Difference between revisions of "Desmoplasia"
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'''Desmoplasia''' is the formation | '''Desmoplasia''' is the formation of fibrous connective tissue.<ref>URL: [http://www.merriam-webster.com/medical/desmoplasia http://www.merriam-webster.com/medical/desmoplasia]. Accessed on: 2 May 2013.</ref> It is also known as the '''desmoplastic response''', '''desmoplastic stroma''', '''desmoplastic stromal response''', and '''stromal response'''. | ||
It is a stromal change that in the context of dysplasia supports the diagnosis of an invasive carcinoma. | It is a stromal change that in the context of dysplasia supports the diagnosis of an invasive [[carcinoma]]. | ||
==Microscopic== | ==Microscopic== | ||
Features: | |||
*Increased stromal cellularity - '''key feature'''. | *Increased stromal cellularity - '''key feature'''. | ||
**Large (plump) spindle cells (fibroblasts) with | **Large (plump) spindle cells (fibroblasts)‡ with (large) nuclei that are pale in relation to the tumour cells. | ||
*Edema - pale spaces between the cells - may be apparent at low power.<ref>{{Ref TPoSP|15}}</ref> | *Edema - pale spaces between the cells - may be apparent at low power.<ref>{{Ref TPoSP|15}}</ref> | ||
Note: | |||
*‡ Large (plump) spindle cells: the nuclei have approximately the width of a resting lymphocyte. | |||
DDx: | DDx: | ||
*[[Sclerosing adenosis]]. | *[[Sclerosing adenosis]]. | ||
Image: | ===Images=== | ||
<gallery> | |||
Image:Cecal_adenocarcinoma.jpg | Desmoplasia in a cecal adenocarcinoma. (WC/Nephron) | |||
Image:Colorectal adenocarcinoma - alt -- high mag.jpg | Desmoplasia in colorectal carcinoma. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/ASSETS/Slide329SCChp.JPG Desmoplasia in cervical SCC (ucsf.edu)].<ref name=uscf>URL: [http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/homepage.htm http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/homepage.htm]. Accessed on: 2 May 2013.</ref> | *[http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/ASSETS/Slide329SCChp.JPG Desmoplasia in cervical SCC (ucsf.edu)].<ref name=uscf>URL: [http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/homepage.htm http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/homepage.htm]. Accessed on: 2 May 2013.</ref> | ||
| Line 19: | Line 27: | ||
*[[Cancer]]. | *[[Cancer]]. | ||
*[[Basics]]. | *[[Basics]]. | ||
*[[Nuclear atypia]]. | |||
*[[Nuclear pleomorphism]]. | |||
==References== | ==References== | ||
Latest revision as of 20:08, 6 December 2018
Desmoplasia is the formation of fibrous connective tissue.[1] It is also known as the desmoplastic response, desmoplastic stroma, desmoplastic stromal response, and stromal response.
It is a stromal change that in the context of dysplasia supports the diagnosis of an invasive carcinoma.
Microscopic
Features:
- Increased stromal cellularity - key feature.
- Large (plump) spindle cells (fibroblasts)‡ with (large) nuclei that are pale in relation to the tumour cells.
- Edema - pale spaces between the cells - may be apparent at low power.[2]
Note:
- ‡ Large (plump) spindle cells: the nuclei have approximately the width of a resting lymphocyte.
DDx:
Images
Desmoplasia in a cecal adenocarcinoma. (WC/Nephron)
Desmoplasia in colorectal carcinoma. (WC/Nephron)
www:
See also
References
- ↑ URL: http://www.merriam-webster.com/medical/desmoplasia. Accessed on: 2 May 2013.
- ↑ Weedman Molavi, Diana (2008). The Practice of Surgical Pathology: A Beginner's Guide to the Diagnostic Process (1st ed.). Springer. pp. 15. ISBN 978-0387744858.
- ↑ URL: http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/homepage.htm. Accessed on: 2 May 2013.