Difference between revisions of "Rhinoscleroma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Rhinoscleroma_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Rhinoscleroma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = macrophages with clear-to-foamy cytoplasm, lymphocytes, plasma cells | |||
| Subtypes = | |||
| LMDDx = [[Rosai-Dorfman disease]] | |||
| Stains = [[Warthin-Starry stain]] +ve (rod-shaped organisms) | |||
| IHC = CD68 +ve, S100 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[head and neck pathology|head and neck]] - usu. nose | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = nasal deformation (late) | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Rhinoscleroma''' is a rare infectious condition of the [[head and neck pathology|head and neck]]. | |||
==General== | |||
*Caused by ''Klebsiella rhinoscleromatis''. | |||
*Nose involved +95% of the time.<ref name=pmid17359555>{{Cite journal | last1 = Chan | first1 = TV. | last2 = Spiegel | first2 = JH. | title = Klebsiella rhinoscleromatis of the membranous nasal septum. | journal = J Laryngol Otol | volume = 121 | issue = 10 | pages = 998-1002 | month = Oct | year = 2007 | doi = 10.1017/S0022215107006421 | PMID = 17359555 }}</ref> | |||
==Gross== | |||
*Nasal mass - may be deforming. | |||
Image: | |||
*[http://commons.wikimedia.org/wiki/File:Wolkowitsch1.jpg Rhinoscleroma (WC)]. | |||
==Microscopic== | |||
Features:<ref>URL: [http://www.brown.edu/Courses/Digital_Path/systemic_path/hn/rhinoscleroma2.html http://www.brown.edu/Courses/Digital_Path/systemic_path/hn/rhinoscleroma2.html]. Accessed on: 18 January 2012.</ref> | |||
*Macrophages - clear-to-foamy cytoplasm. | |||
*Lymphocytes. | |||
*Plasma cells. | |||
DDx: | |||
*[[Rosai-Dorfman disease]] - usu. has [[emperipolesis]].<ref name=pmid21938169>{{cite journal |author=Iyer VK, Handa KK, Sharma MC |title=Variable extent of emperipolesis in the evolution of Rosai Dorfman disease: Diagnostic and pathogenetic implications |journal=J Cytol |volume=26 |issue=3 |pages=111–6 |year=2009 |month=July |pmid=21938169 |pmc=3168012 |doi=10.4103/0970-9371.59398 |url=}}</ref> | |||
===Images=== | |||
<gallery> | |||
Image:Rhinoscleroma_-_intermed_mag.jpg | Rhinoscleroma - intermed. mag. (WC) | |||
Image:Rhinoscleroma_-_high_mag.jpg | Rhinoscleroma - high mag. (WC) | |||
Image:Rhinoscleroma_-_very_high_mag.jpg | Rhinoscleroma - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://www.brown.edu/Courses/Digital_Path/systemic_path/hn/rhinoscleroma2.html Rhinoscleroma (brown.edu)]. | |||
*[http://www.jameswpattersonmd.com/images/pages/rhinoscleroma_mic324.jpg Rhinoscleroma (jameswpattersonmd.com)].<ref>URL: [http://www.jameswpattersonmd.com/case_studies/index.cfm?CFID=387434 http://www.jameswpattersonmd.com/case_studies/index.cfm?CFID=387434]. Accessed on: 21 February 2012.</ref> | |||
==Stains== | |||
*Warthin-Starry stain +ve (rod-shaped organisms). | |||
*[[Dieterle stain]] +ve (rod-shaped organisms). | |||
==IHC== | |||
*S100 -ve.<ref name=pmid19646302>{{cite journal |author=Ilie M, Guevara N, Castillo L, Hofman P |title=Polypoid intranasal mass caused by Rosai-Dorfman disease: a diagnostic pitfall |journal=J Laryngol Otol |volume=124 |issue=3 |pages=345–8 |year=2010 |month=March |pmid=19646302 |doi=10.1017/S0022215109990818 |url=}}</ref> | |||
==See also== | |||
*[[Head and neck pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Head and neck pathology]] | |||
Latest revision as of 03:03, 7 July 2014
| Rhinoscleroma | |
|---|---|
| Diagnosis in short | |
 Rhinoscleroma. H&E stain. | |
|
| |
| LM | macrophages with clear-to-foamy cytoplasm, lymphocytes, plasma cells |
| LM DDx | Rosai-Dorfman disease |
| Stains | Warthin-Starry stain +ve (rod-shaped organisms) |
| IHC | CD68 +ve, S100 -ve |
| Site | head and neck - usu. nose |
|
| |
| Signs | nasal deformation (late) |
| Prevalence | rare |
Rhinoscleroma is a rare infectious condition of the head and neck.
General
- Caused by Klebsiella rhinoscleromatis.
- Nose involved +95% of the time.[1]
Gross
- Nasal mass - may be deforming.
Image:
Microscopic
Features:[2]
- Macrophages - clear-to-foamy cytoplasm.
- Lymphocytes.
- Plasma cells.
DDx:
- Rosai-Dorfman disease - usu. has emperipolesis.[3]
Images
Rhinoscleroma - intermed. mag. (WC)
Rhinoscleroma - high mag. (WC)
Rhinoscleroma - very high mag. (WC)
www:
Stains
- Warthin-Starry stain +ve (rod-shaped organisms).
- Dieterle stain +ve (rod-shaped organisms).
IHC
- S100 -ve.[5]
See also
References
- ↑ Chan, TV.; Spiegel, JH. (Oct 2007). "Klebsiella rhinoscleromatis of the membranous nasal septum.". J Laryngol Otol 121 (10): 998-1002. doi:10.1017/S0022215107006421. PMID 17359555.
- ↑ URL: http://www.brown.edu/Courses/Digital_Path/systemic_path/hn/rhinoscleroma2.html. Accessed on: 18 January 2012.
- ↑ Iyer VK, Handa KK, Sharma MC (July 2009). "Variable extent of emperipolesis in the evolution of Rosai Dorfman disease: Diagnostic and pathogenetic implications". J Cytol 26 (3): 111–6. doi:10.4103/0970-9371.59398. PMC 3168012. PMID 21938169. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168012/.
- ↑ URL: http://www.jameswpattersonmd.com/case_studies/index.cfm?CFID=387434. Accessed on: 21 February 2012.
- ↑ Ilie M, Guevara N, Castillo L, Hofman P (March 2010). "Polypoid intranasal mass caused by Rosai-Dorfman disease: a diagnostic pitfall". J Laryngol Otol 124 (3): 345–8. doi:10.1017/S0022215109990818. PMID 19646302.