Difference between revisions of "WT-1"
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[[File:Wilms_tumor_protein_wt1_immunohistocehmistry_glioblastoma.JPG|thumb|right|250px|WT-1 staining in [[glioblastoma]].]] | |||
'''Wilms Tumor Protein 1''', commonly known by the abbreviation '''WT-1''', is a commonly used [[immunostain]] in [[gynecologic pathology]] and [[neuropathology]]. | '''Wilms Tumor Protein 1''', commonly known by the abbreviation '''WT-1''', is a commonly used [[immunostain]] in [[gynecologic pathology]] and [[neuropathology]]. | ||
==Tumours with positive staining== | ==Tumours with positive staining== | ||
*[[Astrocytoma]]/[[Glioblastoma]] (cytoplasmic) ~80-90% <ref>{{Cite journal | last1 = Schittenhelm | first1 = J. | last2 = Beschorner | first2 = R. | last3 = Simon | first3 = P. | last4 = Tabatabai | first4 = G. | last5 = Herrmann | first5 = C. | last6 = Schlaszus | first6 = H. | last7 = Capper | first7 = D. | last8 = Weller | first8 = M. | last9 = Meyermann | first9 = R. | title = Diagnostic value of WT1 in neuroepithelial tumours. | journal = Neuropathol Appl Neurobiol | volume = 35 | issue = 1 | pages = 69-81 | month = Feb | year = 2009 | doi = 10.1111/j.1365-2990.2008.00957.x | PMID = 18466223 }}</ref> | *[[Astrocytoma]]/[[Glioblastoma]] (cytoplasmic) ~80-90%.<ref name=pmid18466223>{{Cite journal | last1 = Schittenhelm | first1 = J. | last2 = Beschorner | first2 = R. | last3 = Simon | first3 = P. | last4 = Tabatabai | first4 = G. | last5 = Herrmann | first5 = C. | last6 = Schlaszus | first6 = H. | last7 = Capper | first7 = D. | last8 = Weller | first8 = M. | last9 = Meyermann | first9 = R. | title = Diagnostic value of WT1 in neuroepithelial tumours. | journal = Neuropathol Appl Neurobiol | volume = 35 | issue = 1 | pages = 69-81 | month = Feb | year = 2009 | doi = 10.1111/j.1365-2990.2008.00957.x | PMID = 18466223 }}</ref> | ||
*[[ | *[[Malignant mesothelioma]].<ref name=pmid16554731>{{Cite journal | last1 = Yaziji | first1 = H. | last2 = Battifora | first2 = H. | last3 = Barry | first3 = TS. | last4 = Hwang | first4 = HC. | last5 = Bacchi | first5 = CE. | last6 = McIntosh | first6 = MW. | last7 = Kussick | first7 = SJ. | last8 = Gown | first8 = AM. | title = Evaluation of 12 antibodies for distinguishing epithelioid mesothelioma from adenocarcinoma: identification of a three-antibody immunohistochemical panel with maximal sensitivity and specificity. | journal = Mod Pathol | volume = 19 | issue = 4 | pages = 514-23 | month = Apr | year = 2006 | doi = 10.1038/modpathol.3800534 | PMID = 16554731 }}</ref> | ||
* | |||
===Gynecologic pathology=== | |||
*[[Serous ovarian carcinoma]].<ref name=pmid14764054>{{Cite journal | last1 = Al-Hussaini | first1 = M. | last2 = Stockman | first2 = A. | last3 = Foster | first3 = H. | last4 = McCluggage | first4 = WG. | title = WT-1 assists in distinguishing ovarian from uterine serous carcinoma and in distinguishing between serous and endometrioid ovarian carcinoma. | journal = Histopathology | volume = 44 | issue = 2 | pages = 109-15 | month = Feb | year = 2004 | doi = | PMID = 14764054 }}</ref> | |||
===Kidney pathology=== | |||
*[[Wilms tumour]]. | |||
*[[Metanephric adenoma]].<ref name=pmid24083046>{{Cite journal | last1 = Watanabe | first1 = S. | last2 = Naganuma | first2 = H. | last3 = Shimizu | first3 = M. | last4 = Ota | first4 = S. | last5 = Murata | first5 = S. | last6 = Nihei | first6 = N. | last7 = Matsushima | first7 = J. | last8 = Mikami | first8 = S. | last9 = Kuroda | first9 = N. | title = Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases. | journal = Case Rep Pathol | volume = 2013 | issue = | pages = 675875 | month = | year = 2013 | doi = 10.1155/2013/675875 | PMID = 24083046 }}</ref> | |||
==Usually negative== | |||
*[[Serous carcinoma of the endometrium]].<ref name=pmid10786803>{{Cite journal | last1 = Kounelis | first1 = S. | last2 = Kapranos | first2 = N. | last3 = Kouri | first3 = E. | last4 = Coppola | first4 = D. | last5 = Papadaki | first5 = H. | last6 = Jones | first6 = MW. | title = Immunohistochemical profile of endometrial adenocarcinoma: a study of 61 cases and review of the literature. | journal = Mod Pathol | volume = 13 | issue = 4 | pages = 379-88 | month = Apr | year = 2000 | doi = 10.1038/modpathol.3880062 | PMID = 10786803 }}</ref> | |||
==See also== | ==See also== | ||
| Line 11: | Line 21: | ||
==References== | ==References== | ||
{{Reflist|1}} | {{Reflist|1}} | ||
==External links== | |||
*[http://www.nordiqc.org/Epitopes/WT1/WT1.htm WT-1(nordiqc.org)]. | |||
[[Category:Immunohistochemistry]] | [[Category:Immunohistochemistry]] | ||
[[Category:Neuropathology]] | |||
Latest revision as of 06:51, 1 August 2016
WT-1 staining in glioblastoma.
Wilms Tumor Protein 1, commonly known by the abbreviation WT-1, is a commonly used immunostain in gynecologic pathology and neuropathology.
Tumours with positive staining
- Astrocytoma/Glioblastoma (cytoplasmic) ~80-90%.[1]
- Malignant mesothelioma.[2]
Gynecologic pathology
Kidney pathology
Usually negative
See also
References
- ↑ Schittenhelm, J.; Beschorner, R.; Simon, P.; Tabatabai, G.; Herrmann, C.; Schlaszus, H.; Capper, D.; Weller, M. et al. (Feb 2009). "Diagnostic value of WT1 in neuroepithelial tumours.". Neuropathol Appl Neurobiol 35 (1): 69-81. doi:10.1111/j.1365-2990.2008.00957.x. PMID 18466223.
- ↑ Yaziji, H.; Battifora, H.; Barry, TS.; Hwang, HC.; Bacchi, CE.; McIntosh, MW.; Kussick, SJ.; Gown, AM. (Apr 2006). "Evaluation of 12 antibodies for distinguishing epithelioid mesothelioma from adenocarcinoma: identification of a three-antibody immunohistochemical panel with maximal sensitivity and specificity.". Mod Pathol 19 (4): 514-23. doi:10.1038/modpathol.3800534. PMID 16554731.
- ↑ Al-Hussaini, M.; Stockman, A.; Foster, H.; McCluggage, WG. (Feb 2004). "WT-1 assists in distinguishing ovarian from uterine serous carcinoma and in distinguishing between serous and endometrioid ovarian carcinoma.". Histopathology 44 (2): 109-15. PMID 14764054.
- ↑ Watanabe, S.; Naganuma, H.; Shimizu, M.; Ota, S.; Murata, S.; Nihei, N.; Matsushima, J.; Mikami, S. et al. (2013). "Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases.". Case Rep Pathol 2013: 675875. doi:10.1155/2013/675875. PMID 24083046.
- ↑ Kounelis, S.; Kapranos, N.; Kouri, E.; Coppola, D.; Papadaki, H.; Jones, MW. (Apr 2000). "Immunohistochemical profile of endometrial adenocarcinoma: a study of 61 cases and review of the literature.". Mod Pathol 13 (4): 379-88. doi:10.1038/modpathol.3880062. PMID 10786803.