Difference between revisions of "DNA repair genes"
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!Tumours | !Tumours | ||
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| BRCA1 | | [[BRCA1]] | ||
| familial breast and ovarian cancer | | familial breast and ovarian cancer | ||
| breast, ovary, prostate, pancreas, | | breast, ovary, prostate, pancreas, male breast, fallopian tube | ||
|- | |- | ||
| BRCA2 | | [[BRCA2]] | ||
| familial breast and ovarian cancer 2 | | familial breast and ovarian cancer 2 | ||
| breast, ovary, prostate, pancreas, stomach, | | breast, ovary, prostate, pancreas, stomach, male breast, melanoma, stomach, biliary, pharynx | ||
|- | |- | ||
| MSH2 | | MSH2 | ||
| [[Lynch syndrome]] | | [[Lynch syndrome]] | ||
| [[colorectal carcinoma]], [[endometrial carcinoma]], gastric, pancreas, urothelial, biliary | | [[colorectal carcinoma|colorectal]], [[endometrial carcinoma|endometrial]], [[stomach cancer|gastric]], pancreas, urothelial, biliary | ||
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Latest revision as of 15:53, 27 May 2014
DNA repair genes fix broken DNA. Failure of DNA repair can lead to cancer.
There is a long and growing list of DNA repair genes.[1]
Examples
| Gene | Syndrome | Tumours |
|---|---|---|
| BRCA1 | familial breast and ovarian cancer | breast, ovary, prostate, pancreas, male breast, fallopian tube |
| BRCA2 | familial breast and ovarian cancer 2 | breast, ovary, prostate, pancreas, stomach, male breast, melanoma, stomach, biliary, pharynx |
| MSH2 | Lynch syndrome | colorectal, endometrial, gastric, pancreas, urothelial, biliary |
References
- ↑ Wood, RD.; Mitchell, M.; Sgouros, J.; Lindahl, T. (Feb 2001). "Human DNA repair genes.". Science 291 (5507): 1284-9. doi:10.1126/science.1056154. PMID 11181991.