogranin A +ve, PSA -ve/+ve |
| Grossing notes | prostate biopsy, prostate chips, radical prostatectomy |
| Staging | prostate cancer staging |
| Site | prostate gland - see prostate cancer |
|
| |
| Prevalence | rare |
| Blood work | PSA low (in relation to conventional cancer) |
| Prognosis | poor |
| Clin. DDx | other types of prostate cancer, metastatic cancer |
| Treatment | chemotherapy |
Small cell carcinoma of the prostate gland is a rare type of prostate cancer with an aggressive course.
The more general topic of prostate cancer with neuroendocrine differentiation is dealt with in a separate article.
General
- Very rare.[1]
- Most common small cell carcinoma outside of the lung.[1]
- Poor prognosis.
- Not graded (ISUP 2005 consensus on Gleason grading system[2]).
Clinical:
- PSA often low in comparison to conventional prostate cancer.[1]
Microscopic
Features:
- Small cells with:
- Nuclear moulding.
- Stippled chromatin.
- High NC ratio.
- +/-High-grade acinar adenocarcinoma, i.e. conventional prostate carcinoma, seen in ~50% of cases.[1]
Notes:
- Similar to small cell carcinoma of the lung.
- High-grade squamoid component favours metastatic urothelial carcinoma.
- UCC usu. HWCK +ve.
DDx:
- Small cell carcinoma of the urinary bladder.
- Lymphoma, large cell.
- Prostate carcinoma with amphicrine features - also have AR staining.[3]
- Other small round cell tumours.
Images
Case
PCNEC - very low mag. (WC)
PCNEC - low mag. (WC)
PCNEC - intermed. mag. (WC)
PCNEC - high mag. (WC)
PCNEC - low mag. (WC)
PCNEC - intermed. mag. (WC)
PCNEC - high mag. (WC)
www
- SmCC of the prostate - low mag. (webpathology.com).
- SmCC of the prostate - high mag. (webpathology.com).
- SmCC of the prostate - low mag. (nih.gov).
- SmCC of the prostate - high mag. (nih.gov).
IHC
Features:[1]
- PSA weak +ve/-ve.
- Chromogranin +ve.
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Furtado, P.; Lima, MV.; Nogueira, C.; Franco, M.; Tavora, F. (2011). "Review of small cell carcinomas of the prostate.". Prostate Cancer 2011: 543272. doi:10.1155/2011/543272. PMID 22110988.
- ↑ Epstein, JI.; Allsbrook, WC.; Amin, MB.; Egevad, LL. (Sep 2005). "The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma.". Am J Surg Pathol 29 (9): 1228-42. PMID 16096414.
- ↑ Prendeville, S.; Al-Bozom, I.; Compérat, E.; Sweet, J.; Evans, AJ.; Ben-Gashir, M.; Mete, O.; van der Kwast, TH. et al. (Dec 2017). "Prostate carcinoma with amphicrine features: further refining the spectrum of neuroendocrine differentiation in tumours of primary prostatic origin?". Histopathology 71 (6): 926-933. doi:10.1111/his.13330. PMID 28756619.