Difference between revisions of "Placental alkaline phosphatase"
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'''Placental alkaline phosphatase''', abbreviated '''PLAP''', is a common | {{ Infobox immunostain | ||
| Name = {{PAGENAME}} | |||
| Image = ITGCN and Sertoli cells only - PLAP -- high mag.jpg | |||
| Width = | |||
| Caption = PLAP in [[germ cell neoplasia in situ]] - left of image. (WC) | |||
| Abbrev = PLAP | |||
| Synonyms = | |||
| Similar = OCT4, OCT3/4 | |||
| Clones = | |||
| Use = [[germ cell tumours]] | |||
| Subspecial = [[genitourinary pathology]], [[gynecologic pathology]] | |||
| Pattern = membranous | |||
| Positive = [[germ cell neoplasia in situ]] (previously ITGCN), [[seminoma]], [[embryonal carcinoma]] | |||
| Negative = normal testis, Sertoli cells only | |||
| Other = | |||
}} | |||
'''Placental alkaline phosphatase''', abbreviated '''PLAP''', is a common [[immunostain]] used for assessing suspected [[germ cell tumours]]. | |||
It has largely been replaced by OCT4. | It has largely been replaced by OCT4. | ||
| Line 5: | Line 21: | ||
==Negative== | ==Negative== | ||
*Normal [[testis]].<ref name=pmid9104938>{{Cite journal | last1 = Hawkins | first1 = E. | last2 = Heifetz | first2 = SA. | last3 = Giller | first3 = R. | last4 = Cushing | first4 = B. | title = The prepubertal testis (prenatal and postnatal): its relationship to intratubular germ cell neoplasia: a combined Pediatric Oncology Group and Children's Cancer Study Group. | journal = Hum Pathol | volume = 28 | issue = 4 | pages = 404-10 | month = Apr | year = 1997 | doi = | PMID = 9104938 }}</ref> | *Normal [[testis]].<ref name=pmid9104938>{{Cite journal | last1 = Hawkins | first1 = E. | last2 = Heifetz | first2 = SA. | last3 = Giller | first3 = R. | last4 = Cushing | first4 = B. | title = The prepubertal testis (prenatal and postnatal): its relationship to intratubular germ cell neoplasia: a combined Pediatric Oncology Group and Children's Cancer Study Group. | journal = Hum Pathol | volume = 28 | issue = 4 | pages = 404-10 | month = Apr | year = 1997 | doi = | PMID = 9104938 }}</ref> | ||
*Sertoli cells only. | |||
==Positive== | ==Positive== | ||
*[[ | *[[Germ cell neoplasia in situ]] (intratubular germ cell neoplasia).<ref name=pmid12598912>{{Cite journal | last1 = Schreiber | first1 = L. | last2 = Lifschitz-Mercer | first2 = B. | last3 = Paz | first3 = G. | last4 = Yavetz | first4 = H. | last5 = Elliott | first5 = DJ. | last6 = Kula | first6 = K. | last7 = Slowikowska-Hilczer | first7 = J. | last8 = Maymon | first8 = BB. | title = Double immunolabeling by the RBM and the PLAP markers for identifying intratubular (in situ) germ cell neoplasia of the testis. | journal = Int J Surg Pathol | volume = 11 | issue = 1 | pages = 17-20 | month = Jan | year = 2003 | doi = | PMID = 12598912 }}</ref> | ||
*[[Seminoma]]. | |||
*[[Embryonal carcinoma]]. | |||
===Images=== | |||
<gallery> | |||
Image: ITGCN and Sertoli cells only - PLAP -- intermed mag.jpg | [[Germ cell neoplasia in situ]] (GCNIS) & Sertoli cells only (SCO) - intermed. mag. | |||
Image: ITGCN and Sertoli cells only - PLAP -- high mag.jpg | GCNIS & SCO - high mag. | |||
Image: ITGCN and Sertoli cells only - PLAP -- very high mag.jpg | GCNIS & SCO - very high mag. | |||
</gallery> | |||
==See also== | ==See also== | ||
| Line 14: | Line 40: | ||
==References== | ==References== | ||
{{Reflist|2}} | |||
[[Category:Immunohistochemistry]] | [[Category:Immunohistochemistry]] | ||
Latest revision as of 19:06, 8 January 2017
| Placental alkaline phosphatase | |
|---|---|
| Immunostain in short | |
 PLAP in germ cell neoplasia in situ - left of image. (WC) | |
| Abbreviation | PLAP |
| Similar stains | OCT4, OCT3/4 |
| Use | germ cell tumours |
| Subspeciality | genitourinary pathology, gynecologic pathology |
| Normal staining pattern | membranous |
| Positive | germ cell neoplasia in situ (previously ITGCN), seminoma, embryonal carcinoma |
| Negative | normal testis, Sertoli cells only |
Placental alkaline phosphatase, abbreviated PLAP, is a common immunostain used for assessing suspected germ cell tumours.
It has largely been replaced by OCT4.
Negative
Positive
- Germ cell neoplasia in situ (intratubular germ cell neoplasia).[2]
- Seminoma.
- Embryonal carcinoma.
Images
Germ cell neoplasia in situ (GCNIS) & Sertoli cells only (SCO) - intermed. mag.
GCNIS & SCO - high mag.
GCNIS & SCO - very high mag.
See also
References
- ↑ Hawkins, E.; Heifetz, SA.; Giller, R.; Cushing, B. (Apr 1997). "The prepubertal testis (prenatal and postnatal): its relationship to intratubular germ cell neoplasia: a combined Pediatric Oncology Group and Children's Cancer Study Group.". Hum Pathol 28 (4): 404-10. PMID 9104938.
- ↑ Schreiber, L.; Lifschitz-Mercer, B.; Paz, G.; Yavetz, H.; Elliott, DJ.; Kula, K.; Slowikowska-Hilczer, J.; Maymon, BB. (Jan 2003). "Double immunolabeling by the RBM and the PLAP markers for identifying intratubular (in situ) germ cell neoplasia of the testis.". Int J Surg Pathol 11 (1): 17-20. PMID 12598912.