Difference between revisions of "ALK translocation renal cell carcinoma"
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| Line 7: | Line 7: | ||
| Micro = mixed morphology, +/-papillae, +/-myxoid change | | Micro = mixed morphology, +/-papillae, +/-myxoid change | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[papillary renal cell carcinoma]], [[unclassified renal cell carcinoma]], [[clear cell renal cell carcinoma]], [[SMARCB1-deficient renal medullary carcinoma]] | | LMDDx = [[papillary renal cell carcinoma]], [[unclassified renal cell carcinoma]], [[clear cell renal cell carcinoma]], [[SMARCB1-deficient renal medullary carcinoma]], [[renal mucinous tubular and spindle cell carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = ALK +ve | | IHC = ALK +ve | ||
| Line 53: | Line 53: | ||
*[[Renal medullary carcinoma]]. | *[[Renal medullary carcinoma]]. | ||
*[[Clear cell renal cell carcinoma]].<ref name=pmid38039739/> | *[[Clear cell renal cell carcinoma]].<ref name=pmid38039739/> | ||
*[[Renal mucinous tubular and spindle cell carcinoma]].<ref>{{cite journal |vauthors=Kai K, Tobu S, Kido S, Mikami S, Takeuchi K, Dobashi A, Togashi Y, Noguchi M, Aishima S |title=ALK rearrangement-associated renal cell carcinoma morphologically mimicking mucinous tubular and spindle cell carcinoma: a case report |journal=Diagn Pathol |volume=17 |issue=1 |pages=52 |date=June 2022 |pmid=35718773 |pmc=9206751 |doi=10.1186/s13000-022-01238-z |url=}}</ref> | |||
==IHC== | ==IHC== | ||
Revision as of 22:49, 29 May 2025
| ALK translocation renal cell carcinoma | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | mixed morphology, +/-papillae, +/-myxoid change |
| LM DDx | papillary renal cell carcinoma, unclassified renal cell carcinoma, clear cell renal cell carcinoma, SMARCB1-deficient renal medullary carcinoma, renal mucinous tubular and spindle cell carcinoma |
| IHC | ALK +ve |
| Molecular | ALK rearranagement |
| Grossing notes | total nephrectomy for tumour grossing, partial nephrectomy grossing |
| Staging | kidney cancer staging |
| Site | kidney - see kidney tumours |
|
| |
| Prevalence | very rare |
| Treatment | may respond to ALK inhibitors |
ALK translocation renal cell carcinoma, also ALK-rearranged renal cell carcinoma and ALK-positive renal cell carcinoma, is a type of renal cell carcinoma recognized by the WHO.
General
- Extremely rare.
- May respond to ALK inhibitors such as alectinib[4] or crizotinib.[3]
Microscopic
Features:
- Mix of morphologies - including:
DDx:
- Papillary renal cell carcinoma - especially what used to be known as "type 2".[1]
- Unclassified renal cell carcinoma
- Renal medullary carcinoma.
- Clear cell renal cell carcinoma.[2]
- Renal mucinous tubular and spindle cell carcinoma.[6]
IHC
Features:[7]
- ALK +ve.
- PAX8 +ve.
- Vimentin +ve (diffuse).
- CK7 +ve (focal).
- SMARCB1 normal nuclear staining.[citation needed]
Molecular
- ALK rearrangement.
See also
References
- ↑ 1.0 1.1 1.2 Lee, C.; Park, JW.; Suh, JH.; Nam, KH.; Moon, KC. (Oct 2013). "ALK-Positive Renal Cell Carcinoma in a Large Series of Consecutively Resected Korean Renal Cell Carcinoma Patients.". Korean J Pathol 47 (5): 452-7. doi:10.4132/KoreanJPathol.2013.47.5.452. PMID 24255633.
- ↑ 2.0 2.1 Doğan K, Onder E (January 2024). "ALK-rearranged renal cell carcinoma (ALK-RCC): Evaluation of histomorphological and immunohistochemical features by analysis of 276 renal cell carcinoma cases in Turkey". Pathol Res Pract 253: 154951. doi:10.1016/j.prp.2023.154951. PMID 38039739.
- ↑ 3.0 3.1 Jeanneau, M.; Gregoire, V.; Desplechain, C.; Escande, F.; Tica, DP.; Aubert, S.; Leroy, X. (Nov 2016). "ALK rearrangements-associated renal cell carcinoma (RCC) with unique pathological features in an adult.". Pathol Res Pract 212 (11): 1064-1066. doi:10.1016/j.prp.2016.07.015. PMID 27554841.
- ↑ Pal, SK.; Bergerot, P.; Dizman, N.; Bergerot, C.; Adashek, J.; Madison, R.; Chung, JH.; Ali, SM. et al. (07 2018). "Responses to Alectinib in ALK-rearranged Papillary Renal Cell Carcinoma.". Eur Urol 74 (1): 124-128. doi:10.1016/j.eururo.2018.03.032. PMID 29685646.
- ↑ Kuroda, N.; Karashima, T.; Inoue, K.; Kasajima, A.; Ohe, C.; Kawakami, F.; Mikami, S.; Matsuura, K. et al. (Mar 2015). "Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects.". Pol J Pathol 66 (1): 3-8. PMID 26017874.
- ↑ "ALK rearrangement-associated renal cell carcinoma morphologically mimicking mucinous tubular and spindle cell carcinoma: a case report". Diagn Pathol 17 (1): 52. June 2022. doi:10.1186/s13000-022-01238-z. PMC 9206751. PMID 35718773. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206751/.
- ↑ Jeanneau, M.; Gregoire, V.; Desplechain, C.; Escande, F.; Tica, DP.; Aubert, S.; Leroy, X. (Nov 2016). "ALK rearrangements-associated renal cell carcinoma (RCC) with unique pathological features in an adult.". Pathol Res Pract 212 (11): 1064-1066. doi:10.1016/j.prp.2016.07.015. PMID 27554841.