Difference between revisions of "NKX3.1"
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[[Image:Urothelial carcinoma-like prostatic carcinoma - NKX3.1 -- intermed mag.jpg|thumb|right|NKX3.1 staining in prostate carcinoma.]] | |||
'''NKX3.1''' is a relatively new [[immunostain]] for [[prostate cancer]]. | '''NKX3.1''' is a relatively new [[immunostain]] for [[prostate cancer]]. | ||
==Positive== | ==Positive== | ||
*[[Prostatic carcinoma]].<ref>{{Cite journal | last1 = Gordetsky | first1 = J. | last2 = Epstein | first2 = JI. | title = Pseudopapillary features in prostatic adenocarcinoma mimicking urothelial carcinoma: a diagnostic pitfall. | journal = Am J Surg Pathol | volume = 38 | issue = 7 | pages = 941-5 | month = Jul | year = 2014 | doi = 10.1097/PAS.0000000000000178 | PMID = 24503758 }}</ref> | *[[Prostatic carcinoma]].<ref name=pmid24503758>{{Cite journal | last1 = Gordetsky | first1 = J. | last2 = Epstein | first2 = JI. | title = Pseudopapillary features in prostatic adenocarcinoma mimicking urothelial carcinoma: a diagnostic pitfall. | journal = Am J Surg Pathol | volume = 38 | issue = 7 | pages = 941-5 | month = Jul | year = 2014 | doi = 10.1097/PAS.0000000000000178 | PMID = 24503758 }}</ref> | ||
===Rarely positive=== | ===Rarely positive=== | ||
*[[Invasive ductal carcinoma of the breast]] ~2% of cases.<ref name=pmid24996432>{{Cite journal | last1 = Asch-Kendrick | first1 = RJ. | last2 = Samols | first2 = MA. | last3 = Lilo | first3 = MT. | last4 = Subhawong | first4 = AP. | last5 = Sharma | first5 = R. | last6 = Illei | first6 = PB. | last7 = Argani | first7 = P. | last8 = Cimino-Mathews | first8 = A. | title = NKX3.1 is expressed in ER-positive and AR-positive primary breast carcinomas. | journal = J Clin Pathol | volume = 67 | issue = 9 | pages = 768-71 | month = Sep | year = 2014 | doi = 10.1136/jclinpath-2014-202272 | PMID = 24996432 }}</ref> | *[[Invasive ductal carcinoma of the breast]] ~2% of cases.<ref name=pmid24996432>{{Cite journal | last1 = Asch-Kendrick | first1 = RJ. | last2 = Samols | first2 = MA. | last3 = Lilo | first3 = MT. | last4 = Subhawong | first4 = AP. | last5 = Sharma | first5 = R. | last6 = Illei | first6 = PB. | last7 = Argani | first7 = P. | last8 = Cimino-Mathews | first8 = A. | title = NKX3.1 is expressed in ER-positive and AR-positive primary breast carcinomas. | journal = J Clin Pathol | volume = 67 | issue = 9 | pages = 768-71 | month = Sep | year = 2014 | doi = 10.1136/jclinpath-2014-202272 | PMID = 24996432 }}</ref> | ||
*[[Invasive lobular carcinoma]] ~10% of cases.<ref name=pmid24996432/> | *[[Invasive lobular carcinoma]] ~10% of cases.<ref name=pmid24996432/> | ||
*Urothelial carcinoma with glandular differentiation.<ref>{{Cite journal | last1 = Abdo | first1 = M. | last2 = Hoyt | first2 = R. | last3 = Highfill | first3 = A. | last4 = Mettman | first4 = D. | title = Weak NKX3.1 expression in a urothelial carcinoma: A diagnostic pitfall | journal = Human Pathology Reports | volume = 27 | issue = | pages = | month = Mar | year = 2022 | doi = 10.1016/j.hpr.2022.300599 | PMID = | PMC = | url = https://www.sciencedirect.com/science/article/pii/S2772736X22000111 }}</ref> | |||
==See also== | ==See also== | ||
Latest revision as of 18:06, 9 April 2025
NKX3.1 is a relatively new immunostain for prostate cancer.
Positive
Rarely positive
- Invasive ductal carcinoma of the breast ~2% of cases.[2]
- Invasive lobular carcinoma ~10% of cases.[2]
- Urothelial carcinoma with glandular differentiation.[3]
See also
References
- ↑ Gordetsky, J.; Epstein, JI. (Jul 2014). "Pseudopapillary features in prostatic adenocarcinoma mimicking urothelial carcinoma: a diagnostic pitfall.". Am J Surg Pathol 38 (7): 941-5. doi:10.1097/PAS.0000000000000178. PMID 24503758.
- ↑ 2.0 2.1 Asch-Kendrick, RJ.; Samols, MA.; Lilo, MT.; Subhawong, AP.; Sharma, R.; Illei, PB.; Argani, P.; Cimino-Mathews, A. (Sep 2014). "NKX3.1 is expressed in ER-positive and AR-positive primary breast carcinomas.". J Clin Pathol 67 (9): 768-71. doi:10.1136/jclinpath-2014-202272. PMID 24996432.
- ↑ Abdo, M.; Hoyt, R.; Highfill, A.; Mettman, D. (Mar 2022). "Weak NKX3.1 expression in a urothelial carcinoma: A diagnostic pitfall". Human Pathology Reports 27. doi:10.1016/j.hpr.2022.300599. https://www.sciencedirect.com/science/article/pii/S2772736X22000111.