Difference between revisions of "Invasive cribriform carcinoma of the breast"
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'''Invasive cribriform carcinoma of the breast''' is a rare type of [[breast cancer]] with a favourable prognosis.<ref>{{Cite journal | last1 = Cong | first1 = Y. | last2 = Qiao | first2 = G. | last3 = Zou | first3 = H. | last4 = Lin | first4 = J. | last5 = Wang | first5 = X. | last6 = Li | first6 = X. | last7 = Li | first7 = Y. | last8 = Zhu | first8 = S. | title = Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature. | journal = Oncol Lett | volume = 9 | issue = 4 | pages = 1753-1758 | month = Apr | year = 2015 | doi = 10.3892/ol.2015.2972 | PMID = 25789036 }}</ref> | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Breast CribriformCarcinoma MP SNP.jpg | |||
| Width = | |||
| Caption = Invasive cribriform carcinoma of the breast. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = cribriform architecture, stromal desmoplasia, +/-tubular component | |||
| Subtypes = | |||
| LMDDx = [[tubular carcinoma of the breast|tubular carcinoma]], cribriform [[DCIS]], mixed tumour (e.g. ICC with [[invasive ductal carcinoma of the breast|IDC]]), [[adenoid cystic carcinoma of the breast]] | |||
| Stains = | |||
| IHC = ER +ve, PR +ve, HER2 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[breast]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = good | |||
| Other = | |||
| ClinDDx = | |||
| Tx = surgical | |||
}} | |||
'''Invasive cribriform carcinoma of the breast''' is a rare type of [[breast cancer]] with a favourable prognosis.<ref name=pmid25789036>{{Cite journal | last1 = Cong | first1 = Y. | last2 = Qiao | first2 = G. | last3 = Zou | first3 = H. | last4 = Lin | first4 = J. | last5 = Wang | first5 = X. | last6 = Li | first6 = X. | last7 = Li | first7 = Y. | last8 = Zhu | first8 = S. | title = Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature. | journal = Oncol Lett | volume = 9 | issue = 4 | pages = 1753-1758 | month = Apr | year = 2015 | doi = 10.3892/ol.2015.2972 | PMID = 25789036 }}</ref> | |||
==General== | ==General== | ||
*Rare. | *Rare ~ 0.6% of breast cancer in one series.<ref>{{Cite journal | last1 = Stutz | first1 = JA. | last2 = Evans | first2 = AJ. | last3 = Pinder | first3 = S. | last4 = Ellis | first4 = IO. | last5 = Yeoman | first5 = LJ. | last6 = Wilson | first6 = AR. | last7 = Sibbering | first7 = DM. | title = The radiological appearances of invasive cribriform carcinoma of the breast. Nottingham Breast Team. | journal = Clin Radiol | volume = 49 | issue = 10 | pages = 693-5 | month = Oct | year = 1994 | doi = | PMID = 7955831 }}</ref> | ||
*Low | *Low grade. | ||
*Good prognosis if pure or associated with a tubular invasive component.<ref name=pmid6884999>{{Cite journal | last1 = Page | first1 = DL. | last2 = Dixon | first2 = JM. | last3 = Anderson | first3 = TJ. | last4 = Lee | first4 = D. | last5 = Stewart | first5 = HJ. | title = Invasive cribriform carcinoma of the breast. | journal = Histopathology | volume = 7 | issue = 4 | pages = 525-36 | month = Jul | year = 1983 | doi = | PMID = 6884999 }}</ref> | *Good prognosis if pure or associated with a tubular invasive component.<ref name=pmid6884999>{{Cite journal | last1 = Page | first1 = DL. | last2 = Dixon | first2 = JM. | last3 = Anderson | first3 = TJ. | last4 = Lee | first4 = D. | last5 = Stewart | first5 = HJ. | title = Invasive cribriform carcinoma of the breast. | journal = Histopathology | volume = 7 | issue = 4 | pages = 525-36 | month = Jul | year = 1983 | doi = | PMID = 6884999 }}</ref> | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid23412348/> | |||
*[[Cribriform]] (or sieve-like) architecture. | |||
*[[Desmoplastic stroma]]. | |||
*+/-[[Tubular carcinoma of the breast|Tubular]] component. | |||
Notes: | |||
*Cribriform component should be >90% of the tumour.<ref name=pmid23412348>{{Cite journal | last1 = Zhang | first1 = W. | last2 = Zhang | first2 = T. | last3 = Lin | first3 = Z. | last4 = Zhang | first4 = X. | last5 = Liu | first5 = F. | last6 = Wang | first6 = Y. | last7 = Liu | first7 = H. | last8 = Yang | first8 = Y. | last9 = Niu | first9 = Y. | title = Invasive cribriform carcinoma in a Chinese population: comparison with low-grade invasive ductal carcinoma-not otherwise specified. | journal = Int J Clin Exp Pathol | volume = 6 | issue = 3 | pages = 445-57 | month = | year = 2013 | doi = | PMID = 23412348 | PMC = 3563205}}</ref> | |||
*Low or intermediate Nottingham grade. | |||
DDx: | |||
*Cribriform [[DCIS]]. | |||
*[[Tubular carcinoma of the breast]]. | |||
*[[Invasive ductal carcinoma of the breast]] with cribriform component. | |||
*[[Adenoid cystic carcinoma of the breast]]. | |||
===Images=== | ===Images=== | ||
| Line 14: | Line 59: | ||
Image:Breast CribriformCarcinoma HP SNP.jpg|Breast invasive cribriform carcinoma - high power. (SKB) | Image:Breast CribriformCarcinoma HP SNP.jpg|Breast invasive cribriform carcinoma - high power. (SKB) | ||
</gallery> | </gallery> | ||
www: | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563205/figure/fig01/ ICC - panels A-C (nih.gov)].<ref name=pmid23412348/> | |||
==IHC== | ==IHC== | ||
Latest revision as of 03:58, 31 October 2015
| Invasive cribriform carcinoma of the breast | |
|---|---|
| Diagnosis in short | |
 Invasive cribriform carcinoma of the breast. H&E stain. | |
|
| |
| LM | cribriform architecture, stromal desmoplasia, +/-tubular component |
| LM DDx | tubular carcinoma, cribriform DCIS, mixed tumour (e.g. ICC with IDC), adenoid cystic carcinoma of the breast |
| IHC | ER +ve, PR +ve, HER2 -ve |
| Site | breast |
|
| |
| Prevalence | very rare |
| Prognosis | good |
| Treatment | surgical |
Invasive cribriform carcinoma of the breast is a rare type of breast cancer with a favourable prognosis.[1]
General
- Rare ~ 0.6% of breast cancer in one series.[2]
- Low grade.
- Good prognosis if pure or associated with a tubular invasive component.[3]
Microscopic
Features:[4]
- Cribriform (or sieve-like) architecture.
- Desmoplastic stroma.
- +/-Tubular component.
Notes:
- Cribriform component should be >90% of the tumour.[4]
- Low or intermediate Nottingham grade.
DDx:
- Cribriform DCIS.
- Tubular carcinoma of the breast.
- Invasive ductal carcinoma of the breast with cribriform component.
- Adenoid cystic carcinoma of the breast.
Images
Breast invasive cribriform carcinoma - low power. (SKB)
Breast invasive cribriform carcinoma - medium power. (SKB)
Breast invasive cribriform carcinoma - high power. (SKB)
www:
IHC
Features:[1]
- ER +ve (9 +ve of 9 cases).
- PR +ve (9 +ve of 9 cases).
- HER2 -ve (0 +ve of 9 cases).
See also
References
- ↑ 1.0 1.1 Cong, Y.; Qiao, G.; Zou, H.; Lin, J.; Wang, X.; Li, X.; Li, Y.; Zhu, S. (Apr 2015). "Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature.". Oncol Lett 9 (4): 1753-1758. doi:10.3892/ol.2015.2972. PMID 25789036.
- ↑ Stutz, JA.; Evans, AJ.; Pinder, S.; Ellis, IO.; Yeoman, LJ.; Wilson, AR.; Sibbering, DM. (Oct 1994). "The radiological appearances of invasive cribriform carcinoma of the breast. Nottingham Breast Team.". Clin Radiol 49 (10): 693-5. PMID 7955831.
- ↑ Page, DL.; Dixon, JM.; Anderson, TJ.; Lee, D.; Stewart, HJ. (Jul 1983). "Invasive cribriform carcinoma of the breast.". Histopathology 7 (4): 525-36. PMID 6884999.
- ↑ 4.0 4.1 4.2 Zhang, W.; Zhang, T.; Lin, Z.; Zhang, X.; Liu, F.; Wang, Y.; Liu, H.; Yang, Y. et al. (2013). "Invasive cribriform carcinoma in a Chinese population: comparison with low-grade invasive ductal carcinoma-not otherwise specified.". Int J Clin Exp Pathol 6 (3): 445-57. PMC 3563205. PMID 23412348. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563205/.