Difference between revisions of "Langerhans cell histiocytosis"
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'''Langerhans cell histiocytosis''', abbreviated '''LCH''', is a rare genetic disorder of tissue macrophages. It broadly fits into the category of ''[[histiocytoses]]''. | '''Langerhans cell histiocytosis''', abbreviated '''LCH''', is a rare genetic disorder of tissue macrophages. It broadly fits into the category of ''[[histiocytoses]]''. It used to known as ''eosinophilic granuloma''. It has been referred to by several eponyms - '''Hand-Schüller-Christian disease''', '''Abt-Letterer-Siwe disease''', and '''histiocytosis X'''. | ||
==General== | ==General== | ||
Revision as of 01:23, 20 November 2011
Langerhans cell histiocytosis, abbreviated LCH, is a rare genetic disorder of tissue macrophages. It broadly fits into the category of histiocytoses. It used to known as eosinophilic granuloma. It has been referred to by several eponyms - Hand-Schüller-Christian disease, Abt-Letterer-Siwe disease, and histiocytosis X.
General
- Looks like pulmonary Langerhans cell histiocytosis - see medical lung diseases.
Microscopic
Features:
- Langerhans cells histiocytes - key feature.
- Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm.
- Nucleus may look like a "coffee bean", i.e. have nuclear grooves (similar to those in papillary thyroid carcinoma) -- appearance dependent on the rotation of the nucleus.[1]
- Chromatin pattern: fine granular, light gray.
- Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm.
- +/-Eosinophils - often prominent.
Images:
DDx:
- Kimura disease - eosinophilia.
- See lymph node pathology.
IHC
- CD1a +ve.
- S100 +ve.
Electron microscopy
See also
References
- ↑ BN. 15 March 2011.