Difference between revisions of "Case 85"
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Very low magnification. H&E stain.
(Created page with "===Provided clinical history=== 78 year old man ===Site=== Right epididymis - mass ===Primary image=== Image: Papillary cystadenoma of epididymis -- very low mag.jpg |500p...") |
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===Additional tests=== | ===Additional tests=== | ||
====More history==== | ====More history==== | ||
{{hidden|More history|<center> | {{hidden|More history|<center>Paratesticular mass (unilateral) on testicular US. Patient feels well. No history of malignancy. Abdominal US is negative. Patient has hypercholesterolemia and high blood pressure.</center>}} | ||
====Ask a colleague==== | ====Ask a colleague==== | ||
{{hidden|Ask a colleague|<center>This makes me think of [[von Hippel-Lindau]]. Is it unilateral or bilateral?</center>}} | {{hidden|Ask a colleague|<center>This makes me think of [[von Hippel-Lindau disease]]. Is it unilateral or bilateral?</center>}} | ||
====Stains==== | ====Stains==== | ||
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===Diagnosis=== | ===Diagnosis=== | ||
{{hidden|Diagnosis|<center>[[ | {{hidden|Diagnosis|<center>[[Papillary cystadenoma of the epididymis]]</center><br> | ||
Comment:<br>This may occur in [[von Hippel-Lindau disease]]. In the context of von Hippel-Lindau disease, it is usually bilateral and the patient is younger. | |||
The main (morphologic) differential diagnosis is [[clear cell renal cell carcinoma]]. | |||
The immunoprofile of this lesion is like [[clear cell tubulopapillary renal cell carcinoma]] (also known as ''clear cell papillary RCC''); it is CK7 positive, CD10 negative, AMACR negative, PAX8 positive.<ref name=pmid24441657>{{Cite journal | last1 = Cox | first1 = R. | last2 = Vang | first2 = R. | last3 = Epstein | first3 = JI. | title = Papillary cystadenoma of the epididymis and broad ligament: morphologic and immunohistochemical overlap with clear cell papillary renal cell carcinoma. | journal = Am J Surg Pathol | volume = 38 | issue = 5 | pages = 713-8 | month = May | year = 2014 | doi = 10.1097/PAS.0000000000000152 | PMID = 24441657 }}</ref> One should check if there is a kidney mass. | |||
===Reference=== | |||
{{Reflist|1}} | |||
}} | |||
<br> | <br> | ||
===Other cases=== | ===Other cases=== | ||
{{Cases navigation}} | {{Cases navigation}} | ||
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[[Category:Cases in genitourinary pathology]] | [[Category:Cases in genitourinary pathology]] | ||
[[Category:Cases in genitourinary pathology - fellow]] | [[Category:Cases in genitourinary pathology - fellow and expert]] | ||
[[Category:Cases difficulty 6]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level --> | [[Category:Cases difficulty 6]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level --> | ||
Latest revision as of 04:11, 29 September 2015
Provided clinical history
78 year old man
Site
Right epididymis - mass
Primary image
Low magnification
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Intermediate magnification
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High magnification
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Differential diagnosis
Differential diagnosis
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Additional tests
More history
More history
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Ask a colleague
Ask a colleague
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Stains
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IHC
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Molecular testing
Chromosomal translocations
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Other molecular tests
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Diagnosis
Diagnosis
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Comment: The main (morphologic) differential diagnosis is clear cell renal cell carcinoma. The immunoprofile of this lesion is like clear cell tubulopapillary renal cell carcinoma (also known as clear cell papillary RCC); it is CK7 positive, CD10 negative, AMACR negative, PAX8 positive.[1] One should check if there is a kidney mass. Reference
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