Difference between revisions of "Endometrium with changes due to exogenous hormones"

Endometrium with changes due to exogenous hormones
	External resources
EHVSC	10170

Endometrium with changes due to exogenous hormones
	Diagnosis in short
	; Endometrium with changes due to exogenous hormones. H&E stain.
LM	inactive glands (round/ovoid glands, simple cuboidal epithelium, no mitoses), decidualized stroma (nucleus central, eosinophilic cytoplasm, well-defined cell borders)
LM DDx	endometrial hyperplasia with secretory changes, secretory phase endometrium
Site	endometrium
Clinical history	exogenous hormones (oral contraceptive pill or hormone releasing intrauterine device)
Prognosis	benign

Latest revision as of 14:47, 27 November 2015

Endometrium with changes due to exogenous hormones is relatively common in endometrial samples.

Endometrial changes of oral contraception, oral contraceptive effect, OCP endometrium, and endometrium with hormonal changes redirect here.

The oral contraceptive pill is dealt with in the article oral contraceptive pill.

General

Very common.
Most pills are a mix of progesterone and estrogen.
- The progesterone is what generates the characteristic appearance -- that is similar to pregnancy.
Same appearance is seen with a levonorgestrel-releasing intrauterine device, e.g. Mirena.

Microscopic

Features:^[1]

Inactive glands (round/ovoid glands, simple cuboidal epithelium, no mitoses).
Stroma decidualized -- mnemonic NEW:
- Nucleus central.
- Eosinophilic cytoplasm.
- Well-defined cell borders.

DDx:

Endometrial hyperplasia with secretory changes - proliferative activity.
Secretory phase endometrium - glandular changes of the secretory phase (cytoplasmic vacuolization), secretions in the glands.

Image

Endometrium of woman on an OCP. (WC/Nephron)
Endometrium of woman on an OCP. (WC/Nephron)
Endometrium of woman on an OCP. (WC/Nephron)

Hormone effect - intermed. mag. (WC)
Hormone effect - high mag. (WC)
Hormone effect - very high mag. (WC)

Sign out

Endometrium, Curettage:
- Endometrium with nonproliferative endometrial glands and stromal decidualization,
  consistent with exogenous hormones.

Block letters

ENDOMETRIUM, BIOPSY:
- NON-PROLIFERATIVE ENDOMETRIAL GLANDS WITH STROMAL DECIDUALIZATION, CONSISTENT 
  WITH EXOGENOUS HORMONES.

OCP effect and shedding endometrium

ENDOMETRIUM, ASPIRATION:
- ENDOMETRIUM WITH NONPROLIFERATIVE ENDOMETRIAL GLANDS AND
  STROMAL DECIDUALIZATION, COMPATIBLE WITH EXOGENOUS HORMONES.
- EVIDENCE OF ENDOMETRIAL SHEDDING (BALLS OF CONDENSED STROMA
  ASSOCIATED NEUTROPHILS, AND BLOOD).
- NEGATIVE FOR HYPERPLASIA AND NEGATIVE FOR MALIGNANCY.

Micro

The sections show endometrium with nonproliferative endometrial glands and stromal decidualization. The gland-to-stroma ratio is within normal limits.

References

↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1082. ISBN 0-7216-0187-1.

[Ref_PBoD1082-1] Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1082. ISBN 0-7216-0187-1.

[1]

@@ Line 1: / Line 1: @@
-#redirect [[Endometrium#Endometrial_changes_of_oral_contraception]]
+{{ Infobox diagnosis
+| Name       = {{PAGENAME}}
+| Image      = Endometrium with hormone effect -- high mag.jpg
+| Width      =
+| Caption    = Endometrium with changes due to exogenous hormones. [[H&E stain]].
+| Micro      = inactive glands (round/ovoid glands, simple cuboidal epithelium, no mitoses), decidualized stroma (nucleus central, eosinophilic cytoplasm, well-defined cell borders)
+| Subtypes   =
+| LMDDx      = [[endometrial hyperplasia with secretory changes]], [[secretory phase endometrium]]
+| Stains     =
+| IHC        =
+| EM         =
+| Molecular  =
+| IF         =
+| Gross      =
+| Grossing   =
+| Site       = [[endometrium]]
+| Assdx      =
+| Syndromes  =
+| Clinicalhx = exogenous hormones ([[oral contraceptive pill]] or hormone releasing intrauterine device)
+| Signs      =
+| Symptoms   =
+| Prevalence =
+| Bloodwork  =
+| Rads       =
+| Endoscopy  =
+| Prognosis  = benign
+| Other      =
+| ClinDDx    =
+}}
+{{ Infobox external links
+| Name           = {{PAGENAME}}
+| EHVSC          = 10170
+| pathprotocols  =
+| wikipedia      =
+| pathoutlines   =
+}}
+'''Endometrium with changes due to exogenous hormones''' is relatively common in [[endometrium|endometrial]] samples.
+'''Endometrial changes of oral contraception''', '''oral contraceptive effect''', '''OCP endometrium''', and '''endometrium with hormonal changes''' redirect here.
+The oral contraceptive pill is dealt with in the article ''[[oral contraceptive pill]]''.
+==General==
+*Very common.
+*Most pills are a mix of progesterone and estrogen.
+**The progesterone is what generates the characteristic appearance -- that is similar to [[pregnancy]].
+*Same appearance is seen with a levonorgestrel-releasing intrauterine device, e.g. ''Mirena''.
+==Microscopic==
+Features:<ref name=Ref_PBoD1082>{{Ref PBoD|1082}}</ref>
+*Inactive glands (round/ovoid glands, simple cuboidal epithelium, no mitoses).
+*Stroma decidualized -- mnemonic ''NEW'':
+**Nucleus central.
+**Eosinophilic cytoplasm.
+**Well-defined cell borders.
+DDx:
+*[[Endometrial hyperplasia with secretory changes]] - proliferative activity.
+*[[Secretory phase endometrium]] - glandular changes of the secretory phase (cytoplasmic vacuolization), secretions in the glands.
+===Image===
+<gallery>
+Image:Endometrium_ocp_use1.jpg | Endometrium of woman on an OCP. (WC/Nephron)
+Image:Endometrium_ocp_use2.jpg | Endometrium of woman on an OCP. (WC/Nephron)
+Image:Endometrium_ocp_use3.jpg | Endometrium of woman on an OCP. (WC/Nephron)
+</gallery>
+<gallery>
+Image: Endometrium with hormone effect -- intermed mag.jpg | Hormone effect - intermed. mag. (WC)
+Image: Endometrium with hormone effect -- high mag.jpg | Hormone effect - high mag. (WC)
+Image: Endometrium with hormone effect -- very high mag.jpg | Hormone effect - very high mag. (WC)
+</gallery>
+==Sign out==
+<pre>
+Endometrium, Curettage:
+- Endometrium with nonproliferative endometrial glands and stromal decidualization,
+  consistent with exogenous hormones.
+</pre>
+====Block letters====
+<pre>
+ENDOMETRIUM, BIOPSY:
+- NON-PROLIFERATIVE ENDOMETRIAL GLANDS WITH STROMAL DECIDUALIZATION, CONSISTENT
+  WITH EXOGENOUS HORMONES.
+</pre>
+===OCP effect and shedding endometrium===
+<pre>
+ENDOMETRIUM, ASPIRATION:
+- ENDOMETRIUM WITH NONPROLIFERATIVE ENDOMETRIAL GLANDS AND
+  STROMAL DECIDUALIZATION, COMPATIBLE WITH EXOGENOUS HORMONES.
+- EVIDENCE OF ENDOMETRIAL SHEDDING (BALLS OF CONDENSED STROMA
+  ASSOCIATED NEUTROPHILS, AND BLOOD).
+- NEGATIVE FOR HYPERPLASIA AND NEGATIVE FOR MALIGNANCY.
+</pre>
+===Micro===
+The sections show endometrium with nonproliferative endometrial glands and stromal
+decidualization. The gland-to-stroma ratio is within normal limits.
+==See also==
+*[[Endometrium]].
+*[[Endometrial hyperplasia with secretory changes]].
+*[[Decidualized endometrium]].
+==References==
+{{Reflist|1}}
+[[Category:Diagnosis]]
+[[Category:Endometrium]]