Difference between revisions of "Intranodal palisaded myofibroblastoma"
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==General== | ==General== | ||
*Rare. | *Rare ~ 55 case in world literature.<ref name=pmid21718465/> | ||
Demographics: | |||
*Male:female = 2:1. | *Male:female = 2:1. | ||
*Adults - middle age. | *Adults - middle age. | ||
*Treatment: | |||
Location: | |||
*Usually inguinal lymph node. | |||
*Reported in retroperitoneum.<ref name=pmid21718465>{{Cite journal | last1 = Sagar | first1 = J. | last2 = Vargiamidou | first2 = A. | last3 = Manikkapurath | first3 = H. | title = Intranodal palisaded myofibroblastoma originating from retroperitoneum: an unusual origin. | journal = BMC Clin Pathol | volume = 11 | issue = | pages = 7 | month = | year = 2011 | doi = 10.1186/1472-6890-11-7 | PMID = 21718465 | PMC = 3146916 }}</ref> | |||
Treatment: | |||
*Simple excision; rare recurrences have been reported.<ref name=pmid10235504>{{Cite journal | last1 = Creager | first1 = AJ. | last2 = Garwacki | first2 = CP. | title = Recurrent intranodal palisaded myofibroblastoma with metaplastic bone formation. | journal = Arch Pathol Lab Med | volume = 123 | issue = 5 | pages = 433-6 | month = May | year = 1999 | doi = 10.1043/0003-9985(1999)1230433:RIPMWM2.0.CO;2 | PMID = 10235504 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
| Line 28: | Line 36: | ||
**[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802163636511 IPM (surgicalpathologyatlas.com)]. | **[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802163636511 IPM (surgicalpathologyatlas.com)]. | ||
**[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC496726/figure/F4/ Amianthoid fibers (nih.gov)].<ref name=pmid1918406>{{Cite journal | last1 = Bigotti | first1 = G. | last2 = Coli | first2 = A. | last3 = Mottolese | first3 = M. | last4 = Di Filippo | first4 = F. | title = Selective location of palisaded myofibroblastoma with amianthoid fibres. | journal = J Clin Pathol | volume = 44 | issue = 9 | pages = 761-4 | month = Sep | year = 1991 | doi = | PMID = 1918406 }}</ref> | **[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC496726/figure/F4/ Amianthoid fibers (nih.gov)].<ref name=pmid1918406>{{Cite journal | last1 = Bigotti | first1 = G. | last2 = Coli | first2 = A. | last3 = Mottolese | first3 = M. | last4 = Di Filippo | first4 = F. | title = Selective location of palisaded myofibroblastoma with amianthoid fibres. | journal = J Clin Pathol | volume = 44 | issue = 9 | pages = 761-4 | month = Sep | year = 1991 | doi = | PMID = 1918406 }}</ref> | ||
**[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146916/figure/F4/ Amianthoid fibers (nih.gov)].<ref name=pmid21718465/> | |||
*[[WC]]: | *[[WC]]: | ||
**[http://commons.wikimedia.org/wiki/File:Intranodal_palisaded_myofibroblastoma_-_intermed_mag.jpg IPM - intermed. mag. (WC)]. | **[http://commons.wikimedia.org/wiki/File:Intranodal_palisaded_myofibroblastoma_-_intermed_mag.jpg IPM - intermed. mag. (WC)]. | ||
Revision as of 02:35, 12 October 2011
Intranodal palisaded myofibroblastoma, abbreviated IPM, is a rare tumour that classically presents as an inguinal mass.[1]
General
- Rare ~ 55 case in world literature.[2]
Demographics:
- Male:female = 2:1.
- Adults - middle age.
Location:
- Usually inguinal lymph node.
- Reported in retroperitoneum.[2]
Treatment:
- Simple excision; rare recurrences have been reported.[3]
Microscopic
Features:
- Rim of peripheral lymphoid tissue.
- Remnant of lymph node.
- Spindle cells with nuclear palisading - key feature.
- RBC extravasation/hemorrhage.
- Amianthoid fibers - blood vessel surrounded by collagen with (fine) peripheral spokes.[4]
- Intracellular and extracellular fuchsinophilic bodies.
- Smooth muscle actin +ve.
DDx:
Notes:
- Fuchsinophilic = affinity for the acid dye fuchsin.[5]
- Image: Fuchsinophilic material (flickr.com) - red.
Images:
- www:
- WC:
IHC
- SMA +ve.
- Cyclin D1 +ve.
Other:
- S100 -ve
- Excludes schwannoma.
- GFAP -ve.
- CD34 -ve.
- Desmin -ve
- Ki-67 - low.
See also
References
- ↑ Nguyen, T.; Eltorky, MA. (Feb 2007). "Intranodal palisaded myofibroblastoma.". Arch Pathol Lab Med 131 (2): 306-10. doi:10.1043/1543-2165(2007)131[306:IPM]2.0.CO;2. PMID 17284119.
- ↑ 2.0 2.1 2.2 Sagar, J.; Vargiamidou, A.; Manikkapurath, H. (2011). "Intranodal palisaded myofibroblastoma originating from retroperitoneum: an unusual origin.". BMC Clin Pathol 11: 7. doi:10.1186/1472-6890-11-7. PMC 3146916. PMID 21718465. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146916/.
- ↑ Creager, AJ.; Garwacki, CP. (May 1999). "Recurrent intranodal palisaded myofibroblastoma with metaplastic bone formation.". Arch Pathol Lab Med 123 (5): 433-6. doi:10.1043/0003-9985(1999)1230433:RIPMWM2.0.CO;2. PMID 10235504.
- ↑ 4.0 4.1 Bigotti, G.; Coli, A.; Mottolese, M.; Di Filippo, F. (Sep 1991). "Selective location of palisaded myofibroblastoma with amianthoid fibres.". J Clin Pathol 44 (9): 761-4. PMID 1918406.
- ↑ URL: http://www.merriam-webster.com/medical/fuchsinophilic. Accessed on: 3 October 2011.