Difference between revisions of "Gastric xanthoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Gastric_Xanthelasma,_HE_03.jpg | |||
| Width = | |||
| Caption = Gastric xanthoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = gastric lamina propria with lipid-laden macrophages | |||
| Subtypes = | |||
| LMDDx = [[signet ring cell carcinoma]], [[Whipple disease]], [[MAI]] infection | |||
| Stains = | |||
| IHC = CD68 +ve, AE1/AE3 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = yellowish nodule or plaque - usu. lesser curvature | |||
| Grossing = | |||
| Site = [[stomach]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Gastric xanthoma''', abbreviated ''GX'', is an uncommon benign lesion of the stomach. | '''Gastric xanthoma''', abbreviated ''GX'', is an uncommon benign lesion of the stomach. | ||
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=Ref_GLP111>{{Ref GLP|111}}</ref> | Features:<ref name=Ref_GLP111>{{Ref GLP|111}}</ref> | ||
*Collections of | *Collections of lipid-laden macrophages within the gastric lamina propria. | ||
DDx: | DDx: | ||
*[[Signet ring cell carcinoma]].<ref name=pmid6284833>{{Cite journal | last1 = Drude | first1 = RB. | last2 = Balart | first2 = LA. | last3 = Herrington | first3 = JP. | last4 = Beckman | first4 = EN. | last5 = Burns | first5 = TW. | title = Gastric xanthoma: histologic similarity to signet ring cell carcinoma. | journal = J Clin Gastroenterol | volume = 4 | issue = 3 | pages = 217-21 | month = Jun | year = 1982 | doi = | PMID = 6284833 }}</ref> | *[[Signet ring cell carcinoma]].<ref name=pmid6284833>{{Cite journal | last1 = Drude | first1 = RB. | last2 = Balart | first2 = LA. | last3 = Herrington | first3 = JP. | last4 = Beckman | first4 = EN. | last5 = Burns | first5 = TW. | title = Gastric xanthoma: histologic similarity to signet ring cell carcinoma. | journal = J Clin Gastroenterol | volume = 4 | issue = 3 | pages = 217-21 | month = Jun | year = 1982 | doi = | PMID = 6284833 }}</ref> | ||
*[[Whipple disease]]. | *[[Whipple disease]]. | ||
*MAC infection. | *[[MAC infection]]. | ||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image:Gastric Xanthelasma, HE 01.jpg|GX. (WC) | |||
Image:Gastric Xanthelasma, HE 02.jpg|GX. (WC) | |||
Image:Gastric Xanthelasma, HE 03.jpg|GX. (WC) | |||
Image:Gastric Xanthelasma, CD68.jpg|GX - CD68. (WC) | |||
</gallery> | |||
<gallery> | |||
Image:Xanthoma_histology.jpg | Xanthoma. (WC) | |||
</gallery> | </gallery> | ||
www: | www: | ||
| Line 31: | Line 68: | ||
*Panker (AE1/AE3) -ve. | *Panker (AE1/AE3) -ve. | ||
**To exclude carcinoma. | **To exclude carcinoma. | ||
==Sign out== | |||
<pre> | |||
Stomach, Cardia Lesion, Biopsy: | |||
- Polypoid gastric xanthoma. | |||
- NEGATIVE for Helicobacter-like organisms. | |||
- NEGATIVE for intestinal metaplasia. | |||
- NEGATIVE for dysplasia and NEGATIVE for malignancy. | |||
Comment: | |||
The histiocytes in were demonstrated with a CD68 immunostain. | |||
An AE1/AE3 immunostain and a Ki-67 immunostain have a benign pattern. | |||
</pre> | |||
==See also== | ==See also== | ||
*[[Stomach]]. | *[[Stomach]]. | ||
*[[Colorectal xanthoma]]. | |||
==References== | ==References== | ||
Latest revision as of 16:21, 10 December 2019
| Gastric xanthoma | |
|---|---|
| Diagnosis in short | |
 Gastric xanthoma. H&E stain. | |
|
| |
| LM | gastric lamina propria with lipid-laden macrophages |
| LM DDx | signet ring cell carcinoma, Whipple disease, MAI infection |
| IHC | CD68 +ve, AE1/AE3 -ve |
| Gross | yellowish nodule or plaque - usu. lesser curvature |
| Site | stomach |
|
| |
| Prevalence | uncommon |
| Prognosis | benign |
Gastric xanthoma, abbreviated GX, is an uncommon benign lesion of the stomach.
It is also known as xanthelasma and stomach lipidosis.
General
- Uncommon.
- Benign.
Gross/endoscopic
Microscopic
Features:[1]
- Collections of lipid-laden macrophages within the gastric lamina propria.
DDx:
Images
GX. (WC)
GX. (WC)
GX. (WC)
GX - CD68. (WC)
Xanthoma. (WC)
www:
IHC
- CD68 +ve.
- Panker (AE1/AE3) -ve.
- To exclude carcinoma.
Sign out
Stomach, Cardia Lesion, Biopsy:
- Polypoid gastric xanthoma.
- NEGATIVE for Helicobacter-like organisms.
- NEGATIVE for intestinal metaplasia.
- NEGATIVE for dysplasia and NEGATIVE for malignancy.
Comment:
The histiocytes in were demonstrated with a CD68 immunostain.
An AE1/AE3 immunostain and a Ki-67 immunostain have a benign pattern.
See also
References
- ↑ 1.0 1.1 Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 111. ISBN 978-0443066573.
- ↑ 2.0 2.1 Drude, RB.; Balart, LA.; Herrington, JP.; Beckman, EN.; Burns, TW. (Jun 1982). "Gastric xanthoma: histologic similarity to signet ring cell carcinoma.". J Clin Gastroenterol 4 (3): 217-21. PMID 6284833.