Difference between revisions of "Well-differentiated papillary mesothelial tumour"

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| Image      = Well-differentiated_papillary_mesothelioma_--_intermed._mag.jpg
| Image      = Well-differentiated_papillary_mesothelioma_--_intermed._mag.jpg
| Width      =
| Width      =
| Caption    = Well-differentiated papillary mesothelioma. [[H&E stain]].
| Caption    = Well-differentiated papillary mesothelial tumour. [[H&E stain]].
| Synonyms  = benign papillary mesothelioma
| Synonyms  = well-differentiated papillary mesothelioma (obsolete term), benign papillary mesothelioma (obsolete term)
| Micro      = papillary structures with thick fibrous cores and simple cuboidal epithelium, lacks cytologic atypia
| Micro      = papillary structures with thick fibrous cores and simple cuboidal epithelium, lacks cytologic atypia
| Subtypes  =
| Subtypes  =
| LMDDx      = [[ovarian serous carcinoma]], [[serous borderline tumour of the ovary]], [[malignant mesothelioma]]
| LMDDx      = [[ovarian serous carcinoma]], [[serous borderline tumour of the ovary]], [[malignant mesothelioma]] especially ''papillary mesothelioma in situ''
| Stains    =
| Stains    =
| IHC        = calretinin +ve, CK5/6 +ve
| IHC        = calretinin +ve, CK5/6 +ve, BAP1 retained (normal)
| EM        =
| EM        =
| Molecular  =
| Molecular  =
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| Rads      =
| Rads      =
| Endoscopy  =
| Endoscopy  =
| Prognosis  = typical indolent
| Prognosis  = typically indolent
| Other      =
| Other      =
| ClinDDx    = [[tuberculosis]], [[carcinoma|carcinomatosis]], [[primary peritoneal serous carcinoma]]
| ClinDDx    = [[tuberculosis]], [[carcinoma|carcinomatosis]], [[primary peritoneal serous carcinoma]], others
| Tx        =
| Tx        =
}}
}}
'''Well-differentiated papillary mesothelioma''', abbreviated '''WDPM''', is a rare type of [[mesothelioma]] that typically has an indolent behaviour.<ref name=pmid11688466>{{Cite journal | last1 = Butnor | first1 = KJ. | last2 = Sporn | first2 = TA. | last3 = Hammar | first3 = SP. | last4 = Roggli | first4 = VL. | title = Well-differentiated papillary mesothelioma. | journal = Am J Surg Pathol | volume = 25 | issue = 10 | pages = 1304-9 | month = Oct | year = 2001 | doi = | PMID = 11688466 }}</ref>
'''Well-differentiated papillary mesothelial tumour''', abbreviated '''WDPMT''', is a rare benign mesothelial tumour.<ref name=pmid35440764>{{cite journal |authors=Churg A, Galateau-Salle F |title=Well differentiated papillary mesothelial tumor: a new name and new problems |journal=Mod Pathol |volume=35 |issue=10 |pages=1327–1333 |date=October 2022 |pmid=35440764 |doi=10.1038/s41379-022-01082-y |url=}}</ref>


It is also known as '''benign papillary mesothelioma'''. It should '''not''' be confused with ''[[malignant mesothelioma]]'' or ''[[benign multicystic mesothelioma]]''.
It was previously known as ''well-differentiated papillary mesothelioma'', abbreviated ''WDPM''.<ref name=pmid35440764/><ref name=pmid11688466>{{Cite journal  | last1 = Butnor | first1 = KJ. | last2 = Sporn | first2 = TA. | last3 = Hammar | first3 = SP. | last4 = Roggli | first4 = VL. | title = Well-differentiated papillary mesothelioma. | journal = Am J Surg Pathol | volume = 25 | issue = 10 | pages = 1304-9 | month = Oct | year = 2001 | doi =  | PMID = 11688466 }}</ref>  It was also known as ''benign papillary mesothelioma''. This entity should ''not'' be confused with ''[[malignant mesothelioma]]'' and ''[[benign multicystic mesothelioma]]''.


==General==
==General==
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*[[Ovarian serous carcinoma]].
*[[Ovarian serous carcinoma]].
*[[Serous borderline tumour of the ovary]].
*[[Serous borderline tumour of the ovary]].
*[[Malignant mesothelioma]].
*[[Malignant mesothelioma]] - especially [[papillary mesothelioma in situ]].
**''Papillary mesothelioma in situ'' is morphologically identical.<ref name=pmid35440764/>


===Images===
===Images===
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*Calretinin +ve.
*Calretinin +ve.
*CK5/6 +ve.
*CK5/6 +ve.
*BAP1 retained (normal).<ref name=pmid35440764/>


==See also==
==See also==
*[[Peritoneum]].
*[[Peritoneum]].
*[[Malignant mesothelioma]].
*[[Malignant mesothelioma]].
*[[Mesothelioma]].


==References==
==References==

Latest revision as of 02:36, 20 August 2025

Well-differentiated papillary mesothelial tumour
Diagnosis in short

Well-differentiated papillary mesothelial tumour. H&E stain.
Synonyms well-differentiated papillary mesothelioma (obsolete term), benign papillary mesothelioma (obsolete term)
LM papillary structures with thick fibrous cores and simple cuboidal epithelium, lacks cytologic atypia
LM DDx ovarian serous carcinoma, serous borderline tumour of the ovary, malignant mesothelioma especially papillary mesothelioma in situ
IHC calretinin +ve, CK5/6 +ve, BAP1 retained (normal)
Site pleura, peritoneum, tunica vaginalis (testis)
Prevalence rare
Prognosis typically indolent
Clin. DDx tuberculosis, carcinomatosis, primary peritoneal serous carcinoma, others

Well-differentiated papillary mesothelial tumour, abbreviated WDPMT, is a rare benign mesothelial tumour.[1]

It was previously known as well-differentiated papillary mesothelioma, abbreviated WDPM.[1][2] It was also known as benign papillary mesothelioma. This entity should not be confused with malignant mesothelioma and benign multicystic mesothelioma.

General

  • Benign.
    • Some say it is borderline.[3]
  • Classically women of reproductive age.[4]
  • Reported in tunica vaginalis of the testis.[5]
  • Associated with asbestos exposure.[2]

Gross

Typical features for peritoneum:

  • Multiple peritoneal nodules.
  • Ascites.

DDx (peritoneum):[4]

Microscopic

Features:

  • Papillary structures with:
    • Thick fibrous cores.
    • Simple cuboidal epithelium.
      • Small nucleoli.

Note:

  • Lack cytologic atypia.

DDx:[6]

Images

  • WDPM - low mag.

  • WDPM - intermed. mag.

  • WDPM - high mag.

  • WDPM - very high mag.

  • WDPM - low mag.

  • WDPM - intermed. mag.

  • WDPM - high mag.

www:

IHC

Features:[7]

  • Calretinin +ve.
  • CK5/6 +ve.
  • BAP1 retained (normal).[1]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 Churg A, Galateau-Salle F (October 2022). "Well differentiated papillary mesothelial tumor: a new name and new problems". Mod Pathol 35 (10): 1327–1333. doi:10.1038/s41379-022-01082-y. PMID 35440764.
  2. ↑ 2.0 2.1 Butnor, KJ.; Sporn, TA.; Hammar, SP.; Roggli, VL. (Oct 2001). "Well-differentiated papillary mesothelioma.". Am J Surg Pathol 25 (10): 1304-9. PMID 11688466.
  3. ↑ Bürrig, KF.; Pfitzer, P.; Hort, W. (1990). "Well-differentiated papillary mesothelioma of the peritoneum: a borderline mesothelioma. Report of two cases and review of literature.". Virchows Arch A Pathol Anat Histopathol 417 (5): 443-7. PMID 2122588.
  4. ↑ 4.0 4.1 Park, JY.; Kim, KW.; Kwon, HJ.; Park, MS.; Kwon, GY.; Jun, SY.; Yu, ES. (Sep 2008). "Peritoneal mesotheliomas: clinicopathologic features, CT findings, and differential diagnosis.". AJR Am J Roentgenol 191 (3): 814-25. doi:10.2214/AJR.07.3628. PMID 18716115.
  5. ↑ Chetty, R. (Nov 1992). "Well differentiated (benign) papillary mesothelioma of the tunica vaginalis.". J Clin Pathol 45 (11): 1029-30. PMID 1452778.
  6. ↑ Truong, LD.; Maccato, ML.; Awalt, H.; Cagle, PT.; Schwartz, MR.; Kaplan, AL. (Jan 1990). "Serous surface carcinoma of the peritoneum: a clinicopathologic study of 22 cases.". Hum Pathol 21 (1): 99-110. PMID 1688545.
  7. ↑ Malpica, A.; Sant'Ambrogio, S.; Deavers, MT.; Silva, EG. (Jan 2012). "Well-differentiated papillary mesothelioma of the female peritoneum: a clinicopathologic study of 26 cases.". Am J Surg Pathol 36 (1): 117-27. doi:10.1097/PAS.0b013e3182354a79. PMID 22024662.
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