Difference between revisions of "Rheumatoid arthritis"

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'''Rheumatoid arthritis''', commonly abbreviated '''RA''', is an autoimmune disorder.
'''Rheumatoid arthritis''', commonly abbreviated '''RA''', is an autoimmune disorder.


==Skin==
=Skin=
==Rheumatoid neutrophilic dermatitis==
===General===
===General===
*May manifest as ''rheumatoid neutrophilic dermatitis'' - super rare.<ref name=pmid9197831>{{Cite journal  | last1 = Mashek | first1 = HA. | last2 = Pham | first2 = CT. | last3 = Helm | first3 = TN. | last4 = Klaus | first4 = M. | title = Rheumatoid neutrophilic dermatitis. | journal = Arch Dermatol | volume = 133 | issue = 6 | pages = 757-60 | month = Jun | year = 1997 | doi =  | PMID = 9197831 }}</ref>
*Case report rare manifestation of rheumatoid arthritis.<ref name=pmid9197831>{{Cite journal  | last1 = Mashek | first1 = HA. | last2 = Pham | first2 = CT. | last3 = Helm | first3 = TN. | last4 = Klaus | first4 = M. | title = Rheumatoid neutrophilic dermatitis. | journal = Arch Dermatol | volume = 133 | issue = 6 | pages = 757-60 | month = Jun | year = 1997 | doi =  | PMID = 9197831 }}</ref>


===Microscopic===
===Microscopic===
Features:
Features:
*Nodular and diffuse pattern.
*Nodular and diffuse pattern.
*[[Neutrophil]]s.
*[[Neutrophil]]s - perivascular (without vessel wall injury).<ref name=pmid9197831/>
 
DDx:
*[[Vasculitis]].
 
=Joints=
{{Main|Joints}}
==Rheumatic joint disease==
*[[AKA]] ''joint with rheumatic disease''.
===General===
Clinical:
*Tumour - swelling.
*Rubor - redness.
*Calor - heat.
*Dolor - pain.
 
===Gross===
Features:
*Pannus<ref name=Ref_Lester223>{{Ref Lester|223}}</ref> - fibrovascular tissue or granulation tissue.
*Irregular surface - synovial hyperplasia.
*Subchondral cysts - involve the entire femoral head (late stage of disease).<ref name=pmid404905/>
 
Note:
*[[Osteoarthritis]] subchondral cysts are associated with cartilage loss.<ref name=pmid404905>{{Cite journal  | last1 = Resnick | first1 = D. | last2 = Niwayama | first2 = G. | last3 = Coutts | first3 = RD. | title = Subchondral cysts (geodes) in arthritic disorders: pathologic and radiographic appearance of the hip joint. | journal = AJR Am J Roentgenol | volume = 128 | issue = 5 | pages = 799-806 | month = May | year = 1977 | doi =  | PMID = 404905 }}</ref>
 
Image:
*[http://www.medpath.info/MainContent/Skeletal/732.GIF Gross image of RA (medpath.info)].<ref name=medpath>URL: [http://www.medpath.info/MainContent/Skeletal/Joint_02.html http://www.medpath.info/MainContent/Skeletal/Joint_02.html]. Accessed on: 10 November 2012.</ref>
*[http://www.tumorlibrary.com/case/detail.jsp?image_id=3907 RA mimicking chondrosarcoma (tumorlibrary.com)].


==Joints==
===Microscopic===
===Microscopic===
Features:
Features:<ref name=Ref_WMSP660>{{Ref WMSP|660}}</ref>
*Chronic inflammation (e.g. lymphocytes).
*Chronic inflammation, esp. lymphocytes.
**+/-Lymphoid follicles.
*Synovial hyperplasia - with papillary ''or'' polypoid architecture.
**Synoviocytes may show binucleation and mild atypia.
*+/-Fibrin.
*+/-Bone.
*+/-Cartilage.
 
Note:
*Changes are non-specific - DDx includes other rheumatic diseases ([[systemic lupus erythematosus]], [[psoriatic arthritis]]).
 
DDx:
*Infected joint.


Images:
Images:
*[http://library.med.utah.edu/WebPath/jpeg3/BONE044.jpg RA (med.utah.edu)].<ref>URL: [http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/msfrm.html http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/msfrm.html]. Accessed on: 5 December 2010.</ref>
*[http://library.med.utah.edu/WebPath/jpeg3/BONE044.jpg RA (med.utah.edu)].<ref>URL: [http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/msfrm.html http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/msfrm.html]. Accessed on: 5 December 2010.</ref>
*[http://www.nature.com/nature/journal/v423/n6937/fig_tab/nature01661_F1.html Rheumatoid arthritis (nature.com)].
*[http://www.medpath.info/MainContent/Skeletal/3100.GIF Synovial inflammation (medpath.info)].<ref name=medpath/>
*[http://www.medpath.info/MainContent/Skeletal/3109.GIF Hyperplastic synovitis (medpath.info)].<ref name=medpath/>
*[http://ard.bmj.com/content/58/3.cover-expansion RA cartilage loss (bmj.com)].
===Sign out===
====Femoral head====
<pre>
FEMORAL HEAD, LEFT, HIP ARTHROPLASTY:
- CHRONIC SYNOVITIS WITH SYNOVIAL HYPERPLASIA AND LOSS OF CARTILAGE.
- BONE WITHOUT APPARENT PATHOLOGY.
- SEE COMMENT.
COMMENT:
The findings are compatible with rheumatoid arthritis.
</pre>
====Hand====
<pre>
Right Hand - Metacarpal Heads of Index Finger, Middle Finger and Ring Finger, Excision:
- Benign bone and cartilage focally associated with fibrous tissue and erosions.
- Fatty marrow space.
- NEGATIVE for significant inflammation.
- NEGATIVE for malignancy.
Comment:
The history of rheumatoid arthritis and deformities is noted.
</pre>
<pre>
SYNOVIUM, LEFT HAND, EXCISION:
- SYNOVIAL HYPERPLASIA.
- CHRONIC AND FOCAL ACUTE SYNOVITIS.
- FIBRINOUS EXUDATE.
- GRANULATION TISSUE AND HEMOSIDERIN-LADEN MACROPHAGES.
- SEE COMMENT.
COMMENT:
The findings are compatible with rheumatoid arthritis.
</pre>


==Rheumatoid nodule==
====Knee====
===General===
<pre>
*Usually only in seropositive cases.<ref name=Ref_DCHH299>{{Ref DCHH|299}}</ref>
KNEE - BONE AND SOFT TISSUE, RIGHT, KNEE ARTHROPLASTY:
- CHRONIC SYNOVITIS WITH SYNOVIAL HYPERPLASIA AND LOSS OF CARTILAGE.
- BONE WITHOUT APPARENT PATHOLOGY.
 
COMMENT:
The findings are compatible with rheumatoid arthritis.
</pre>
 
<pre>
KNEE - BONE AND SOFT TISSUE, LEFT, KNEE ARTHROPLASTY:
- DEGENERATIVE JOINT DISEASE WITH CHRONIC SYNOVITIS AND SYNOVIAL HYPERPLASIA.
- BONE WITHOUT APPARENT PATHOLOGY.


===Microscopic===
COMMENT:
Features:<ref name=Ref_DCHH299>{{Ref DCHH|299}}</ref>
The findings are compatible with rheumatoid arthritis.
*Necrotic collagen bundles with mucin surrounded by:
</pre>
**Palisading [[granuloma]].
*+/-Eosinophils.


Notes:
==Rheumatoid nodule==
*Histomorphologically identical to ''[[Granuloma annulare]]''. (???)
{{Main|Rheumatoid nodule}}
{{Main|Rheumatoid lung nodule}}


Images:
=Pleural disease=
*[http://granuloma.homestead.com/rheumatoid_nod_S89-2617-1.jpg Rheumatoid nodule (granuloma.homestead.com)].<ref name=ghc>URL: [http://granuloma.homestead.com/palisading.html http://granuloma.homestead.com/palisading.html]. Accessed on: 1 November 2010.</ref>
:''See [[Rheumatoid pleuritis]]''.
*[http://granuloma.homestead.com/rheumatoid_nod_S89-2617-5.jpg Rheumatoid nodule (granuloma.homestead.com)].<ref name=ghc>URL: [http://granuloma.homestead.com/palisading.html http://granuloma.homestead.com/palisading.html]. Accessed on: 1 November 2010.</ref>
*[http://library.med.utah.edu/WebPath/jpeg3/BONE045.jpg Rheumatoid nodule (utah.edu)].<ref>URL: [http://www.pathguy.com/lectures/joints.htm http://www.pathguy.com/lectures/joints.htm]. Accessed on: 1 November 2010.</ref>


==Lung disease==
=Lung disease=
:''See [[Medical lung disease]]''.
:''See [[Medical lung disease]]''.
RA may involve the [[lung]].
RA may involve the [[lung]].


=Miscellaneous=
==Amyloidosis==
==Amyloidosis==
:''See [[Amyloidosis]]''.
:''See [[Amyloidosis]]''.
Line 50: Line 138:
*Neutropenia.
*Neutropenia.


Felty syndrome is assoc. with ''large granular lymphocytic leukemia''.<ref name=Ref_PCPBoD8_328>{{Ref PCPBoD8|328}}</ref>
Felty syndrome is associated with ''[[T-cell large granular lymphocytic leukemia|large granular lymphocytic leukemia]]''.<ref name=Ref_PCPBoD8_328>{{Ref PCPBoD8|328}}</ref><ref name=pmid21546829>{{Cite journal  | last1 = Liu | first1 = X. | last2 = Loughran | first2 = TP. | title = The spectrum of large granular lymphocyte leukemia and Felty's syndrome. | journal = Curr Opin Hematol | volume = 18 | issue = 4 | pages = 254-9 | month = Jul | year = 2011 | doi = 10.1097/MOH.0b013e32834760fb | PMID = 21546829 }}</ref>


==See also==
=See also=
*[[Arthritis]].
*[[Arthritis]].
**[[Osteoarthritis]].
*[[Basics]].
*[[Joints]].
*[[Joints]].
*[[Basics]].


==References==
=References=
{{Reflist|2}}
{{Reflist|2}}


==External links==
=External links=
*[http://www.pathguy.com/lectures/joints.htm Joint disease (pathguy.com)].
*[http://www.pathguy.com/lectures/joints.htm Joint disease (pathguy.com)].
[[Category:Weird stuff]]
[[Category:Weird stuff]]
[[Category:Diagnosis]]

Latest revision as of 15:53, 10 April 2023

Rheumatoid arthritis, commonly abbreviated RA, is an autoimmune disorder.

Skin

Rheumatoid neutrophilic dermatitis

General

  • Case report rare manifestation of rheumatoid arthritis.[1]

Microscopic

Features:

  • Nodular and diffuse pattern.
  • Neutrophils - perivascular (without vessel wall injury).[1]

DDx:

Joints

Main article: Joints

Rheumatic joint disease

  • AKA joint with rheumatic disease.

General

Clinical:

  • Tumour - swelling.
  • Rubor - redness.
  • Calor - heat.
  • Dolor - pain.

Gross

Features:

  • Pannus[2] - fibrovascular tissue or granulation tissue.
  • Irregular surface - synovial hyperplasia.
  • Subchondral cysts - involve the entire femoral head (late stage of disease).[3]

Note:

Image:

Microscopic

Features:[5]

  • Chronic inflammation, esp. lymphocytes.
    • +/-Lymphoid follicles.
  • Synovial hyperplasia - with papillary or polypoid architecture.
    • Synoviocytes may show binucleation and mild atypia.
  • +/-Fibrin.
  • +/-Bone.
  • +/-Cartilage.

Note:

DDx:

  • Infected joint.

Images:

Sign out

Femoral head

FEMORAL HEAD, LEFT, HIP ARTHROPLASTY:
- CHRONIC SYNOVITIS WITH SYNOVIAL HYPERPLASIA AND LOSS OF CARTILAGE.
- BONE WITHOUT APPARENT PATHOLOGY.
- SEE COMMENT.

COMMENT:
The findings are compatible with rheumatoid arthritis.

Hand

Right Hand - Metacarpal Heads of Index Finger, Middle Finger and Ring Finger, Excision:
	- Benign bone and cartilage focally associated with fibrous tissue and erosions.
	- Fatty marrow space.
	- NEGATIVE for significant inflammation.
	- NEGATIVE for malignancy.

Comment:
The history of rheumatoid arthritis and deformities is noted.

SYNOVIUM, LEFT HAND, EXCISION:
- SYNOVIAL HYPERPLASIA.
- CHRONIC AND FOCAL ACUTE SYNOVITIS.
- FIBRINOUS EXUDATE.
- GRANULATION TISSUE AND HEMOSIDERIN-LADEN MACROPHAGES.
- SEE COMMENT.

COMMENT:
The findings are compatible with rheumatoid arthritis.

Knee

KNEE - BONE AND SOFT TISSUE, RIGHT, KNEE ARTHROPLASTY:
- CHRONIC SYNOVITIS WITH SYNOVIAL HYPERPLASIA AND LOSS OF CARTILAGE.
- BONE WITHOUT APPARENT PATHOLOGY.

COMMENT:
The findings are compatible with rheumatoid arthritis.

KNEE - BONE AND SOFT TISSUE, LEFT, KNEE ARTHROPLASTY:
- DEGENERATIVE JOINT DISEASE WITH CHRONIC SYNOVITIS AND SYNOVIAL HYPERPLASIA.
- BONE WITHOUT APPARENT PATHOLOGY.

COMMENT:
The findings are compatible with rheumatoid arthritis.

Rheumatoid nodule

Main article: Rheumatoid nodule
Main article: Rheumatoid lung nodule

Pleural disease

See Rheumatoid pleuritis.

Lung disease

See Medical lung disease.

RA may involve the lung.

Miscellaneous

Amyloidosis

See Amyloidosis.

Amyloidosis may be due to RA.

Felty syndrome

RA may occur in Felty syndrome -- the triad:[7]

Felty syndrome is associated with large granular lymphocytic leukemia.[7][8]

See also

References

  1. ↑ 1.0 1.1 Mashek, HA.; Pham, CT.; Helm, TN.; Klaus, M. (Jun 1997). "Rheumatoid neutrophilic dermatitis.". Arch Dermatol 133 (6): 757-60. PMID 9197831.
  2. ↑ Lester, Susan Carole (2005). Manual of Surgical Pathology (2nd ed.). Saunders. pp. 223. ISBN 978-0443066450.
  3. ↑ 3.0 3.1 Resnick, D.; Niwayama, G.; Coutts, RD. (May 1977). "Subchondral cysts (geodes) in arthritic disorders: pathologic and radiographic appearance of the hip joint.". AJR Am J Roentgenol 128 (5): 799-806. PMID 404905.
  4. ↑ 4.0 4.1 4.2 URL: http://www.medpath.info/MainContent/Skeletal/Joint_02.html. Accessed on: 10 November 2012.
  5. ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 660. ISBN 978-0781765275.
  6. ↑ URL: http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/msfrm.html. Accessed on: 5 December 2010.
  7. ↑ 7.0 7.1 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 328. ISBN 978-1416054542.
  8. ↑ Liu, X.; Loughran, TP. (Jul 2011). "The spectrum of large granular lymphocyte leukemia and Felty's syndrome.". Curr Opin Hematol 18 (4): 254-9. doi:10.1097/MOH.0b013e32834760fb. PMID 21546829.

External links

Retrieved from "https://librepathology.org/w/index.php?title=Rheumatoid_arthritis&oldid=52284"