Difference between revisions of "Colorectal xanthomatous polyp"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Xanthomatous polyp -- intermed mag.jpg | |||
| Width = | |||
| Caption = Colorectal xanthomatous polyp. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = abundant foamy histiocytes in the superficial lamina propria +/- superficial serrations (hyperplastic features) | |||
| Subtypes = | |||
| LMDDx = [[hyperplastic polyp]], [[signet ring cell carcinoma]], others | |||
| Stains = | |||
| IHC = CD68 +ve, pankeratin -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[colon]], [[rectum]] | |||
| Assdx = +/-hyperlipidemia | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = polyp - red or yellow colour | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = other [[colorectal polyps]] | |||
| Tx = | |||
}} | |||
The '''colorectal xanthomatous polyp''', also '''colorectal xanthoma''', is a rare benign [[intestinal polyp]]. | The '''colorectal xanthomatous polyp''', also '''colorectal xanthoma''', is a rare benign [[intestinal polyp]]. | ||
'''Rectal xanthoma''', '''colonic xanthoma''', '''rectal xanthelasma''' and '''colonic xanthelasma''' redirect here. | |||
''Colorectal xanthomatous polyp'' may be abbreviated '''CXP'''. | |||
==General== | ==General== | ||
*Rare. | *Rare.<ref name=pmid12009096>{{Cite journal | last1 = Miliauskas | first1 = JR. | title = Rectosigmoid (colonic) xanthoma: a report of four cases and review of the literature. | journal = Pathology | volume = 34 | issue = 2 | pages = 144-7 | month = Apr | year = 2002 | doi = | PMID = 12009096 }}</ref> | ||
*May be associated with hyperlipidemia (7/25 patients in one series<ref name=pmid14961968>{{Cite journal | last1 = Nakasono | first1 = M. | last2 = Hirokawa | first2 = M. | last3 = Muguruma | first3 = N. | last4 = Okahisa | first4 = T. | last5 = Okamura | first5 = S. | last6 = Ito | first6 = S. | last7 = Miyamoto | first7 = H. | last8 = Wada | first8 = S. | last9 = Fukuda | first9 = T. | title = Colorectal xanthomas with polypoid lesion: report of 25 cases. | journal = APMIS | volume = 112 | issue = 1 | pages = 3-10 | month = Jan | year = 2004 | doi = | PMID = 14961968 }}</ref>). | *May be associated with hyperlipidemia (7/25 patients in one series<ref name=pmid14961968>{{Cite journal | last1 = Nakasono | first1 = M. | last2 = Hirokawa | first2 = M. | last3 = Muguruma | first3 = N. | last4 = Okahisa | first4 = T. | last5 = Okamura | first5 = S. | last6 = Ito | first6 = S. | last7 = Miyamoto | first7 = H. | last8 = Wada | first8 = S. | last9 = Fukuda | first9 = T. | title = Colorectal xanthomas with polypoid lesion: report of 25 cases. | journal = APMIS | volume = 112 | issue = 1 | pages = 3-10 | month = Jan | year = 2004 | doi = | PMID = 14961968 }}</ref>). | ||
==Gross== | |||
*Usually red colour.<ref name=pmid14961968/> | |||
**Classically described as ''yellow''.<ref name=pmid12009096/><ref name=pmid14961968/> | |||
==Microscopic== | ==Microscopic== | ||
| Line 14: | Line 53: | ||
*[[Hyperplastic polyp of the colon|Hyperplastic polyp]]. | *[[Hyperplastic polyp of the colon|Hyperplastic polyp]]. | ||
*[[Signet ring cell carcinoma]]. | *[[Signet ring cell carcinoma]]. | ||
*[[Whipple disease]]. | |||
*[[Mycobacterium avium complex]]. | |||
===Images=== | |||
<gallery> | |||
Image: Xanthomatous polyp -- very low mag.jpg | XP - very low mag. | |||
Image: Xanthomatous polyp -- low mag.jpg | XP - low mag. | |||
Image: Xanthomatous polyp -- intermed mag.jpg | XP - intermed. mag. | |||
Image: Xanthomatous polyp - alt -- intermed mag.jpg | XP - intermed. mag. | |||
Image: Xanthomatous polyp -- high mag.jpg | XP - high mag. | |||
Image: Xanthomatous polyp -- very high mag.jpg | XP - very high mag. | |||
Image: Xanthomatous polyp - a2 -- very high mag.jpg | XP - very high mag. | |||
</gallery> | |||
==Stains== | |||
*[[ZN stain]] -ve. | |||
*[[PAS stain]] -ve. | |||
==IHC== | |||
*CD68 +ve (foamy histiocytes).<ref name=pmid12009096/> | |||
*Pankeratin -ve. | |||
==Sign out== | ==Sign out== | ||
<pre> | |||
Polyp, Rectum, Polypectomy or Biopsy: | |||
- Xanthomatous polyp with hyperplastic features, see comment. | |||
- NEGATIVE for dysplasia. | |||
COMMENT: | |||
Xanthomatous polyps may be seen in the context of hyperlipidemia.[1] A lipid | |||
profile could be considered. | |||
1. APMIS 112 (1): 3-10. PMID: 14961968. | |||
</pre> | |||
===Block letters=== | |||
<pre> | <pre> | ||
POLYP, SIGMOID COLON, POLYPECTOMY: | POLYP, SIGMOID COLON, POLYPECTOMY: | ||
| Line 22: | Line 94: | ||
COMMENT: | COMMENT: | ||
Xanthomatous polyps may be seen in the context of hyperlipidemia. | Xanthomatous polyps may be seen in the context of hyperlipidemia.[1] A lipid | ||
profile could be considered. | |||
1. APMIS 112 (1): 3-10. PMID: 14961968. | |||
</pre> | </pre> | ||
==See also== | ==See also== | ||
*[[Intestinal polyps]]. | *[[Intestinal polyps]]. | ||
*[[Gastric xanthoma]]. | |||
*[[Urinary bladder xanthoma]]. | |||
==References== | ==References== | ||
Latest revision as of 19:13, 24 October 2022
| Colorectal xanthomatous polyp | |
|---|---|
| Diagnosis in short | |
 Colorectal xanthomatous polyp. H&E stain. | |
|
| |
| LM | abundant foamy histiocytes in the superficial lamina propria +/- superficial serrations (hyperplastic features) |
| LM DDx | hyperplastic polyp, signet ring cell carcinoma, others |
| IHC | CD68 +ve, pankeratin -ve |
| Site | colon, rectum |
|
| |
| Associated Dx | +/-hyperlipidemia |
| Prevalence | uncommon |
| Endoscopy | polyp - red or yellow colour |
| Prognosis | benign |
| Clin. DDx | other colorectal polyps |
The colorectal xanthomatous polyp, also colorectal xanthoma, is a rare benign intestinal polyp.
Rectal xanthoma, colonic xanthoma, rectal xanthelasma and colonic xanthelasma redirect here.
Colorectal xanthomatous polyp may be abbreviated CXP.
General
Gross
Microscopic
Features:
- Abundant foamy histiocytes in the superficial lamina propria.
- +/-Superficial serrations (hyperplastic features).
- Seen in ~80% of cases.[2]
DDx:
Images
XP - very low mag.
XP - low mag.
XP - intermed. mag.
XP - intermed. mag.
XP - high mag.
XP - very high mag.
XP - very high mag.
Stains
IHC
- CD68 +ve (foamy histiocytes).[1]
- Pankeratin -ve.
Sign out
Polyp, Rectum, Polypectomy or Biopsy: - Xanthomatous polyp with hyperplastic features, see comment. - NEGATIVE for dysplasia. COMMENT: Xanthomatous polyps may be seen in the context of hyperlipidemia.[1] A lipid profile could be considered. 1. APMIS 112 (1): 3-10. PMID: 14961968.
Block letters
POLYP, SIGMOID COLON, POLYPECTOMY: - XANTHOMATOUS POLYP WITH HYPERPLASTIC FEATURES. - NEGATIVE FOR DYSPLASIA. COMMENT: Xanthomatous polyps may be seen in the context of hyperlipidemia.[1] A lipid profile could be considered. 1. APMIS 112 (1): 3-10. PMID: 14961968.
See also
References
- ↑ 1.0 1.1 1.2 Miliauskas, JR. (Apr 2002). "Rectosigmoid (colonic) xanthoma: a report of four cases and review of the literature.". Pathology 34 (2): 144-7. PMID 12009096.
- ↑ 2.0 2.1 2.2 2.3 Nakasono, M.; Hirokawa, M.; Muguruma, N.; Okahisa, T.; Okamura, S.; Ito, S.; Miyamoto, H.; Wada, S. et al. (Jan 2004). "Colorectal xanthomas with polypoid lesion: report of 25 cases.". APMIS 112 (1): 3-10. PMID 14961968.