Difference between revisions of "ALK translocation renal cell carcinoma"

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'''ALK translocation renal cell carcinoma''' is a proposed entity within the ''[[Vancouver classification|Vancouver modification of the 2004 WHO classification of renal neoplasia]]''.<ref name=pmid24025519>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref>
#redirect [[ALK-rearranged renal cell carcinoma]]
 
==General==
*Extremely rare.
*May be related to ''[[renal medullary carcinoma]]'' which is reported to have an ALK rearrangement - t(2;10)(p23;q22).<ref name=pmid21213368>{{Cite journal  | last1 = Mariño-Enríquez | first1 = A. | last2 = Ou | first2 = WB. | last3 = Weldon | first3 = CB. | last4 = Fletcher | first4 = JA. | last5 = Pérez-Atayde | first5 = AR. | title = ALK rearrangement in sickle cell trait-associated renal medullary carcinoma. | journal = Genes Chromosomes Cancer | volume = 50 | issue = 3 | pages = 146-53 | month = Mar | year = 2011 | doi = 10.1002/gcc.20839 | PMID = 21213368 }}</ref>
 
==Microscopic==
Features:
*Mix of morphologies - rhabdoid, sarcomatoid, "[[unclassified renal cell carcinoma]]".
 
DDx:
*[[Unclassified renal cell carcinoma]]
*[[Renal medullary carcinoma]].
 
==IHC==
*ALK +ve.
*[[SMARCB1]] -ve.
 
==See also==
*[[Vancouver classification]].
*[[Kidney tumours]].
*[[Lung carcinoma with ALK rearrangement]].
 
==References==
{{Reflist|1}}
 
[[Category:Kidney tumours]]

Latest revision as of 21:47, 26 September 2025

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