Difference between revisions of "Endometrium with changes due to exogenous hormones"

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{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      = Endometrium_ocp_use3.jpg
| Image      = Endometrium with hormone effect -- high mag.jpg
| Width      =
| Width      =
| Caption    = Endometrium with hormonal changes due to the [[OCP]]. [[H&E stain]].
| Caption    = Endometrium with changes due to exogenous hormones. [[H&E stain]].
| Micro      = inactive glands (round/ovoid glands, simple cuboidal epithelium, no mitoses), decidualized stroma (nucleus central, eosinophilic cytoplasm, well-defined cell borders)
| Micro      = inactive glands (round/ovoid glands, simple cuboidal epithelium, no mitoses), decidualized stroma (nucleus central, eosinophilic cytoplasm, well-defined cell borders)
| Subtypes  =
| Subtypes  =
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==General==
==General==
*Very common.
*Very common.
*Most pills a mix of progesterone and estrogen.
*Most pills are a mix of progesterone and estrogen.
**The progesterone is what generates the characteristic appearance -- that is similar to pregnancy.
**The progesterone is what generates the characteristic appearance -- that is similar to [[pregnancy]].
*Same appearance is seen with a levonorgestrel-releasing intrauterine device, e.g. ''Mirena''.
*Same appearance is seen with a levonorgestrel-releasing intrauterine device, e.g. ''Mirena''.


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Image:Endometrium_ocp_use2.jpg | Endometrium of woman on an OCP. (WC/Nephron)
Image:Endometrium_ocp_use2.jpg | Endometrium of woman on an OCP. (WC/Nephron)
Image:Endometrium_ocp_use3.jpg | Endometrium of woman on an OCP. (WC/Nephron)
Image:Endometrium_ocp_use3.jpg | Endometrium of woman on an OCP. (WC/Nephron)
</gallery>
<gallery>
Image: Endometrium with hormone effect -- intermed mag.jpg | Hormone effect - intermed. mag. (WC)
Image: Endometrium with hormone effect -- high mag.jpg | Hormone effect - high mag. (WC)
Image: Endometrium with hormone effect -- very high mag.jpg | Hormone effect - very high mag. (WC)
</gallery>
</gallery>
==Sign out==
==Sign out==
<pre>
Endometrium, Curettage:
- Endometrium with nonproliferative endometrial glands and stromal decidualization,
  consistent with exogenous hormones.
</pre>
====Block letters====
<pre>
<pre>
ENDOMETRIUM, BIOPSY:
ENDOMETRIUM, BIOPSY:
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- NEGATIVE FOR HYPERPLASIA AND NEGATIVE FOR MALIGNANCY.
- NEGATIVE FOR HYPERPLASIA AND NEGATIVE FOR MALIGNANCY.
</pre>
</pre>
===Micro===
The sections show endometrium with nonproliferative endometrial glands and stromal
decidualization. The gland-to-stroma ratio is within normal limits.


==See also==
==See also==
*[[Endometrium]].
*[[Endometrium]].
*[[Endometrial hyperplasia with secretory changes]].
*[[Endometrial hyperplasia with secretory changes]].
*[[Decidualized endometrium]].


==References==
==References==

Latest revision as of 14:47, 27 November 2015

Endometrium with changes due to exogenous hormones
Diagnosis in short

Endometrium with changes due to exogenous hormones. H&E stain.
LM inactive glands (round/ovoid glands, simple cuboidal epithelium, no mitoses), decidualized stroma (nucleus central, eosinophilic cytoplasm, well-defined cell borders)
LM DDx endometrial hyperplasia with secretory changes, secretory phase endometrium
Site endometrium
Clinical history exogenous hormones (oral contraceptive pill or hormone releasing intrauterine device)
Prognosis benign
Endometrium with changes due to exogenous hormones
External resources
EHVSC 10170

Endometrium with changes due to exogenous hormones is relatively common in endometrial samples.

Endometrial changes of oral contraception, oral contraceptive effect, OCP endometrium, and endometrium with hormonal changes redirect here.

The oral contraceptive pill is dealt with in the article oral contraceptive pill.

General

  • Very common.
  • Most pills are a mix of progesterone and estrogen.
    • The progesterone is what generates the characteristic appearance -- that is similar to pregnancy.
  • Same appearance is seen with a levonorgestrel-releasing intrauterine device, e.g. Mirena.

Microscopic

Features:[1]

  • Inactive glands (round/ovoid glands, simple cuboidal epithelium, no mitoses).
  • Stroma decidualized -- mnemonic NEW:
    • Nucleus central.
    • Eosinophilic cytoplasm.
    • Well-defined cell borders.

DDx:

Image

  • Endometrium of woman on an OCP. (WC/Nephron)

  • Endometrium of woman on an OCP. (WC/Nephron)

  • Endometrium of woman on an OCP. (WC/Nephron)

  • Hormone effect - intermed. mag. (WC)

  • Hormone effect - high mag. (WC)

  • Hormone effect - very high mag. (WC)

Sign out

Endometrium, Curettage:
- Endometrium with nonproliferative endometrial glands and stromal decidualization,
  consistent with exogenous hormones.

Block letters

ENDOMETRIUM, BIOPSY:
- NON-PROLIFERATIVE ENDOMETRIAL GLANDS WITH STROMAL DECIDUALIZATION, CONSISTENT 
  WITH EXOGENOUS HORMONES.

OCP effect and shedding endometrium

ENDOMETRIUM, ASPIRATION:
- ENDOMETRIUM WITH NONPROLIFERATIVE ENDOMETRIAL GLANDS AND
  STROMAL DECIDUALIZATION, COMPATIBLE WITH EXOGENOUS HORMONES.
- EVIDENCE OF ENDOMETRIAL SHEDDING (BALLS OF CONDENSED STROMA
  ASSOCIATED NEUTROPHILS, AND BLOOD).
- NEGATIVE FOR HYPERPLASIA AND NEGATIVE FOR MALIGNANCY.

Micro

The sections show endometrium with nonproliferative endometrial glands and stromal decidualization. The gland-to-stroma ratio is within normal limits.

See also

References

  1. ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1082. ISBN 0-7216-0187-1.
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