Difference between revisions of "Intestinal spirochetosis"
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| Line 13: | Line 13: | ||
| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = intestine - [[colon]] | | Site = intestine - [[colon]] | ||
| Line 24: | Line 24: | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = often normal | ||
| Prognosis = benign | | Prognosis = benign | ||
| Other = | | Other = | ||
| Line 43: | Line 43: | ||
Treatment:<ref name=pmid17914949>{{cite journal |author=Calderaro A, Bommezzadri S, Gorrini C, ''et al.'' |title=Infective colitis associated with human intestinal spirochetosis |journal=J. Gastroenterol. Hepatol. |volume=22 |issue=11 |pages=1772–9 |year=2007 |month=November |pmid=17914949 |doi=10.1111/j.1440-1746.2006.04606.x |url=}}</ref> | Treatment:<ref name=pmid17914949>{{cite journal |author=Calderaro A, Bommezzadri S, Gorrini C, ''et al.'' |title=Infective colitis associated with human intestinal spirochetosis |journal=J. Gastroenterol. Hepatol. |volume=22 |issue=11 |pages=1772–9 |year=2007 |month=November |pmid=17914949 |doi=10.1111/j.1440-1746.2006.04606.x |url=}}</ref> | ||
*Metronidazole. | *Metronidazole. | ||
==Gross== | |||
*Typically normal appearance. | |||
*Anatomical distribution in colon varies - may be absent in rectum.<ref>{{cite journal |authors=Walker MM, Talley NJ, Inganäs L, Engstrand L, Jones MP, Nyhlin H, Agréus L, Kjellstrom L, Öst Å, Andreasson A |title=Colonic spirochetosis is associated with colonic eosinophilia and irritable bowel syndrome in a general population in Sweden |journal=Hum Pathol |volume=46 |issue=2 |pages=277–83 |date=February 2015 |pmid=25540866 |doi=10.1016/j.humpath.2014.10.026 |url=}}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 19:27, 22 February 2024
| Intestinal spirochetosis | |
|---|---|
| Diagnosis in short | |
 Intestinal spirochetosis. H&E stain. | |
|
| |
| LM | hyperchromatic fuzz on luminal aspect of epithelial cells - at brush border; spirochetes |
| Stains | silver stains, e.g. Warthin-Starry stain |
| Site | intestine - colon |
|
| |
| Signs | watery diarrhea +/-blood per rectum |
| Symptoms | abdominal pain |
| Prevalence | uncommon |
| Endoscopy | often normal |
| Prognosis | benign |
| Clin. DDx | other causes of diarrhea |
| Treatment | antibiotics |
Intestinal spirochetosis, also known as intestinal spirochetes, in an uncommon intestinal infection.
It is usually in the colon; thus, also known as colonic spirochetes and colonic spirochetosis.
General
- Caused by spirochetes[1][2] - specifically Brachyspira piloicoli[3] (previously Serpulina pilosicoli[4]) and Brachyspira aalborgi.
- Very rare cause of diarrhea, associated with male homosexual behaviour.
Symptoms:[2]
- Watery diarrhea, abdominal pain, +/-blood per rectum.
Treatment:[5]
- Metronidazole.
Gross
- Typically normal appearance.
- Anatomical distribution in colon varies - may be absent in rectum.[6]
Microscopic
Features:
- Hyperchromatic fuzz on luminal aspect of epithelial cells; at brush border.
DDx:
- Normal colon.
- Infectious colitis without a distinctive morphology.
Images
Intestinal spirochetes - cropped - very high mag. (WC/Nephron)
Intestinal spirochetes - very high mag. (WC/Nephron)
Intestinal spirochetes - intermed. mag. (WC/Nephron)
www:
Special stains
- Silver stains highlight 'em (e.g. Warthin-Starry stain).
Images
Sign out
Rectum, Biopsy:
- Colonic-type mucosa with spirochetes, otherwise within normal limits.
Comment:
The presence of spirochetes was confirmed with a Warthin-Starry stain.
See also
References
- ↑ Amat Villegas I, Borobio Aguilar E, Beloqui Perez R, de Llano Varela P, Oquiñena Legaz S, Martínez-Peñuela Virseda JM (January 2004). "[Colonic spirochetes: an infrequent cause of adult diarrhea]" (in Spanish; Castilian). Gastroenterol Hepatol 27 (1): 21–3. PMID 14718105.
- ↑ 2.0 2.1 URL: http://www.jhasim.com/files/articlefiles/pdf/XASIM_Master_6_5_May_Vignette.pdf. Accessed on: 25 April 2011.
- ↑ Margawani, KR.; Robertson, ID.; Hampson, DJ. (Feb 2009). "Isolation of the anaerobic intestinal spirochaete Brachyspira pilosicoli from long-term residents and Indonesian visitors to Perth, Western Australia.". J Med Microbiol 58 (Pt 2): 248-52. doi:10.1099/jmm.0.004770-0. PMID 19141744. http://ukpmc.ac.uk/abstract/MED/19141744/abstract/MED/19141744?ukpmc_extredirect=http://dx.doi.org/10.1099/jmm.0.004770-0.
- ↑ URL: http://www.cdc.gov/ncidod/eid/vol12no05/05-1180.htm. Accessed on: 28 June 2011.
- ↑ Calderaro A, Bommezzadri S, Gorrini C, et al. (November 2007). "Infective colitis associated with human intestinal spirochetosis". J. Gastroenterol. Hepatol. 22 (11): 1772–9. doi:10.1111/j.1440-1746.2006.04606.x. PMID 17914949.
- ↑ Walker MM, Talley NJ, Inganäs L, Engstrand L, Jones MP, Nyhlin H, Agréus L, Kjellstrom L, Öst Å, Andreasson A (February 2015). "Colonic spirochetosis is associated with colonic eosinophilia and irritable bowel syndrome in a general population in Sweden". Hum Pathol 46 (2): 277–83. doi:10.1016/j.humpath.2014.10.026. PMID 25540866.
- ↑ Tsinganou, E.; Gebbers, JO. (Jan 2010). "Human intestinal spirochetosis--a review.". Ger Med Sci 8: Doc01. doi:10.3205/000090. PMID 20200654.