Difference between revisions of "Hyalinizing clear cell carcinoma"
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| Micro = cells with abundant clear cytoplasm in cords, trabeculae or clusters; minimal [[nuclear pleomorphism]]; hyalinized stroma | | Micro = cells with abundant clear cytoplasm in cords, trabeculae or clusters; minimal [[nuclear pleomorphism]]; hyalinized stroma | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[mucoepidermoid carcinoma]] (clear cell variant), [[acinic cell carcinoma]] (clear cell variant), metastatic [[clear cell renal cell carcinoma]], [[epithelial-myoepithelial carcinoma]], other [[clear cell tumours]] | ||
| Stains = PAS +ve | | Stains = PAS +ve | ||
| IHC = AE1/AE3 +ve, EMA +ve. | | IHC = AE1/AE3 +ve, EMA +ve. | ||
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| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = usu. palate or tongue | | Site = usu. palate or [[tongue]] | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
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*Clear cytoplasm due to glycogen.<ref name=pmid7506496>{{Cite journal | last1 = Milchgrub | first1 = S. | last2 = Gnepp | first2 = DR. | last3 = Vuitch | first3 = F. | last4 = Delgado | first4 = R. | last5 = Albores-Saavedra | first5 = J. | title = Hyalinizing clear cell carcinoma of salivary gland. | journal = Am J Surg Pathol | volume = 18 | issue = 1 | pages = 74-82 | month = Jan | year = 1994 | doi = | PMID = 7506496 }}</ref> | *Clear cytoplasm due to glycogen.<ref name=pmid7506496>{{Cite journal | last1 = Milchgrub | first1 = S. | last2 = Gnepp | first2 = DR. | last3 = Vuitch | first3 = F. | last4 = Delgado | first4 = R. | last5 = Albores-Saavedra | first5 = J. | title = Hyalinizing clear cell carcinoma of salivary gland. | journal = Am J Surg Pathol | volume = 18 | issue = 1 | pages = 74-82 | month = Jan | year = 1994 | doi = | PMID = 7506496 }}</ref> | ||
*Low mitotic rate. | *Low mitotic rate. | ||
*Should ''not'' have epidermoid or mucinous differentiation - seen in clear cell variant of mucoepidermoid carcinoma. | |||
DDx: | DDx: | ||
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*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig2/ HCCC (nlm.nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig2/ HCCC (nlm.nih.gov)]. | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig5/ HCCC (nlm.nih.gov)].<ref name=pmid20596970/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig5/ HCCC (nlm.nih.gov)].<ref name=pmid20596970/> | ||
==Stains== | ==Stains== | ||
*PAS +ve. | *PAS +ve. | ||
Latest revision as of 16:00, 13 March 2016
| Hyalinizing clear cell carcinoma | |
|---|---|
| Diagnosis in short | |
 Hyalinizing clear cell carcinoma. H&E stain. | |
|
| |
| LM | cells with abundant clear cytoplasm in cords, trabeculae or clusters; minimal nuclear pleomorphism; hyalinized stroma |
| LM DDx | mucoepidermoid carcinoma (clear cell variant), acinic cell carcinoma (clear cell variant), metastatic clear cell renal cell carcinoma, epithelial-myoepithelial carcinoma, other clear cell tumours |
| Stains | PAS +ve |
| IHC | AE1/AE3 +ve, EMA +ve. |
| Molecular | t(12;22) -- EWSR1/ATF1 |
| Site | usu. palate or tongue |
|
| |
| Prevalence | rare |
| Prognosis | good |
Hyalinizing clear cell carcinoma, abbreviated HCCC, is a rare malignant head and neck tumour with a good prognosis.
General
Microscopic
Features:[3]
- Groups of cells with abundant clear cytoplasm.
- Arranged in cords, trabeculae or clusters.
- Minimal nuclear pleomorphism.[4]
- Hyalinized stroma.
Notes:
- Clear cytoplasm due to glycogen.[4]
- Low mitotic rate.
- Should not have epidermoid or mucinous differentiation - seen in clear cell variant of mucoepidermoid carcinoma.
DDx:
- Mucoepidermoid carcinoma, clear cell variant.
- Acinic cell carcinoma, clear cell variant.
- Metastatic clear cell renal cell carcinoma.
- Classically have hemorrhage & necrosis.
- Epithelial-myoepithelial carcinoma.
- Other clear cell tumours.
Images
HCCC - intermed. mag. (WC/Nephron)
HCCC - high mag. (WC/Nephron)
HCCC - very high mag. (WC/Nephron)
www:
Stains
- PAS +ve.
IHC
- AE1/AE3 +ve.
- EMA +ve.[4]
Others:
Molecular
Recurrent translocation:[5]
- t(12;22) -- EWSR1/ATF1.
- Same translocation as in clear cell sarcoma.
See also
References
- ↑ Masilamani, S.; Rao, S.; Chirakkal, P.; Kumar, AR.. "Hyalinizing clear cell carcinoma of the base of tongue: a distinct and rare entity.". Indian J Pathol Microbiol 54 (1): 167-9. doi:10.4103/0377-4929.77393. PMID 21393908.
- ↑ Kauzman, A.; Tabet, JC.; Stiharu, TI. (Jul 2011). "Hyalinizing clear cell carcinoma: a case report and review of the literature.". Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112 (1): e26-34. doi:10.1016/j.tripleo.2011.02.041. PMID 21669357.
- ↑ 3.0 3.1 O'Sullivan-Mejia, ED.; Massey, HD.; Faquin, WC.; Powers, CN. (Sep 2009). "Hyalinizing clear cell carcinoma: report of eight cases and a review of literature.". Head Neck Pathol 3 (3): 179-85. doi:10.1007/s12105-009-0124-3. PMID 20596970.
- ↑ 4.0 4.1 4.2 4.3 4.4 Milchgrub, S.; Gnepp, DR.; Vuitch, F.; Delgado, R.; Albores-Saavedra, J. (Jan 1994). "Hyalinizing clear cell carcinoma of salivary gland.". Am J Surg Pathol 18 (1): 74-82. PMID 7506496.
- ↑ Antonescu, CR.; Katabi, N.; Zhang, L.; Sung, YS.; Seethala, RR.; Jordan, RC.; Perez-Ordoñez, B.; Have, C. et al. (Jul 2011). "EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland.". Genes Chromosomes Cancer 50 (7): 559-70. doi:10.1002/gcc.20881. PMID 21484932.